Association of Histone Methyltransferase G9a and Overall Survival After Liver Resection of Patients With Hepatocellular Carcinoma With a Median Observation of 40 Months.

Abstract:

:Approximately 50% of patients with hepatocellular carcinoma (HCC) reside in China. HCC is associated with very high mortality compared with other cancers. Although numerous factors influence the survival of patients with HCC who undergo liver resection, the role of the tumor biomarker histone methyltransferase (G9a) is unknown.We enrolled 350 patients with HCC who underwent liver resection and followed them for 40 months. Patients' clinicopathologic characteristics were acquired from medical records, and overall survival was determined using multiple methods. We conducted an immunohistochemical analysis of study G9a expression in HCC tissues. We used χ test to evaluate the significance of the relationships between G9a and other factors and Cox proportional hazards regression to estimate the hazard ratios and 95% confidence intervals.The levels of alpha-fetoprotein were significantly higher in patients with G9a-positive tumors. TNM stage, elevated alpha-fetoprotein level, and G9a overexpression were associated with worse outcomes.High expression of G9a was associated with worse outcomes, indicating that G9a may serve as a prognostic biomarker for patients with HCC who undergo surgical resection. Because of its role in cell proliferation, G9a represents a potential therapeutic target.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Bai K,Cao Y,Huang C,Chen J,Zhang X,Jiang Y

doi

10.1097/MD.0000000000002493

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

e2493

issue

2

eissn

0025-7974

issn

1536-5964

pii

00005792-201601120-00068

journal_volume

95

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Validation of the mortality in emergency department sepsis (MEDS) score in a Singaporean cohort.

    abstract::The emergency department (ED) serves as the first point of hospital contact for most septic patients. Early mortality risk stratification using a quick and accurate triage tool would have great value in guiding management. The mortality in emergency department sepsis (MEDS) score was developed to risk stratify patient...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016962

    authors: Pong JZ,Koh ZX,Samsudin MI,Fook-Chong S,Liu N,Ong MEH

    更新日期:2019-08-01 00:00:00

  • Transphyseal anterior cruciate ligament reconstruction in adolescents with substantial remaining growth causes temporary growth arrest resulting in subclinical leg-length discrepancy.

    abstract::The purpose of the present study was to investigate the characteristics of growth disturbances in patients with remaining growth after transphyseal anterior cruciate ligament (ACL) reconstruction who were confirmed to have no definite postoperative physeal abnormalities on magnetic resonance imaging (MRI).Forty adoles...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016081

    authors: Jeon JY,Lee J,Kang MS

    更新日期:2019-06-01 00:00:00

  • Anticancer effect of Saussurea lappa extract via dual control of apoptosis and autophagy in prostate cancer cells.

    abstract::To demonstrate the mechanisms of the curative effect of Saussurea lappa ethanol extract (SLE) against prostate cancer, we evaluated the effect of SLE on the induction of apoptosis and autophagy and investigated whether SLE-induced autophagy exerts a pro-survival or pro-apoptotic effect in lymph node carcinoma of the p...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007606

    authors: Tian X,Song HS,Cho YM,Park B,Song YJ,Jang S,Kang SC

    更新日期:2017-07-01 00:00:00

  • rs1495741 as a tag single nucleotide polymorphism of N-acetyltransferase 2 acetylator phenotype associates bladder cancer risk and interacts with smoking: A systematic review and meta-analysis.

    abstract::Rs1495741 has been identified to infer N-acetyltransferase 2 (NAT2) acetylator phenotype, and to decrease the risk of bladder cancer. However, a number of studies conducted in various regions showed controversial results. To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the ...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000004417

    authors: Ma C,Gu L,Yang M,Zhang Z,Zeng S,Song R,Xu C,Sun Y

    更新日期:2016-08-01 00:00:00

  • Oxycodone versus fentanyl for intravenous patient-controlled analgesia after laparoscopic supracervical hysterectomy: A prospective, randomized, double-blind study.

    abstract:BACKGROUND:Oxycodone, a semisynthetic thebaine derivative opioid, is widely used for the relief of moderate to severe pain. The aim of this study was to compare the efficacy and side effects of oxycodone and fentanyl in the management of postoperative pain by intravenous patient-controlled analgesia (IV-PCA) in patient...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000006286

    authors: Kim NS,Lee JS,Park SY,Ryu A,Chun HR,Chung HS,Kang KS,Chung JH,Jung KT,Mun ST

    更新日期:2017-03-01 00:00:00

  • Increased risk of herpes zoster in patients with peptic ulcers: A longitudinal follow-up study using a national sample cohort.

