Efficacy of erlotinib and celecoxib for patients with advanced non-small cell lung cancer: A retrospective study.

Abstract:

:This study evaluated the efficacy and toxicity of erlotinib and celecoxib (EC) for treating Chinese patients with advanced non-small cell lung cancer (ANSCLC) and epidermal growth factor receptor (EGFR) wild type.Totally, 75 subjects with ANSCLC and EGFR wild type were included. They all underwent EC treatment. The outcome measurements consisted of progression-free survival (PFS), overall survival (OS), complete response (CR), partial response (PR), stable disease (SD), progress disease (PD), and disease control rate (DCR). Additionally, adverse events were also documented.Two-year CR, PR, SD, PD, and DCR were 4.0%, 6.7%, 42.6%, 46.7%, and 53.3% respectively. The median PFS was 3.4 months, the median OS was 10.0 months. Additionally, acceptable toxicities were recorded in this study.The results showed that EC may be efficacious for patients with ANSCLC and EGFR wild type only, and acceptable toxicity among the Chinese Han population.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Jin YH,Li WH,Bai Y,Ni L

doi

10.1097/MD.0000000000014785

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

e14785

issue

10

eissn

0025-7974

issn

1536-5964

pii

00005792-201903080-00059

journal_volume

98

pub_type

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