Abstract:
BACKGROUND:Magnetic resonance imaging (MRI) T1 relaxometry (mapping) has been reported as a quantitative biomarker of liver injury due to inflammation and fibrosis. OBJECTIVE:To assess the relationship between liver MRI T1 relaxometry measurements obtained using a modified Look-Locker inversion recovery (MOLLI) pulse sequence without and with iron (T2*) correction (cT1) in pediatric autoimmune liver disease. MATERIALS AND METHODS:This cross-sectional study was institutional review board-approved, with informed consent obtained. MRI was acquired at 1.5 T in patients participating in an autoimmune liver disease registry. T1 relaxometry was performed using a MOLLI sequence with a 5(3)3-s acquisition strategy. A multi-echo gradient echo sequence was used to measure liver T2*. Non-iron-corrected native T1 (ms), calculated as the mean of four slices through the mid-liver, was measured using T1 parametric maps generated off-line. A proprietary T2* correction (Perspectum Diagnostics, Oxford, UK), blinded to native T1 values, calculated cT1 values. The relationship between native T1 and cT1 measurements was assessed using Spearman rank correlation and Bland-Altman analyses. RESULTS:Forty-eight patients with a mean (standard deviation [SD]) age of 15.2 (4.1) years were included. Mean (SD) liver native T1 was 651.2 (123.9) ms and mean (SD) cT1 was 919.5 (86.8) ms, with excellent positive correlation between values (r=0.91 [95% confidence interval (CI): 0.85-0.95]; P<0.0001). Mean bias between native T1 and cT1 measurements was 268.3 ms (95% limits of agreement: 131.9-404.7 ms). CONCLUSION:There is excellent positive correlation between liver native T1 and cT1 measurements in pediatric patients with autoimmune liver disease. This relationship brings into question the need to perform T1 iron correction in this patient population. T1 and cT1 measurements are not interchangeable, however, due to considerable systematic bias with cT1 values being considerably higher.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Dillman JR,Serai SD,Miethke AG,Singh R,Tkach JA,Trout ATdoi
10.1007/s00247-020-04663-8subject
Has Abstractpub_date
2020-06-01 00:00:00pages
935-942issue
7eissn
0301-0449issn
1432-1998pii
10.1007/s00247-020-04663-8journal_volume
50pub_type
杂志文章abstract:OBJECTIVE:To evaluate the effectiveness of lateral decubitus high-resolution CT (HRCT) in detecting air trapping in children. MATERIALS AND METHODS:HRCT scans of 21 children with heterogeneous lung attenuation caused by air trapping (n = 10) or with infiltrative lung disease (n = 11) were reviewed retrospectively. The...
journal_title:Pediatric radiology
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doi:10.1007/s00247-001-0622-2
更新日期:2002-03-01 00:00:00
abstract::Paediatric post-traumatic cortical defects, although rare, are predominately seen affecting the distal radius following a greenstick or torus fracture. We review the literature and present a further two cases supported by CT and MRI. Images from an acute greenstick fracture are also presented to help understand the pa...
journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-001-0608-0
更新日期:2002-05-01 00:00:00
abstract::We describe a 4-year-old girl with an inflammatory pseudotumour of the pancreas, which was preceded by varicella-zoster infection. Inflammatory pseudotumour may involve a variety of tissues, the lungs and liver being typical sites of predilection. Imaging and laboratory tests are nonspecific, and for this reason the d...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470000331
更新日期:2000-11-01 00:00:00
abstract::Cranial ultrasound on neonatal intensive care units is generally performed by intensive care physicians, but radiologists often provide this crucial bedside test to children on specialist paediatric cardiac intensive care units. On a paediatric cardiac intensive care unit, complex congenital cardiac conditions are com...
journal_title:Pediatric radiology
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abstract::Three children with neurofibromatosis involving the lower urinary tract are reported and their clinical, radiological and pathological findings are described. Lower urinary tract involvement in neurofibromatosis has previously been reported in 17 children, 12 of whom had other stigmata of von Recklinghausens disease. ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00975350
更新日期:1976-04-14 00:00:00
abstract::Rickets is characterized by impaired mineralization and ossification of the growth plates of growing children caused by a variety of disorders, the most frequent of which is nutritional deficiency of vitamin D. Despite ample knowledge of its etiology and the availability of cost-effective methods of preventing it, vit...
journal_title:Pediatric radiology
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doi:10.1007/s00247-012-2532-x
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abstract::malrotation and Hirschsprung's disease are common gastrointestinal abnormalities in neonates and infants. Four patients with the association of malrotation and Hirschsprung's disease are reported. A delay in diagnosis may be complicated by midgut volvulus or enterocolitis. The diagnostic and therapeutic implications o...