    abstract::The purpose of this study was to investigate the association of herpes zoster infection with peptic ulcer disease in a Korean population.The Korean National Health Insurance Service selects samples directly from the entire Korean population database, and 1,125,691 participants with 114,369,638 medical claim codes were...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019318

    authors: Jin YJ,Park B,Park IS,Choi HG

    更新日期:2020-02-01 00:00:00

  • A novel application of drug-eluting transarterial chemoembolization in treating non-liver cancers.

    abstract::This case series aimed to preliminarily evaluate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) in patients with lung, renal, gastric, and other non-liver cancers.Twenty-four patients who underwent DEB-TACE or DEB-TACE combined with other therapies were reviewed in this case s...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020878

    authors: Li Z,Ji K,Bai L,Wang C,Hu Y,Shi Y,Zhan P,Song L,Li X,Duan X,Han X

    更新日期:2020-07-31 00:00:00

  • Efficacy of erlotinib and celecoxib for patients with advanced non-small cell lung cancer: A retrospective study.

    abstract::This study evaluated the efficacy and toxicity of erlotinib and celecoxib (EC) for treating Chinese patients with advanced non-small cell lung cancer (ANSCLC) and epidermal growth factor receptor (EGFR) wild type.Totally, 75 subjects with ANSCLC and EGFR wild type were included. They all underwent EC treatment. The ou...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014785

    authors: Jin YH,Li WH,Bai Y,Ni L

    更新日期:2019-03-01 00:00:00

  • Surgical management of tailgut cysts: A rare case report.

    abstract:RATIONALE:Tailgut cysts are a type of very rare congenital polycystic lesions that are always located posterior to the rectum and anterior to the sacrum. The symptoms of tailgut cysts are nonspecific and misleading. Therefore, a full understanding of the characteristics of tailgut cysts is important for their diagnosis...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014448

    authors: Li J,Song X,Shi J,Zhang K,Liu T

    更新日期:2019-02-01 00:00:00

  • Management of iatrogenic renal arteriovenous fistula and renal arterial pseudoaneurysm by transarterial embolization: A single center analysis and outcomes.

    abstract::The purpose of this study was to evaluate the efficacy and safety of transarterial embolization (TAE) for iatrogenic renal arterial pseudoaneurysm and arteriovenous fistula at our center.Our retrospective analysis included 27 patients who received TAE for iatrogenic renal arterial pseudoaneurysm and arteriovenous fist...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008187

    authors: Guo H,Wang C,Yang M,Tong X,Wang J,Guan H,Song L,Zou Y

    更新日期:2017-10-01 00:00:00

  • The relevance of MTHFR C677T, A1298C, and MTRR A66G polymorphisms with response to male infertility in Asians: A meta-analysis.

    abstract::Although published studies have reported the association between MTHFR C677T (rs 1801133), A1298C (rs 1801131), and MTRR A66G (rs1801394) polymorphisms and male infertility in Asian populations, the results are conflicting. In order to accurately evaluate the relevance, a meta-analysis was performed.We searched for po...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000014283

    authors: Shi TL,Wu Y,Li Y,Chen ZF,Ma YN,Zhang ZT,Zhang YH,Zhang L

    更新日期:2019-02-01 00:00:00

  • Disabling tremor induced by long-term use of sodium valproate and lamotrigine: Case report.

    abstract:RATIONALE:Sodium valproate (VPA) and lamotrigine (LTG) are widely used antiepileptic drugs, disabling postural, and action tremors after using LTG with VPA were reported in 1993. However, in this study, we describe a patient in whom disabling resting-type tremor induced by 2-year use of VPA and LTG. PATIENT CONCERNS:A...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008711

    authors: He ZF,Chen J,Zhou CN,Rao Z,Wang XH

    更新日期:2017-11-01 00:00:00

  • The first case report of a large deletion of the BRCA1 gene in Croatia: A case report.

    abstract:RATIONALE:Breast cancer is one of the most common cancers in women, and it is the leading cause of cancer related deaths in Croatia. BRCA1 and BRCA2 gene mutations are the most common cause of hereditary breast cancer. PATIENT CONCERNS:In this report we describe a Croatian patient with no apparent family history of ca...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008667

    authors: Musani V,Sušac I,Ozretić P,Eljuga D,Levanat S

    更新日期:2017-12-01 00:00:00

  • A case report: identification of a novel exon 1 deletion mutation in the GNE gene in a Chinese patient with GNE myopathy.

