Convergent changes in muscle metabolism depend on duration of high-altitude ancestry across Andean waterfowl.

abstract：:Glucocorticoid receptors (GR) have diverse functions relevant to maintenance of homeostasis and adaptation to environmental challenges. Understanding the importance of tissue-specific GR function in physiology and behavior has been hampered by near-ubiquitous localization in brain and body. Here we use CRISPR/Cas9 gen...

journal_title：eLife

authors： Scheimann JR,Moloney RD,Mahbod P,Morano RL,Fitzgerald M,Hoskins O,Packard BA,Cotella EM,Hu YC,Herman JP

更新日期：2019-07-22 00:00:00

abstract：:The phylogenetic placement of the morphologically simple placozoans is crucial to understanding the evolution of complex animal traits. Here, we examine the influence of adding new genomes from placozoans to a large dataset designed to study the deepest splits in the animal phylogeny. Using site-heterogeneous substitu...

journal_title：eLife

authors： Laumer CE,Gruber-Vodicka H,Hadfield MG,Pearse VB,Riesgo A,Marioni JC,Giribet G

更新日期：2018-10-30 00:00:00

abstract：: ...

journal_title：eLife

authors： Zhou FY,Ruiz-Puig C,Owen RP,White MJ,Rittscher J,Lu X

更新日期：2019-07-02 00:00:00

abstract：:Rapid diagnostic tests (RDTs) have transformed malaria diagnosis. The most prevalent P. falciparum RDTs detect histidine-rich protein 2 (PfHRP2). However, pfhrp2 gene deletions yielding false-negative RDTs, first reported in South America in 2010, have been confirmed in Africa and Asia. We developed a mathematical mod...

journal_title：eLife

authors： Watson OJ,Slater HC,Verity R,Parr JB,Mwandagalirwa MK,Tshefu A,Meshnick SR,Ghani AC

更新日期：2017-08-24 00:00:00

abstract：:How mammalian tissues maintain their architecture and tissue-specificity is poorly understood. Previously, we documented both the indispensable role of the extracellular matrix (ECM) protein, laminin-111 (LN1), in the formation of normal breast acini, and the phenotypic reversion of cancer cells to acini-like structur...

journal_title：eLife

authors： Furuta S,Ren G,Mao JH,Bissell MJ

更新日期：2018-03-21 00:00:00

abstract：:To efficiently navigate through the environment and avoid potential threats, an animal must quickly detect the motion of approaching objects. Current models of primate vision place the origins of this complex computation in the visual cortex. Here, we report that detection of approaching motion begins in the retina. S...

journal_title：eLife

authors： Appleby TR,Manookin MB

更新日期：2020-02-24 00:00:00

abstract：:Studies in different animal model systems have revealed the impact of odors on immune cells; however, any understanding on why and how odors control cellular immunity remained unclear. We find that Drosophila employ an olfactory-immune cross-talk to tune a specific cell type, the lamellocytes, from hematopoietic-proge...

journal_title：eLife

authors： Madhwal S,Shin M,Kapoor A,Goyal M,Joshi MK,Ur Rehman PM,Gor K,Shim J,Mukherjee T

更新日期：2020-12-29 00:00:00

abstract：:Unfavorable redox conditions in the endoplasmic reticulum (ER) can decrease the capacity for protein secretion, altering vital cell functions. While systems to manage reductive stress are well-established, how cells cope with an overly oxidizing ER remains largely undefined. In previous work (Wang et al., 2014), we de...

journal_title：eLife

authors： Siegenthaler KD,Pareja KA,Wang J,Sevier CS

更新日期：2017-03-03 00:00:00

abstract：:To understand the neural origins of rhythmic behavior one must characterize the central pattern generator circuit and quantify the population size needed to sustain functionality. Breathing-related interneurons of the brainstem pre-Bötzinger complex (preBötC) that putatively comprise the core respiratory rhythm genera...

journal_title：eLife

authors： Wang X,Hayes JA,Revill AL,Song H,Kottick A,Vann NC,LaMar MD,Picardo MC,Akins VT,Funk GD,Del Negro CA

更新日期：2014-07-15 00:00:00

abstract：:Mitogen-activated protein kinases (MAPK) such as p38 and the c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals. Their activity is regulated by the MAPK-phosphatase 1 (DUSP1), a key component of the anti-inflammatory response. Stress kinases are well-described elements of the ...

journal_title：eLife

authors： Celaya AM,Sánchez-Pérez I,Bermúdez-Muñoz JM,Rodríguez-de la Rosa L,Pintado-Berninches L,Perona R,Murillo-Cuesta S,Varela-Nieto I