journal_title:Pediatric radiology
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doi:10.1007/BF01221703
更新日期:1982-01-01 00:00:00
abstract::Appropriate management of the child with malrotation and/or midgut volvulus requires a multi-disciplinary approach with early clinical suspicion, rapid confirmation of diagnosis, and expedient operative intervention in order to obtain the most effective outcomes. ...
journal_title:Pediatric radiology
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doi:10.1007/s00247-008-1129-x
更新日期:2009-04-01 00:00:00
abstract::Acute lymphoblastic leukemia (ALL) is the most common of all childhood malignancies. Current remission rates approach 80%. Recurrent disease can present in a wide variety of ways. MR imaging plays a crucial role in the detection of disease relapse. Because other disorders can mimic recurrence of leukemia, it is import...
journal_title:Pediatric radiology
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journal_title:Pediatric radiology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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更新日期:2018-05-01 00:00:00
abstract::Pulmonary capillary haemangiomatosis (PCH) is a rare disorder characterized by widespread capillary proliferation in the lung, infiltrating the interstitium and the alveolar walls. We present the HRCT features of PCH in a surviving ex-premature infant. To our knowledge, this is a unique case of the radiological featur...
journal_title:Pediatric radiology
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doi:10.1007/s00247-004-1374-6
更新日期:2005-06-01 00:00:00
abstract::In a period of 6 years 144 asymptomatic boys with cryptorchidism, of mean age 7 +/- SD 3.5 years, underwent orchiopexy. None of these boys referred to a history of a known urological anomaly, urinary tract infection, haematuria, palpable mass in the renal region, bladder extrophy, epispadias, hypospadias or anorectal ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02395760
更新日期:1988-01-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章,评审
doi:10.1007/s00247-008-1035-2
更新日期:2009-01-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00973989
更新日期:1977-03-17 00:00:00
abstract::We report a Japanese boy, who is considered as having Patterson-Lowry rhizomelic dysplasia, a rare, as yet undefined, skeletal dysplasia. The diagnosis was warranted by the constellation of skeletal abnormalities - mild platyspondyly, hypoplastic ilia, broad proximal femora with prominent lesser trochanters, mild brac...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/s002470000401
更新日期:2001-02-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02387500
更新日期:1986-01-01 00:00:00
abstract::A retrospective study was performed of the radiographic patterns of the lungs in children being followed in the Children's Hospital Aids Program (CHAP). The most consistent finding was a diffuse reticulonodular pattern in the lungs. In addition, lung consolidation, either isolated or in combination with nodules, was n...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02010931
更新日期:1993-01-01 00:00:00
abstract::A 9-year-old boy was referred to the Oncology Department because of a thoracic soft-tissue mass thought to be a chest wall tumour. He had a history of grass inflorescence (Hordeum murinum) aspiration 2 weeks prior to this admission. On physical examination a tender soft-tissue mass under the right scapula and diminish...
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pub_type: 杂志文章
doi:10.1007/s00247-005-0088-8
更新日期:2006-05-01 00:00:00
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doi:10.1007/s00247-007-0426-0
更新日期:2007-04-01 00:00:00
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journal_title:Pediatric radiology
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更新日期:1996-01-01 00:00:00
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更新日期:2009-11-01 00:00:00
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journal_title:Pediatric radiology
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更新日期:2014-10-01 00:00:00
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journal_title:Pediatric radiology
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doi:10.1007/s00247-001-0646-7
更新日期:2002-06-01 00:00:00
abstract::Pelvis-shoulder dysplasia is rare skeletal dysplasia characterised by symmetrical hypoplasia of the iliac wings and scapulae. It may be associated with unstable hips in infancy, a prominent lumbar lordosis and a waddling gait. Symptoms tend to lessen with increasing age. A child with this condition who has been follow...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF00972181
更新日期:1977-01-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02018618
更新日期:1991-01-01 00:00:00
abstract::Spontaneous reduction of a presumed ileo-colonic intussusception was demonstrated by ultrasound examination followed by a barium enema. No premedication or anesthetic had been given to the child. This case illustrates the possible natural history of intussusception rarely confirmed by imaging studies. Intussusception ...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02013178
更新日期:1990-01-01 00:00:00
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journal_title:Pediatric radiology
pub_type: 杂志文章
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journal_title:Pediatric radiology
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更新日期:1984-01-01 00:00:00
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更新日期:2008-06-01 00:00:00