Abstract:
RATIONALE:Tyrosine kinase inhibitors (TKIs) are known to have greater efficacy in epidermal growth factor receptor (EGFR) mutation nonsmall cell lung cancer (NSCLC). However, about 10% of EGFR wild-type (wt) patients respond to TKIs. PATIENT CONCERNS:Several strategies to increase the efficacy of TKIs in wt NSCLC are the subjects of ongoing investigations. One of them is combining EGFR TKI with intercalated chemotherapy. DIAGNOSES:We describe a patient with EGFR wt NSCLC, who was found with ovarian and lung metastasis, was treated with pemetrexed and intercalated icotinib. INTERVENTIONS:In this case, we reported the successful long-term maintenance treatment of a patient with EGFR wt NSCLC with pemetrexed and Icotinib. The patient (40-year-old female) was found with ovarian masses and lung masses. Pathological, immunohistochemical, and amplification refractory mutation system (ARMS) assay examinations of ovarian specimen suggested the expression of metastatic lung adenocarcinoma with wt EGFR. After failure treatment with paclitaxel-carboplatin, the patient received 4 cycles of pemetrexed plus platinum with intercalated icotinib and then remained on pemetrexed and icotinib. OUTCOMES:A partial response was achieved after the treatment. The patient's condition had remained stable on pemetrexed and icotinib for more than 20 months, with no evidence of progression. LESSONS:To our knowledge, this is the first report using the long-term maintenance treatment with pemetrexed and intercalated icotinib in EGFR wt patient. The therapeutic strategies warrant further exploration in selected populations of NSCLC.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Xu T,Wu H,Jin S,Min H,Zhang Z,Shu Y,Wen W,Guo Rdoi
10.1097/MD.0000000000007732subject
Has Abstractpub_date
2017-08-01 00:00:00pages
e7732issue
33eissn
0025-7974issn
1536-5964pii
00005792-201708180-00017journal_volume
96pub_type
杂志文章相关文献
MEDICINE文献大全abstract:INTRODUCTION:Bardet-Biedl syndrome, which compromises airway management and the cardiovascular and renal systems, is a rare ciliopathic syndrome characterized by multisystem involvement and varying genetic etiologies and clinical manifestations. PATIENT CONCERNS:A 13-year-old female patient had a history of chronic re...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022300
更新日期:2020-09-18 00:00:00
abstract:OF BACKGROUND DATA:There is growing interest in identifying nutritional biomarkers associated with poor outcomes of elective spine surgery. Prealbumin and transferrin are both biomarkers of nutritional status that can be obtained from clinical laboratories. However, associations of preoperative measures of these nutrit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014741
更新日期:2019-03-01 00:00:00
abstract:INTRODUCTION:Carcinoid tumor is one of the most frequent neuroendocrine tumors, and the majority of which are usually observed in the lungs and gastrointestinal tract. The prevalence of ovarian carcinoids is merely 0.1% in ovarian neoplasms and 1% in carcinoid tumors. We described 2 rare cases in our hospital of primar...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000021109
更新日期:2020-10-02 00:00:00
abstract::Pyogenic sacroiliitis is exceptional in very young children. Diagnosis is difficult because clinical examination is misleading. FABER test is rarely helpful in very young children. Inflammatory syndrome is frequent. Bone scintigraphy and MRI are very sensitive for the diagnosis. Joint fluid aspiration and blood cultur...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000001581
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:To assess the safety and efficacy of percutaneous short-segment pedicle instrumentation compared with conventionally open short-segment pedicle instrumentation and provide recommendations for using these procedures to treat thoracolumbar fractures. METHODS:The Medline database, Cochrane database of Systemat...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000012535
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Pancreatic cancer (PC) remains difficult to treat, despite the recent advances in various anticancer therapies. Immuno-inflammatory response is considered to be a major risk factor for the development of PC in addition to a combination of genetic background and environmental factors. Although patients with P...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000005541
更新日期:2016-12-01 00:00:00
abstract::Cancer stem cells (CSCs) are thought to be responsible for tumor relapse and metastasis due to their abilities to self-renew, differentiate, and give rise to new tumors. Cyclooxygenase-2 (COX-2) is highly expressed in several kinds of CSCs, and it helps promote stem cell renewal, proliferation, and radioresistance. Wh...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001806