更新日期：2019-04-02 00:00:00

abstract：:We aimed to study time trends and levels of mean total cholesterol and lipid fractions, and dyslipidaemias prevalence in Latin America and the Caribbean (LAC). Systematic-review and meta-analysis of population-based studies in which lipid (total cholesterol [TC; 86 studies; 168,553 people], HDL-Cholesterol [HDL-C; 84 ...

journal_title：eLife

authors： Carrillo-Larco RM,Benites-Moya CJ,Anza-Ramirez C,Albitres-Flores L,Sánchez-Velazco D,Pacheco-Barrios N,Bernabe-Ortiz A

更新日期：2020-08-18 00:00:00

abstract：:Excitatory and inhibitory synapses are the brain's most abundant synapse types. However, little is known about their formation during critical periods of motor skill learning, when sensory experience defines a motor target that animals strive to imitate. In songbirds, we find that exposure to tutor song leads to elimi...

journal_title：eLife

authors： Huang Z,Khaled HG,Kirschmann M,Gobes SM,Hahnloser RH

更新日期：2018-10-25 00:00:00

abstract：:Spore killers in fungi are selfish genetic elements that distort Mendelian segregation in their favor. It remains unclear how many species harbor them and how diverse their mechanisms are. Here, we discover two spore killers from a natural isolate of the fission yeast Schizosaccharomyces pombe. Both killers belong to ...

journal_title：eLife

authors： Hu W,Jiang ZD,Suo F,Zheng JX,He WZ,Du LL

更新日期：2017-06-20 00:00:00

abstract：:Organisms possessing genetic codes with unassigned codons raise the question of how cellular machinery resolves such codons and how this could impact horizontal gene transfer. Here, we use a genomically recoded Escherichia coli to examine how organisms address translation at unassigned UAG codons, which obstruct propa...

journal_title：eLife

authors： Ma NJ,Hemez CF,Barber KW,Rinehart J,Isaacs FJ

更新日期：2018-10-30 00:00:00

abstract：:Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPɑ contributes to the progressive brain disease CLN4. ...

journal_title：eLife

authors： Berryer MH,Kosmaczewski SG,Barrett LE

更新日期：2019-12-06 00:00:00

abstract：:R-loops are features of chromatin consisting of a strand of DNA hybridized to RNA, as well as the expelled complementary DNA strand. R-loops are enriched at promoters where they have recently been shown to have important roles in modifying gene expression. However, the location of promoter-associated R-loops and the g...

journal_title：eLife

authors： Dumelie JG,Jaffrey SR

更新日期：2017-10-26 00:00:00

abstract：:A polymorphism in the autophagy gene Atg16l1 is associated with susceptibility to inflammatory bowel disease (IBD); however, it remains unclear how autophagy contributes to intestinal immune homeostasis. Here, we demonstrate that autophagy is essential for maintenance of balanced CD4(+) T cell responses in the intesti...

journal_title：eLife

authors： Kabat AM,Harrison OJ,Riffelmacher T,Moghaddam AE,Pearson CF,Laing A,Abeler-Dörner L,Forman SP,Grencis RK,Sattentau Q,Simon AK,Pott J,Maloy KJ

更新日期：2016-02-24 00:00:00

abstract：:Macrophage-mediated phagocytosis and cytokine production represent the front lines of resistance to bacterial invaders. A key feature of this pro-inflammatory response in mammals is the complex remodeling of cellular metabolism towards aerobic glycolysis. Although the function of bactericidal macrophages is highly con...

journal_title：eLife

authors： Krejčová G,Danielová A,Nedbalová P,Kazek M,Strych L,Chawla G,Tennessen JM,Lieskovská J,Jindra M,Doležal T,Bajgar A

更新日期：2019-10-14 00:00:00

abstract：:Temporary circuits amplify spontaneous activity in the visual system of neonatal rats. ...

journal_title：eLife

authors： Fogerson PM,Huguenard JR

更新日期：2016-10-11 00:00:00

abstract：:Many primary sensory cilia exhibit unique architectures that are critical for transduction of specific sensory stimuli. Although basic ciliogenic mechanisms are well described, how complex ciliary structures are generated remains unclear. Seminal work performed several decades ago provided an initial but incomplete de...

journal_title：eLife

authors： Doroquez DB,Berciu C,Anderson JR,Sengupta P,Nicastro D

更新日期：2014-03-25 00:00:00

abstract：:Plasma Membrane is the primary structure for adjusting to ever changing conditions. PM sub-compartmentalization in domains is thought to orchestrate signaling. Yet, mechanisms governing membrane organization are mostly uncharacterized. The plant-specific REMORINs are proteins regulating hormonal crosstalk and host inv...

