Abstract:
:Melanoma differentiation-associated protein 5 (MDA-5) is a novel autoantibody frequently characterized by interstitial lung disease and a distinct cutaneous phenotype with palmar papules, ulceration, and rash. Virtually all patients have underlying dermatomyositis, but many lack the characteristic clinical myopathy associated with it. In the setting of amyopathic disease, the absence of clinically available biomarkers or clear pathologic diagnosis can complicate effective prognostic and therapeutic intervention. Until recently the presence of MDA-5 antibody associated dermato-pulmonary syndrome was described only in Asian populations. We present 2 cases of MDA-5-associated dermato-pulmonary syndrome and provide a comprehensive review of available literature.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Chaisson NF,Paik J,Orbai AM,Casciola-Rosen L,Fiorentino D,Danoff S,Rosen Adoi
10.1097/MD.0b013e3182606f0bsubject
Has Abstractpub_date
2012-07-01 00:00:00pages
220-228issue
4eissn
0025-7974issn
1536-5964pii
00005792-201207000-00006journal_volume
91pub_type
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