Abstract:
BACKGROUND:Recent studies have confirmed that immune-associated genes perform a crucial function in recurrence and metastasis of thyroid carcinoma. A reliable immune-related prognostic signature for patients with thyroid cancer is needed. This study constructed a novel immune-related prognostic signature for thyroid cancer and evaluated its prognostic value by bioinformatics analysis. METHODS:In this study, we anatomized differentially expressed immune-associated genes from The Cancer Genome Atlas database. The samples from The Cancer Genome Atlas database were randomly divided into training set and test set. A novel immune-related prognostic signature for thyroid cancer was developed by least absolute shrinkage and selection operator and Cox regression analysis: Risk score = (0.6846 × expression value of C-X-C motif chemokine ligand 5 [CXCL5]) + (1.1556 × expression value of Azurocidin 1 [AZU1]) + (-0.3156 × expression value of nucleotide binding oligomerization domain containing 1 [NOD1] + (0.0542 × expression value of TNF Receptor Superfamily Member 11b [TNFRSF11B]) + (0.0952 × expression value of VGF nerve growth factor inducible [VGF]). The established prognostic signature was evaluated based on training set and test set by survival curves, receiver-operator characteristic curves, risk score, survival status, heatmap, and independent prognostic analysis. Meanwhile, we appraised the correlation between target immune-associated genes and clinical stage, tumor-infiltrating immune cells respectively. RESULTS:Five immune-associated genes were used for constructing an immune-related prognostic signature by least absolute shrinkage and selection operator, univariate, and multivariate analysis. Survival curves, receiver-operator characteristic curves, and independent prognostic analysis showed the signature had significant prediction value. Clinical and immune cell correlation analyses indicated that target immune-associated genes may participate in tumor immune infiltration and tumor progression. CONCLUSIONS:We constructed a novel 5 immune-associated genes signature for predicting the prognosis of patients with thyroid cancer, which may help clinical workers evaluate individualized therapy and prognosis.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Xue Y,Li J,Lu Xdoi
10.1177/1533033820935860subject
Has Abstractpub_date
2020-01-01 00:00:00pages
1533033820935860eissn
1533-0346issn
1533-0338journal_volume
19pub_type
杂志文章abstract::A specific protein profile that accompanies neoplastic transformation in the premalignant airway epithelium could provide an opportunity for early diagnosis of lung cancer. The aim of this study was to screen and identify early candidate biomarkers of non-small cell lung cancer. Thirteen non-small cell lung cancer sam...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533034615627391
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:To confirm the feasibility and accuracy of the method for evaluating blood supply and embolization rate of liver cancer based on I-flow software through animal experiments and clinical study. METHODS:Rabbits underwent selective angiography under different perfusion conditions in the same kidney. The blood su...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/1533033820970665
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abstract::Electrochemotherapy is an effective antitumor treatment employing locally applied high voltage electric pulses delivered through conductive electrodes to the tumor in combination with chemotherapeutic drugs. The efficiency of electrochemotherapy strongly depends on the local electric field distribution inside the targ...
journal_title:Technology in cancer research & treatment
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doi:10.1177/153303460800700507
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abstract:INTRODUCTION:Rectal cancer ranks as the eighth in cancer-related morbidity and the tenth in the cancer-related mortality. A few studies have explored several biomarkers for colorectal cancer. However, there is still a great need for us to excavate novel biomarkers with effective and efficient diagnostic and prognostic ...
journal_title:Technology in cancer research & treatment
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doi:10.1177/1533033820973270
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abstract:PURPOSE:To assess the efficacy of stereotactic body radiotherapy in patients with unresectable locally advanced pancreatic cancer. MATERIALS AND METHODS:All patients received a prescription dose of 45 Gy in 6 fractions. Primary end point was freedom from local progression. Secondary end points were overall survival, p...
journal_title:Technology in cancer research & treatment
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abstract:OBJECTIVE:The aim of this study was to evaluate the mechanisms involved with miRNA-708 and its targeting of bone morphogenetic protein and activin membrane-bound inhibitor in cell proliferation, migration, and apoptosis in mice with melanoma via the Wnt and transforming growth factor β signaling pathways. METHODS:Sixt...
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abstract::Irreversible electroporation (IRE) has been shown to be an effective method of killing cells locally. In contrast to radiofrequency ablation, the mechanism by which cells are thought to die via IRE is the creation of pores in cell membranes, without substantial increase in tissue temperature. To determine the degree t...
journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
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journal_title:Technology in cancer research & treatment
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更新日期:2005-12-01 00:00:00
abstract::Chemo-radiotherapy is standard treatment of stage IIIA-N2 bulky or IIIB non-small cell lung cancer (NSCLC). Surgical resection of residual disease in downstaged patients may improve overall survival. In this setting, restaging disease is still a challenge. 18F-FDG PET/CT represents the gold standard although accuracy ...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.7785/tcrt.2012.500437
更新日期:2015-12-01 00:00:00
abstract::Our results indicate that the surface chemistry, composition, and 3-D structure of nanoparticles are critical in determining their in vivo biodistribution, and therefore the efficacy of nanodevice imaging and therapies. We demonstrate that gold/dendrimer nanocomposites in vivo, present biodistribution characteristics ...
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doi:10.1177/153303460500400604
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
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更新日期:2018-01-01 00:00:00
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journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
abstract::Stereotactic body radiation therapy is a well-tolerated modality for the treatment of primary and metastatic liver lesions, and fiducials are often used as surrogates for tumor tracking during treatment. We evaluated respiratory-induced liver deformation by measuring the rigidity of the fiducial configuration during t...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
doi:10.1177/153303460500400503
更新日期:2005-10-01 00:00:00
abstract::The treatment of patients with malignant brain tumors, in particular glioblastoma multiforme (GBM) is very challenging because of their diffuse infiltrative nature and the cytological heterogeneity. The median survival of patients with newly diagnosed GBM is only 12-15 months, and only 8-12% of them survive for two ye...
journal_title:Technology in cancer research & treatment
pub_type: 杂志文章,评审
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更新日期:2006-06-01 00:00:00
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journal_title:Technology in cancer research & treatment
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journal_title:Technology in cancer research & treatment
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00