Prognostic comparison between mucinous and nonmucinous adenocarcinoma in colorectal cancer.

Abstract:

:Mucinous adenocarcinoma (MAC) is a histological subtype of colorectal cancer. The oncologic behavior of MAC differs from nonmucinous adenocarcinoma (non-MAC). Our aim in this study was to characterize patients with colorectal MAC through evaluation of a large, institutional-based cohort with long-term follow-up. A total of 6475 patients with stages I to III colorectal cancer who underwent radical surgery were enrolled from January 2000 to December 2010. Prognostic comparison between MAC (n = 274, 4.2%) and non-MAC was performed. The median follow-up period was 48.0 months. Patients with MAC were younger than those without MAC (P = 0.012) and had larger tumor size (P < 0.001), higher preoperative carcinoembryonic antigen (P < 0.001), higher pathologic T stage (P < 0.001), more right-sided colon cancer (49.3%, P < 0.001), and more frequent high-frequency microsatellite instability (10.2%, P < 0.001). Five-year disease-free survival (DFS) was 76.5% in the MAC group and 83.2% in the non-MAC group (P = 0.008), and 5-year overall survival was 81.4% versus 87.4%, respectively (P = 0.005). Mucinous histology (MAC vs non-MAC) in the entire cohort was not an independent prognostic factor of DFS but had a statistical tendency (P = 0.071). In subgroup analysis of colon cancer without rectal cancer, mucinous histology was an independent prognostic factor (P = 0.026). MAC was found at more advanced stage, located mainly at the right side and was an independent factor of survival in colon cancer. Because of the unique biological behavior of MAC, patients with MAC require special consideration during follow-up.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Park JS,Huh JW,Park YA,Cho YB,Yun SH,Kim HC,Lee WY,Chun HK

doi

10.1097/MD.0000000000000658

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

e658

issue

15

eissn

0025-7974

issn

1536-5964

pii

00005792-201504030-00008

journal_volume

94

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Complete laparoscopic cholecystectomy for a duplicated gallbladder: A case report.

    abstract:INTRODUCTION:Duplication of the gallbladder (GB) is a rare congenital abnormality occurring in 1 in 4000 to 5000 births. Three types have been reported: type I (split primordial GB), type II (2 separate GBs with their own cystic ducts), and type III (triple GBs drained by 1 to 3 separate cystic ducts). Patients with a ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018363

    authors: Zhou DK,Huang Y,Kong Y,Ye Z,Ying LX,Wang WL

    更新日期:2020-01-01 00:00:00

  • Coreceptor usage of Chinese HIV-1 and impact of X4/DM transmission clusters among recently infected men who have sex with men.

    abstract::To characterize the current frequency of HIV-1 coreceptor usage in China and assess the candidacy of CCR5 antagonists for treatment of HIV infections. In addition, we aimed to evaluate the potential of X4/DM virus transmission in recently infected men who have sex with men (MSM) individuals.Viral tropism testing was p...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005017

    authors: Li X,Zhu K,Li W,Fang K,Musa TH,Song Y,Du G,Gao R,Guo Y,Yan W,Xuan Y,Zhong P,Wei P

    更新日期:2016-09-01 00:00:00

  • Step Counter Use and Sedentary Time in Adults: A Meta-Analysis.

    abstract::Although step counters are increasingly being used in walking programmes to promote sedentary behavior changes in adults, their effectiveness remains unknown. The aim of this meta-analysis of randomized controlled trials (RCTs) was to assess the effectiveness of step counter use in reducing sedentary time among adults...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000001412

    authors: Qiu S,Cai X,Ju C,Sun Z,Yin H,Zügel M,Otto S,Steinacker JM,Schumann U

    更新日期:2015-09-01 00:00:00

  • Salvage Chemotherapy for Patients With Recurrent or Persistent Ovarian Clear Cell Carcinoma: A Retrospective Study of 164 Cases.

    abstract::The purpose of this study was to evaluate the effects of salvage chemotherapy on recurrent or persistent ovarian clear cell carcinoma (CCC) with the goal of identifying a more rational treatment regimen for this lethal disease.The medical records of patients with CCC were retrospectively reviewed to select patients th...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001121

    authors: Bai H,Sha G,Cao D,Yang J,Chen J,Wang Y,Lang J,Shen K,Zhang Z

    更新日期:2015-07-01 00:00:00

  • Keratoacanthoma and Keratoacanthoma-Like Squamous Cell Carcinoma: Similar Morphology but Different Pathogenesis.

    abstract::Differential diagnosis between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is difficult due to their similarities. The mechanisms that drive their distinct biological behavior are poorly understood. To investigate whether the assessment of microvessel density (MVD) could be helpful in KA and SCC differentia...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000934

    authors: Watanabe IC,Magalhães RF,de Moraes AM,Stelini RF,Cintra GF,Metze K,Cintra ML