journal_title：eLife

authors： Gronnier J,Crowet JM,Habenstein B,Nasir MN,Bayle V,Hosy E,Platre MP,Gouguet P,Raffaele S,Martinez D,Grelard A,Loquet A,Simon-Plas F,Gerbeau-Pissot P,Der C,Bayer EM,Jaillais Y,Deleu M,Germain V,Lins L,Mongrand S

更新日期：2017-07-31 00:00:00

abstract：:Microtubule dynamics facilitate neurite growth and establish morphology, but the role of minus-end binding proteins in these processes is largely unexplored. CAMSAP homologs associate with microtubule minus-ends, and are important for the stability of epithelial cell adhesions. In this study, we report morphological d...

journal_title：eLife

authors： Marcette JD,Chen JJ,Nonet ML

更新日期：2014-02-25 00:00:00

abstract：:Cell growth and/or proliferation may require the reprogramming of metabolic pathways, whereby a switch from oxidative to glycolytic metabolism diverts glycolytic intermediates towards anabolic pathways. Herein, we identify a novel role for TRIM32 in the maintenance of glycolytic flux mediated by biochemical interactio...

journal_title：eLife

authors： Bawa S,Brooks DS,Neville KE,Tipping M,Sagar MA,Kollhoff JA,Chawla G,Geisbrecht BV,Tennessen JM,Eliceiri KW,Geisbrecht ER

更新日期：2020-03-30 00:00:00

abstract：:Two different cell signals often affect transcription of the same gene. In such cases, it is natural to ask how the combined transcriptional response compares to the individual responses. The most commonly used mechanistic models predict additive or multiplicative combined responses, but a systematic genome-wide evalu...

journal_title：eLife

authors： Sanford EM,Emert BL,Coté A,Raj A

更新日期：2020-12-07 00:00:00

abstract：:Aging is an intricate phenomenon associated with the gradual loss of physiological functions, and both nutrient sensing and proteostasis control lifespan. Although multiple approaches have facilitated the identification of candidate genes that govern longevity, the molecular mechanisms that link aging pathways are sti...

journal_title：eLife

authors： Chen YC,Jiang PH,Chen HM,Chen CH,Wang YT,Chen YJ,Yu CJ,Teng SC

更新日期：2018-12-05 00:00:00

abstract：:Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. Here, we demonstrate that chromatin-associated RNA contributes to the stable association of SUV39H...

journal_title：eLife

authors： Johnson WL,Yewdell WT,Bell JC,McNulty SM,Duda Z,O'Neill RJ,Sullivan BA,Straight AF

更新日期：2017-08-01 00:00:00

abstract：:In recent years, functional genomics approaches combining genetic information with bulk RNA-sequencing data have identified the downstream expression effects of disease-associated genetic risk factors through so-called expression quantitative trait locus (eQTL) analysis. Single-cell RNA-sequencing creates enormous opp...

journal_title：eLife

authors： van der Wijst M,de Vries DH,Groot HE,Trynka G,Hon CC,Bonder MJ,Stegle O,Nawijn MC,Idaghdour Y,van der Harst P,Ye CJ,Powell J,Theis FJ,Mahfouz A,Heinig M,Franke L

更新日期：2020-03-09 00:00:00

abstract：:WNK1, a kinase that controls kidney salt homeostasis, also regulates adhesion and migration in CD4+ T cells. Wnk1 is highly expressed in thymocytes, and since migration is important for thymocyte maturation, we investigated a role for WNK1 in mouse thymocyte development. We find that WNK1 is required for the transitio...

journal_title：eLife

authors： Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

更新日期：2020-10-14 00:00:00

abstract：:It is widely argued that personalized instruction based on individual differences in learning styles or genetic predispositions could improve learning outcomes. However, this proposition has resisted clear demonstration in human studies, where it is difficult to control experience and quantify outcomes. Here, we take ...

journal_title：eLife

authors： Mets DG,Brainard MS

更新日期：2019-09-17 00:00:00

abstract：:Experience-dependent reorganisation of functional maps in the cerebral cortex is well described in the primary sensory cortices. However, there is relatively little evidence for such cortical reorganisation over the short-term. Using human somatosensory cortex as a model, we investigated the effects of a 24 hr gluing ...

journal_title：eLife

authors： Kolasinski J,Makin TR,Logan JP,Jbabdi S,Clare S,Stagg CJ,Johansen-Berg H

更新日期：2016-12-30 00:00:00