Abstract:
:This study evaluated the efficacy and toxicity of erlotinib and celecoxib (EC) for treating Chinese patients with advanced non-small cell lung cancer (ANSCLC) and epidermal growth factor receptor (EGFR) wild type.Totally, 75 subjects with ANSCLC and EGFR wild type were included. They all underwent EC treatment. The outcome measurements consisted of progression-free survival (PFS), overall survival (OS), complete response (CR), partial response (PR), stable disease (SD), progress disease (PD), and disease control rate (DCR). Additionally, adverse events were also documented.Two-year CR, PR, SD, PD, and DCR were 4.0%, 6.7%, 42.6%, 46.7%, and 53.3% respectively. The median PFS was 3.4 months, the median OS was 10.0 months. Additionally, acceptable toxicities were recorded in this study.The results showed that EC may be efficacious for patients with ANSCLC and EGFR wild type only, and acceptable toxicity among the Chinese Han population.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Jin YH,Li WH,Bai Y,Ni Ldoi
10.1097/MD.0000000000014785subject
Has Abstractpub_date
2019-03-01 00:00:00pages
e14785issue
10eissn
0025-7974issn
1536-5964pii
00005792-201903080-00059journal_volume
98pub_type
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