Identifications of Candidate Genes Significantly Associated With Rectal Cancer by Integrated Bioinformatics Analysis.

Abstract:

INTRODUCTION:Rectal cancer ranks as the eighth in cancer-related morbidity and the tenth in the cancer-related mortality. A few studies have explored several biomarkers for colorectal cancer. However, there is still a great need for us to excavate novel biomarkers with effective and efficient diagnostic and prognostic values to discover the etiology and pathogenesis of rectal cancer separately. Therefore, we aimed to identify more novel candidate genes that were significantly associated with rectal cancer through integrated bioinformatics analysis. METHODS:We analyzed the gene expression profiles of GSE15781 and GSE20842 from Gene Expression Omnibus database to identify differentially expressed genes between normal rectal tissue and rectal cancer tissue. RESULTS:We searched for core genes, carried out survival analysis and analyzed the expressions of core genes. We found that 142 genes were significantly upregulated, and 229 genes were significantly downregulated in all 3 independent studies. In KEGG analysis, the upregulated genes were significantly enriched in cytokine-cytokine receptor interaction, IL-17 signaling pathway, cell cycle, etc. The downregulated genes were primarily enriched in nitrogen metabolism, mineral absorption and pentose and glucuronate interconversions. Inhibin subunit beta B (INHBB) expressed markedly higher in rectal cancer tissues compared with normal tissues, and claudins (CLDN) 23 expressed significantly lower in rectal cancer tissues. CONCLUSION:In conclusion, we discovered that INHBB could provide a great significant diagnostic and prognostic values for rectal cancer.

authors

Xu Z,Li Y,Cui Y,Guo Y

doi

10.1177/1533033820973270

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

1533033820973270

eissn

1533-0346

issn

1533-0338

journal_volume

19

pub_type

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