    更新日期:2015-06-01 00:00:00

  • Effects of different interventions on animal models of ischemic stroke: Protocol for an overview and a network meta-analysis.

    abstract:BACKGROUND:Ischemic stroke often leads to lifelong disability or death in stroke patients. It is one of the most common causes of death and disability worldwide, so it is a global health problem. The objective of this protocol is to provide the methods for using overview and network meta-analysis to identify the more e...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000015384

    authors: Zhang Y,Yu HJ,Shi SZ,Wang JC

    更新日期:2019-04-01 00:00:00

  • Anthropometric and Quality-of-Life Parameters in Acute Intermittent Porphyria Patients.

    abstract::The porphyrias are a group of rare metabolic disorders. The incidence and prevalence are low because the acute intermittent porphyria (AIP) is rare. Our aim was to assess the use of anthropometric and quality-of-life parameters in porphyric patients in order to identify predictor factors that might help in characteriz...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001023

    authors: Jiménez-Monreal AM,Murcia M,Gómez-Murcia V,Bibiloni MDM,Pons A,Tur JA,Martínez-Tomé M

    更新日期:2015-07-01 00:00:00

  • Cardiac septic pulmonary embolism: A retrospective analysis of 20 cases in a Chinese population.

    abstract::Based on the source of the embolus, septic pulmonary embolism (SPE) can be classified as cardiac, peripheral endogenous, or exogenous. Cardiac SPEs are the most common.We conducted a retrospective analysis of 20 patients with cardiac SPE hospitalized between 1991 and 2013 at a Chinese tertiary referral hospital.The st...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003846

    authors: Song XY,Li S,Cao J,Xu K,Huang H,Xu ZJ

    更新日期:2016-06-01 00:00:00

  • Point prevalence and epidemiological characteristics of chronic cough in the general adult population: The Korean National Health and Nutrition Examination Survey 2010-2012.

    abstract::Cough is frequently self-limiting, but may persist longer in certain individuals. Most of previous studies on the epidemiology of chronic cough have only measured period prevalence, and thus have afforded limited information on the burden and natural course. We aimed to investigate the epidemiology of chronic cough by...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006486

    authors: Kang MG,Song WJ,Kim HJ,Won HK,Sohn KH,Kang SY,Jo EJ,Kim MH,Kim SH,Kim SH,Park HW,Chang YS,Lee BJ,Morice AH,Cho SH

    更新日期:2017-03-01 00:00:00

  • Electro-acupuncture attenuates inflammatory responses and intraabdominal pressure in septic patients: A randomized controlled trial.

    abstract:BACKGROUND:A pathological increase in intraabdominal pressure (IAP) and inflammatory responses have negative effects on splanchnic, respiratory, cardiovascular, renal, and neurological function in septic patients with intestinal dysfunction. Electro-acupuncture (EA) has been evidenced to have a bidirectional neuron-end...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000010555

    authors: Meng JB,Jiao YN,Xu XJ,Lai ZZ,Zhang G,Ji CL,Hu MH

    更新日期:2018-04-01 00:00:00

  • Spinal epidural hematoma occurring at a distance from the transforaminal epidural injection site: A case report.

    abstract:RATIONALE:Transforaminal epidural steroid injection (TFESI) is a conservative method to treat back pain due to radiculopathy. However, epidural hematoma can occur after the procedure by various mechanisms, which can cause serious complications. PATIENT CONCERNS:An 82-year-old man with spinal stenosis was treated with ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016654

    authors: Kim SI,Lee DH,Kim SH,Cho YH

    更新日期:2019-07-01 00:00:00

  • Age, sex, and the association of chronic kidney disease with all-cause mortality in Buddhist priests: An analysis of the standardized mortality ratio from the Korean Buddhist priests cohort.

    abstract::Buddhist priests lead a unique lifestyle, practicing asceticism, with a vegetarian diet. Such behavior may have an impact on clinical outcomes. Hence, we explored the mortality among Korean Buddhist priests as compared with the general population.This study is a single-center, retrospective study. Among the 3867 Buddh...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013099

    authors: Kim HJ,Kim Y,Kim S,Chin HJ,Lee H,Lee JP,Kim DK,Oh KH,Joo KW,Kim YS,Nah DY,Shin SJ,Kim KS,Park JY,Yoo KD

    更新日期:2018-11-01 00:00:00

  • Treatment of lateral epicondylitis with acupuncture and glucocorticoid: A retrospective cohort study.