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:To find out whether the intramedullary fixations are superior to the extramedullary fixations in treating unstable femoral intertrochanteric fractures (UFIFs). METHODS:The meta-analysis of randomized controlled trials (RCTs) was conducted by searching the PubMed, Cochrane Library, and Embase databases to evalu...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000017010
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Chronic low back pain (CLBP) is a clinically common and recurrent disease. However, many trials have shown that auriculotherapy (AT) can effectively treat CLBP. There are currently no systematic reviews of this therapy. The plan aims to evaluate the effectiveness and safety of this treatment in patients with...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019722
更新日期:2020-04-01 00:00:00
abstract::The purpose of this study was to investigate the association of herpes zoster infection with peptic ulcer disease in a Korean population.The Korean National Health Insurance Service selects samples directly from the entire Korean population database, and 1,125,691 participants with 114,369,638 medical claim codes were...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019318
更新日期:2020-02-01 00:00:00
abstract::The aim of this study was to compare bone mineral densities (BMDs) and body composition between Southeast Asia college students and Chinese college students, in order to provide a certain reference enhancing college students' physical fitness.A total of 1694 Chinese college students (294 men and 1400 women, aged 18-22...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004724
更新日期:2016-09-01 00:00:00
abstract::To our knowledge, the association between antidepressant exposure and endometrial cancer has not been previously explored. Herein, we aim to investigate the association between antidepressant prescription, including novel antidepressants, and the risk for endometrial cancer in a population-based study.Data for the ana...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004178
更新日期:2016-07-01 00:00:00
abstract:RATIONALE:Although several studies have described the involvement pattern of myotonic dystrophy type 1 (DM1) using muscle MRI, most of these studies have limitations as cross-sectional studies. To the best of our knowledge, there have been no reports of longitudinal studies describing muscle involvement patterns in pat...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009379
更新日期:2018-01-01 00:00:00
abstract::Like research in general internal medicine, family medicine research can play an important role in improving medical knowledge. We aimed to compare articles published in family medicine journals with articles published in general internal medicine journals. In this bibliometric study, we retrieved 658 randomly selecte...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020586
更新日期:2020-06-12 00:00:00
abstract:INTRODUCTION:Treating blood stasis is effective in treating obesity and metabolic diseases in traditional Korean medicine. The aim of this prospective observational study is to determine the effectiveness of the diagnosis index for metabolic diseases with blood stasis by analyzing clinical data and blood samples. METH...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000021140
更新日期:2020-07-02 00:00:00
abstract:BACKGROUND:Drug resistant epilepsy (DRE) is very common among children and adults and studies had found some related risk factors for DRE, while the results were not consistent. The aim of this study was to identify risk factors for drug-resistant epilepsy. METHODS:Three electronic databases (Medline, Embase and Cochr...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016402
更新日期:2019-07-01 00:00:00
abstract:UNLABELLED:Melanoma is a treatable and preventable skin cancer. It is responsible for 75% of deaths among all skin cancers. Previous studies have found that race/ethnicity may play a role in survival among melanoma patients. However, there are no studies that cover 30 years and take race into account for the U.S. POPU...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003315
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:The correlation between single nucleotide polymorphism (SNP) rs12807809 in Neurogranin (NRGN) gene and Schizophrenia (SCZ) was investigated by several studies, whereas the results were conflicting. Thus, we performed the present meta-analysis to combine and analyze the available studies in order to provide a...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000018518
更新日期:2019-12-01 00:00:00