    abstract:RATIONALE:GNE myopathy is caused by mutations in the UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase(GNE) gene and is clinically characterized by progressive weakness and atrophy of the lower-limb muscles with quadriceps sparing. Nearly all GNE mutations that have been reported thus far in various ethnic...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022663

    authors: Miao J,Wei XJ,Wang X,Yin X,Yu XF

    更新日期:2020-10-09 00:00:00

  • Emergency department companions of stroke patients: implications on quality of care.

    abstract::Acute care of stroke victims largely relies on the rapid identification and timely clinical and radiological assessment. We evaluated the effect of the number of patient companions on the efficiency of the diagnostic process in the emergency department (ED).Consecutive stroke patients admitted to the ED between August...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000520

    authors: Ashkenazi L,Toledano R,Novack V,EIluz E,Abu-Salamae I,Ifergane G

    更新日期:2015-03-01 00:00:00

  • The Correlations Between MRI Perfusion, Diffusion Parameters, and 18F-FDG PET Metabolic Parameters in Primary Head-and-Neck Cancer: A Cross-Sectional Analysis in Single Institute.

    abstract::This study aimed to investigate the relationships among parameters from dynamic contrast-enhanced (DCE) MRI, diffusion-weighted MRI (DWI), and F-fluorodeoxyglucose (F-FDG) PET in patients with primary head-and-neck squamous cell carcinoma (HNSCC).A total of 34 patients with primary HNSCC underwent DCE-MRI, DWI, and F-...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002141

    authors: Han M,Kim SY,Lee SJ,Choi JW

    更新日期:2015-11-01 00:00:00

  • Higher hypertension prevalence, lower incidence, and aggressive treatment with decreasing mortality, cardiovascular, and cerebrovascular incidence in Taiwan from 2005 to 2010: A 2 population-based cohorts study.

    abstract::Hypertension continues to be an important public health concern because of its associated morbidity, mortality, and economic impact on society. The aims of this study are to compare the secular changes in age-stratified hypertension prevalence, incidence, co-morbidity, and 3 years of cardiovascular outcome in Taiwan i...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022437

    authors: Liao CT,Wu PC,Shih JC,Cheng TJ,Wu WS

    更新日期:2020-09-25 00:00:00

  • The effectiveness and safety of extracorporeal shock wave lithotripsy for the management of kidney stones: A protocol of systematic review and meta-analysis.

    abstract:BACKGROUND:Extracorporeal shockwave lithotripsy (ESWL) has gained worldwide popularity as one of the most commonly used minimally invasive management of urinary tract stones. The objective of this study was to evaluate the efficacy and safety of ESWL for patients with kidney stones (KS). MATERIALS AND METHODS:This pro...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021910

    authors: Cao L,Wang YQ,Yu T,Sun Y,He J,Zhong Y,Li X,Sun X

    更新日期:2020-09-18 00:00:00

  • Replacement of dexmedetomidine loading with midazolam for sedation in elderly patients with spinal anesthesia.

    abstract:BACKGROUND:Dexmedetomidine is an effective sedative during spinal anesthesia. However, it requires a loading dose, which can result in transient hypertension, hypotension, bradycardia, and/or sinus arrest. In addition, the time required to reach an appropriate depth of sedation may cause anxiety to the patients. Theref...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012565

    authors: Park SW,Choi JH,Kim HT,Cho YH

    更新日期:2018-09-01 00:00:00

  • Efficacy and safety of traditional Chinese medicine for erosive oral lichen planus: A protocol for systematic review and meta analysis.

    abstract:BACKGROUND:Oral lichen planus (OLP) is a common disease among oral mucous membrane diseases. Erosive oral lichen planus (EOLP) is a type of OLP, it has a potential tendency of cancerization. There have been some randomized controlled trials (RCTs) using Traditional Chinese Medicine (TCM) to treat EOLP. No systematic re...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000023375

    authors: You Y,Huang X,Chen Y,You Y

    更新日期:2020-11-25 00:00:00

  • Applicability of ultrasonography for detection of marginal sinus placenta previa.

    abstract:ABSTRACT:This study aimed to examine whether marginal sinus placenta previa, defined as when the marginal sinus just reaches the internal cervical os and placental parenchyma might be >2 cm from the internal cervical os, can be diagnosed using ultrasonography (US). We identified the placenta previa cases that underwent...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000024253

    authors: Ishibashi H,Miyamoto M,Shinmoto H,Soga S,Iwahashi H,Kakimoto S,Matsuura H,Sakamoto T,Hada T,Suzuki R,Takano M

    更新日期:2021-01-08 00:00:00

  • What Do Stroke Patients Look for in Game-Based Rehabilitation: A Survey Study.