    abstract::Lateral epicondylitis (LE) is a common musculoskeletal disorder for which an effective treatment strategy remains unknown. The goal of this study is to examine whether acupuncture is more effective than injection of glucocorticoid in adults with LE.Adults with LE received either acupuncture or injection of glucocortic...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019227

    authors: Peng Z,Zhang M,Li Y,Feng Z

    更新日期:2020-02-01 00:00:00

  • The Association of Ursodeoxycholic Acid Use With Colorectal Cancer Risk: A Nationwide Cohort Study.

    abstract::Data from preclinical studies suggest that ursodeoxycholic acid (UDCA) has a chemopreventive effect on colorectal cancer (CRC) development, but no large observational study has examined this possibility. The aim of this study was to investigate the association of UDCA use with CRC risk in a nationwide population-based...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002980

    authors: Huang WK,Hsu HC,Liu JR,Yang TS,Chen JS,Chang JW,Lin YC,Yu KH,Kuo CF,See LC

    更新日期:2016-03-01 00:00:00

  • A case report of a child with sepsis induced multiorgan failure and massive complement consumption treated with a short course of Eculizumab: A case of crosstalk between coagulation and complement?

    abstract:RATIONALE:This article describes a child with a life-threatening multiorgan failure with disseminated intravascular coagulation (DIC) and massive complement consumption. To our knowledge this therapeutic approach was for the first time effectively applied in a pediatric patient. PATIENT CONCERNS:A 14-month-old boy was...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014105

    authors: Galic S,Csuka D,Prohászka Z,Turudic D,Dzepina P,Milosevic D

    更新日期:2019-01-01 00:00:00

  • Hyperthermic intraperitoneal chemotherapy combined with systemic chemotherapy for gastric cancer peritoneal carcinomatosis: A protocol for systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:The prognosis of gastric cancer peritoneal carcinomatosis (GCPC) remains poor despite recent advances in systemic chemotherapy (SC) with an average survival less than 6 months. Current evidence supporting the utility of hyperthermic intraperitoneal chemotherapy (HIPEC) combined with SC for GCPC is limited. W...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020973

    authors: Lu Y,Jin Z,Zheng S,Bai Y,Sun Y

    更新日期:2020-07-02 00:00:00

  • Intensive Periodontal Treatment Reduces Risk of Infection-Related Hospitalization in Hemodialysis Population: A Nationwide Population-Based Cohort Study.

    abstract::Periodontal disease (PD) is prevalent and correlated with malnutrition and inflammation in patients on hemodialysis (HD). Periodontal therapy improves systemic inflammatory and nutritional markers in HD population. The relationship between intensive PD therapy and clinical infectious outcomes in patients on HD remains...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001436

    authors: Huang ST,Lin CL,Yu TM,Wu MJ,Kao CH

    更新日期:2015-08-01 00:00:00

  • Surgical treatment of acute calculous cholecystitis complicated with hepatic dysfunction.

    abstract::To evaluate the timing, feasibility, and necessity of early laparoscopic cholecystectomy (LC) in the management of patients with acute calculous cholecystitis complicated with hepatic dysfunction.The clinical data of 60 patients with acute calculous cholecystitis complicated with hepatic dysfunction treated from Janua...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020239

    authors: Tian Y,Suo X

    更新日期:2020-06-12 00:00:00

  • Management and clinical outcomes of periprosthetic fractures after total knee arthroplasty with a stem extension.

    abstract::There is little information about the management and clinical outcomes of the periprosthetic fracture after total knee arthroplasty (TKA) with a stem extension. The purposes of this study were to demonstrate management of the periprosthetic fractures after TKA with a stem extension, to report treatment outcomes, and t...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016088

    authors: Shin JH,Chang MJ,Kang SB,Chang CB,Kim DH,Lee SA,Mok SJ

    更新日期:2019-06-01 00:00:00

  • The association between rs12807809 polymorphism in neurogranin gene and risk of schizophrenia: A meta-analysis.

    abstract:BACKGROUND:The correlation between single nucleotide polymorphism (SNP) rs12807809 in Neurogranin (NRGN) gene and Schizophrenia (SCZ) was investigated by several studies, whereas the results were conflicting. Thus, we performed the present meta-analysis to combine and analyze the available studies in order to provide a...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000018518

    authors: Jin L,An Z,Xu B,Mu D,Fu S,Hu H,Shi Y,Luo X,Yi Q

    更新日期:2019-12-01 00:00:00

  • Promising significance of the association of miR-204-5p expression with clinicopathological features of hepatocellular carcinoma.

    abstract::Decreased level of miR-204-5p has been documented in various malignancies. However, the expression and clinical significance of miR-204-5p in hepatocellular carcinoma has not been investigated. The aim of this study is to examine the relationship between miR-204-5p expression and clinicopathological features in hepato...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000007545

    authors: Luo YH,Tang W,Zhang X,Tan Z,Guo WL,Zhao N,Pang SM,Dang YW,Rong MH,Cao J

    更新日期:2017-07-01 00:00:00

  • Gender- and age-dependent tongue features in a community-based population.