abstract:RATIONALE:Mucocele is a disease lined primarily by epithelium, and occurs mainly when the sinus ostium is obstructed. PATIENT CONCERNS:We report a case of a 37-year-old man who presented with painless proptosis of the right eye and diplopia. DIAGNOSES:The preoperative finding was mucocele of the ethmoid sinus. INTER...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009353
更新日期:2017-12-01 00:00:00
abstract:RATIONALE:Pulmonary embolism can manifest by a myriad of clinical symptoms. High grade fever is a rare presentation of thromboembolic phenomenon. PATIENT CONCERNS:A middle aged woman presented with high grade fevers. DIAGNOSES:Patient remained febrile despite broad spectrum antibiotics. All cultures were negative. CT...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010002
更新日期:2018-03-01 00:00:00
abstract::Systemic vasculitis (SV) involving abdominal structures usually has a poor prognosis. Gallbladder vasculitis (GV) has been reported as part of SV (GB-SV) and focal single-organ vasculitis (GB-SOV). We analyzed clinical and histologic characteristics of patients with GV to identify features that differentiate GB-SOV fr...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000205
更新日期:2014-11-01 00:00:00
abstract::To study the correlation between single nucleotide polymorphism (SNP) of the 3' untranslated region (UTR) rs9722 locus in S100B and the risk of chronic heart failure (CHF), plasma levels of S100B protein as well as has-miR-340-3p in a Chinese Han population.A total of 215 patients with CHF (124 ischemic cardiomyopathy...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021018
更新日期:2020-06-26 00:00:00
abstract::Concomitant influenza and cryptococcal infections are rare. Herein, we describe an unusual case of an avian influenza A (H7N9) infection with several severe mixed bacterial infections and systemic super-infection with Cryptococcus neoformans presenting as ventilator-associated pneumonia (VAP) and bloodstream infection...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000015544
更新日期:2019-05-01 00:00:00
abstract::There is an increased interest in extending surgical criteria for pancreatic cancer by performing pancreaticoduodenectomy (PD) combined with portal vein (PV) or superior mesenteric vein (SMV) resection and reconstruction for borderline resectable patients. However, whether this procedure suitable for elderly patients ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007335
更新日期:2017-07-01 00:00:00
abstract::Systemic activation of hemostasis and thrombosis has been implicated in tumor progression and metastasis. D-dimer has been used as an indicator for the thrombosis. Here, we investigated the role of the activation of coagulation in patients with metastatic gastric cancer by measuring D-dimer level.We conducted an obser...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000951
更新日期:2015-07-01 00:00:00
abstract::Satisfaction with life in the case of nurses is closely related to their professional work and is an important factor affecting the quality of work and patient care.An analysis of the readiness of Polish nurses depending on the level of life satisfaction.The study was conducted from January to November 2016 in randoml...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012129
更新日期:2018-09-01 00:00:00
abstract::This research aims to explore the accurate incidence, severity and outcomes of dysphagia and dysphonia after Hangman fractures.A total of 93 patients were included in this study and clinical data were reviewed. The Bazaz grading system (0-None; 1-Mild; 2-Moderate; 3-Severe) was used for dysphagia evaluation and the Vo...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013552
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:National Comprehensive Cancer Network (NCCN) guidelines recommend surgery, chemotherapy, and radiation therapy for gastric cancer patients. Neoadjuvant treatments as the administration of therapeutic agents before a main treatment gained in more and more attention. However, the role of neoadjuvant treatments...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000010392
更新日期:2018-04-01 00:00:00
abstract::Methemoglobin is a form of hemoglobin that does not bind oxygen. When its concentration is elevated in red blood cells, functional anemia and tissue hypoxia may occur. We performed a retrospective case series to describe the cases of acquired methemoglobinemia (methemoglobin level >2%) detected and the clinical circum...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/01.md.0000141096.00377.3f
更新日期:2004-09-01 00:00:00
abstract::The aim of this study was to assess the levels of self-perceived burden (SPB) and self-management behavior in elderly stroke survivors during the first 3 months after acute stroke, and to explore the correlation between them.A total of 203 consecutive hospitalized elderly patients diagnosed with stroke were recruited....
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022862
更新日期:2020-10-30 00:00:00