Abstract:
:Previous studies had reported that the CDKAL1 (cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1) rs10946398 C/A polymorphism associated with type 2 diabetes mellitus (T2DM) in various ethnic groups, however, inconsistent results have been obtained in studies of different populations.We performed a meta-analysis of 13 studies for rs10946398 of CDKAL1 on genetic susceptibility for T2DM.The results showed that CDKAL1 rs10946398 C/A polymorphism associated with T2DM under allelic (odds risk (OR): 1.17, 95% CI: 1.07-1.28, P = .0007), homozygous (OR: 1.39, 95% CI: 1.15-1.69, P = .0008), and dominant models (OR: 1.26, 95% CI: 1.09-1.46, P = .001).We found that rs10946398 C/A polymorphism was associated with T2DM, and this association was significantly in population of western country (Europe and United States) and Asian populations.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Liu X,Liang J,Geng H,Xu W,Teng F,Yang Mdoi
10.1097/MD.0000000000021383subject
Has Abstractpub_date
2020-07-24 00:00:00pages
e21383issue
30eissn
0025-7974issn
1536-5964pii
00005792-202007240-00096journal_volume
99pub_type
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