    abstract::Stroke is one of the most common causes of physical disability, and early, intensive, and repetitive rehabilitation exercises are crucial to the recovery of stroke survivors. Unfortunately, research shows that only one third of stroke patients actually perform recommended exercises at home, because of the repetitive a...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003032

    authors: Hung YX,Huang PC,Chen KT,Chu WC

    更新日期:2016-03-01 00:00:00

  • Hemocoagulase reduces postoperative bleeding and blood transfusion in cardiac surgical patients: A PRISMA-compliant systematic review and meta-analysis.

    abstract:BACKGROUND:Hemocoagulase is isolated and purified from snake venoms. Hemocoagulase agents have been widely used in the prevention and treatment of surgical bleeding. A systematic review was performed to evaluate the effects of hemocoagulase on postoperative bleeding and transfusion in patients who underwent cardiac sur...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000018534

    authors: Yao YT,Yuan X,Fang NX

    更新日期:2019-12-01 00:00:00

  • Prognostic value of pretreatment lymphocyte-to-monocyte ratio in patients with urologic tumors: A PRISMA-compliant meta-analysis.

    abstract:BACKGROUND:The prognostic value of pretreatment lymphocyte to monocyte ratio (LMR) in patients with urologic tumors remains controversial. Therefore, we herein conducted a meta-analysis to systematically assess the prognostic value of LMR in patients with urologic tumors. METHODS:We comprehensively searched PubMed, EM...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000014091

    authors: Li J,Cheng Y,Ji Z

    更新日期:2019-01-01 00:00:00

  • A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis.

    abstract::To investigate the pathogenesis of somatic solid cancer-related cerebral venous sinus thrombosis (CVST).A total of 174 patients with CVST were recruited from the hospital between January 2006 and December 2017 and divided into two groups: (1) somatic cancer-related CVST group, defined as active somatic solid cancer pa...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015134

    authors: Xian Z,Chen Y,Chen L,Lu Q,Huang G,Qin Q,Zeng J,Liang Z

    更新日期:2019-05-01 00:00:00

  • Efficacy of pirfenidone for the treatment of pulmonary fibrosis: An updated systematic review protocol of randomized controlled trial.

    abstract:BACKGROUND:This study will systematically assess the efficacy and safety of pirfenidone for the treatment of patients with pulmonary fibrosis (PF). METHODS:We will search potential records from following literature sources from their inceptions to the present without language, and publication status limitations: Cochr...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000015407

    authors: Li SM,Lin Y,Liang SS

    更新日期:2019-04-01 00:00:00

  • Probiotics, prebiotics, and synbiotics for the treatment of asthma: Protocol for a systematic review.

    abstract:BACKGROUND:Asthma is a common chronic disease with heavy burden. The number of asthma patients may continue to grow in the next 10 years. Existing conventional treatments have problems in which a small number of patients do not respond, often accompanied by side effects, or are too expensive. Probiotics, prebiotics, an...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017840

    authors: Huang L,Guo J,Li W,Jiang M,Wang F,Kang J,Liu T,Gu X

    更新日期:2019-11-01 00:00:00

  • Three primary synchronous malignancies of the uterus, cervix, and fallopian tube: A case report.

    abstract:RATIONALE:Multiple primary malignancies can occur in the same organ or in multiple organs or systems. Likewise, they can occur simultaneously or successively. Based on the timing of the diagnosis, they are classified as multiple synchronous (i.e., concurrent) or metachronous (i.e., successive) primary malignancies. The...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011107

    authors: Song L,Li Q,Yang K,Yin R,Wang D

    更新日期:2018-06-01 00:00:00

  • Are spiritual interventions beneficial to patients with cancer?: A meta-analysis of randomized controlled trials following PRISMA.

    abstract:BACKGROUND:In addition to the physical burden, the quality of life and survival in patients with cancer may also be reduced because of psychological distress, such as spiritual crisis, anxiety, and depression. Many studies have verified that spirituality could reduce anxiety and depression and improve quality of life a...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000011948

    authors: Xing L,Guo X,Bai L,Qian J,Chen J

    更新日期:2018-08-01 00:00:00

  • Costs of Physician-Hospital Integration.

    abstract::Given that the enactment of the Patient Protection and Affordable Care Act of 2010 is expected to generate forces toward physician-hospital integration, this study examined an understudied, albeit important, area of costs incurred in physician-hospital integration. Such costs were analyzed through 24 semi-structured i...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001762

    authors: Cho NE

    更新日期:2015-10-01 00:00:00