Abstract:
BACKGROUND:This research aims to assess the response to acid suppression therapy in gastroesophageal reflux disease (GERD)-related chronic laryngitis (CL). METHODS:Data were extracted from Web of Knowledge, Embase, and PubMed for English language article published up to March 2016. Pooled overall response rate (ORR) rates were evaluated to determine acid suppression treatment efficacy. Random effects model was used with standard approaches to sensitivity analysis, quality assessment, heterogeneity, and exploration of publication bias. RESULTS:Pooled data from 21 reports (N = 2864, antireflux medicine: 2741; antireflux surgery: 123, study duration 4-108 week) were analyzed. With the random-effect model, the ORR was 66% (95% confidence interval [CI] 54%-78%). The ORRs were 80% for antireflux surgery (95% CI 67%-93%, 3 studies, 123 patients), whereas 64% for antireflux medicine (95% CI 50%-77%, 18 studies, 2741 patients), and the ORR was 70% (95% CI 55%-85%, 15 reports, 2731 patients) for >8 weeks' therapy duration, whereas 57% (95% CI 48%-65%, 6 reports, 133 patients) for ≤8 weeks' duration of therapy. CONCLUSIONS:Acid suppression seems to be an effective therapy for GERD-related CL. There was an increase in effect among patients with surgery therapeutic method and longer therapy duration.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Yang Y,Wu H,Zhou Jdoi
10.1097/MD.0000000000004868subject
Has Abstractpub_date
2016-10-01 00:00:00pages
e4868issue
40eissn
0025-7974issn
1536-5964pii
00005792-201610040-00022journal_volume
95pub_type
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