    abstract::This study, an important groundwork for clinical tongue diagnosis and future traditional Chinese medicine (TCM) research, tested the hypothesis that some tongue features vary significantly between different gender and age groups by utilizing an automatic tongue diagnosis system (ATDS).A cross-sectional study of 1487 p...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018350

    authors: Hsu PC,Wu HK,Huang YC,Chang HH,Chen YP,Chiang JY,Lo LC

    更新日期:2019-12-01 00:00:00

  • Effect of phosphoric acid concentration used for etching on the microtensile bond strength to fluorotic teeth.

    abstract::To evaluate the effects of different etching concentrations of phosphoric acid on the microtensile bond strength of Adper Single Bond 2 to fluorotic teeth.Deidentified extracted teeth were collected, including 30 sound teeth, 30 teeth with mild fluorosis, 30 teeth with moderate fluorosis, and 30 teeth with severe fluo...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012093

    authors: Gu M,Lv L,He X,Li W,Guo L

    更新日期:2018-08-01 00:00:00

  • Erratum: A simple blind placement of the left-sided double-lumen tubes: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000005376.]. ...

    journal_title:Medicine

    pub_type: 已发布勘误

    doi:10.1097/MD.0000000000006196

    authors:

    更新日期:2017-02-17 00:00:00

  • Folic Acid Intake and Neural Tube Defects: Two Egyptian Centers Experience.

    abstract::Neural tube defects (NTDs) are a group of congenital malformations with worldwide distribution and complex etiopathogenesis. Folic acid plays a pivotal role in their prevention. We aimed to identify the protective effect of folic acid intake against NTDs and its dependence on different socioeconomic and environmental ...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MD.0000000000001395

    authors: El-Shabrawi MH,Kamal NM,Elhusseini MA,Hussein L,Abdallah EAA,Ali YZA,Azab AA,Salama MA,Kassab M,Krawinkel M

    更新日期:2015-09-01 00:00:00

  • The Lemierre syndrome: suppurative thrombophlebitis of the internal jugular vein secondary to oropharyngeal infection.

    abstract::We present 2 cases of the Lemierre syndrome (also called postanginal septicemia), along with 36 other cases from a review of recent literature. A review of the literature during the preantibiotic era is also included. This disease is caused by an acute oropharyngeal infection with secondary thrombophlebitis of the int...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Sinave CP,Hardy GJ,Fardy PW

    更新日期:1989-03-01 00:00:00

  • Prospective comparison of preference and efficacy of adalimumab and infliximab for treating ulcerative colitis naive to antitumor necrosis factor therapy.

    abstract::There have been few reports on 2 tumor necrosis factor alpha inhibitors, infliximab and adalimumab, with respect to patient preference and efficacy in ulcerative colitis (UC).We used questionnaires to evaluate the preference and reasons for drug choice between infliximab and adalimumab in UC patients naive to antitumo...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007800

    authors: Mizoshita T,Katano T,Tanida S,Hirano A,Miyaki T,Ozeki K,Suzuki Y,Sugimura N,Kataoka H,Joh T

    更新日期:2017-08-01 00:00:00

  • Acupuncture for anxiety: A protocol for a systematic review of controlled trials.

    abstract:BACKGROUND:Acupuncture has been widely, used in Asian countries since the Yuan Dynasty in China. Moreover, acupuncture has been reported to exhibit anti-allergy effects in many clinical trials. This systematic review will assess the effectiveness, and safety of acupuncture for anxiety treatment. METHODS:Eleven databas...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010266

    authors: Choi SY,Kim GW

    更新日期:2018-04-01 00:00:00

  • Clinico-radiologic features of molar-incisor malformation in a case series of 38 patients: A retrospective observational study.

    abstract::Molar-incisor malformation (MIM) is a recently defined dental abnormality of molar root and incisors, and introduced as one of the causes of periapical and periodontal abscess. The purpose of this study was to investigate the clinical and radiological features of MIM, with special emphasis on various medical history. ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017356

    authors: Kim JE,Hong JK,Yi WJ,Heo MS,Lee SS,Choi SC,Huh KH

    更新日期:2019-10-01 00:00:00

  • Increased serum brain-derived neurotrophic factor in male schizophrenic patients with metabolic syndrome.

    abstract::Increased prevalence of metabolic syndrome was found in patients with schizophrenia. Brain-derived neurotrophic factor (BDNF) was involved in energy metabolism and the pathophysiology of schizophrenia, but differently in males and females. We aimed to investigate the serum BDNF levels in patients with schizophrenia wi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007089

    authors: Lin CC,Hung YY,Tsai MC,Huang TL

    更新日期:2017-06-01 00:00:00