Highly variable COI haplotype diversity between three species of invasive pest fruit fly reflects remarkably incongruent demographic histories.

abstract：:AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose metabolism. Here, we demonstrated that shizukaol F, a natural compound isolated from Chloranthus japonicus, can activate AMPK and modulate glucose metabolism both in vitro and in vivo. Shizukaol F increased glucose uptake in differentiated C2...

journal_title：Scientific reports

authors： Hu R,Yan H,Fei X,Liu H,Wu J

更新日期：2017-04-10 00:00:00

abstract：:Angiogenesis is essential in tumor biology and is regulated by vascular endothelial growth factor (VEGF) ligands and receptors. Here we aimed to discover genetic variants associated with levels of circulating angiogenic proteins in cancer patients. Plasma was collected at baseline in 216 pancreatic and 114 colorectal ...

journal_title：Scientific reports

authors： Innocenti F,Jiang C,Sibley AB,Etheridge AS,Hatch AJ,Denning S,Niedzwiecki D,Shterev ID,Lin J,Furukawa Y,Kubo M,Kindler HL,Auman JT,Venook AP,Hurwitz HI,McLeod HL,Ratain MJ,Gordan R,Nixon AB,Owzar K

更新日期：2018-11-05 00:00:00

abstract：:The molecular bases of the Frank-Starling law of the heart and of its cellular counterpart, the length dependent activation (LDA), are largely unknown. However, the recent discovery of the thick filament activation, a second pathway beside the well-known calcium mediated thin filament activation, is promising for eluc...

journal_title：Scientific reports

authors： Marcucci L,Washio T,Yanagida T

更新日期：2019-02-04 00:00:00

abstract：:Chinese hamster ovary (CHO) cells are mainly used for recombinant protein production. However, the unstable transgene expression and lower transgene copy numbers are the major issues need to be resolved. Here, eleven internal ribosome entry site (IRES) elements from viral and cellular IRES were evaluated for foreign g...

journal_title：Scientific reports

authors： Chai YR,Ge MM,Wei TT,Jia YL,Guo X,Wang TY

更新日期：2018-04-27 00:00:00

abstract：:A low-bandgap acceptor (ITIC) was added to a binary system composed of a wide-bandgap polymer (PBT-OTT) and an acceptor (PC71BM) to increase the light harvesting efficiency of the associated organic solar cells (OSCs). A ternary blend OSC with an acceptor ratio of PC71BM:ITIC = 8:2 was found to exhibit a power convers...

journal_title：Scientific reports

authors： Hwang H,Sin DH,Park C,Cho K

更新日期：2019-08-19 00:00:00

abstract：:The interplay between orbital, charge, spin, and lattice degrees of freedom is at the core of correlated oxides. This is extensively studied at the interface of heterostructures constituted of two-layer or multilayer oxide films. Here, we demonstrate the interactions between orbital reconstruction and charge transfer ...

journal_title：Scientific reports

authors： Cui B,Song C,Li F,Wang GY,Mao HJ,Peng JJ,Zeng F,Pan F

更新日期：2014-02-26 00:00:00

abstract：:In December 2015, four violent explosive episodes from Mt. Etna's oldest summit crater, the Voragine, produced eruptive columns extending up to 15 km a.s.l. and significant fallout of tephra up to a hundred km from the vent. A combined textural and compositional study was carried out on pyroclasts from three of the fo...

journal_title：Scientific reports

authors： Pompilio M,Bertagnini A,Del Carlo P,Di Roberto A

更新日期：2017-07-06 00:00:00

abstract：:The typical photodetectors can only detect one specific optical spectral band, such as InGaAs and graphene-PbS quantum dots for near-infrared (NIR) light detection, CdS and Si for visible light detection, and ZnO and III-nitrides for UV light detection. So far, none of the developed photodetector can achieve the multi...

journal_title：Scientific reports

authors： Sang L,Hu J,Zou R,Koide Y,Liao M

更新日期：2013-01-01 00:00:00

abstract：:Cleavage of the amyloid precursor protein's (APP) transmembrane domain (TMD) by γ-secretase is a crucial step in the aetiology of Alzheimer's Disease (AD). Mutations in the APP TMD alter cleavage and lead to familial forms of AD (FAD). The majority of FAD mutations shift the preference of initial cleavage from ε49 to ...

journal_title：Scientific reports

authors： Götz A,Högel P,Silber M,Chaitoglou I,Luy B,Muhle-Goll C,Scharnagl C,Langosch D

更新日期：2019-03-29 00:00:00

abstract：:Activation of cell cycle regulated transcription during the G1-to-S transition initiates S phase entry and cell cycle commitment. The molecular mechanisms involving G1/S transcriptional regulation are well established and have been shown to be evolutionary conserved from yeast to humans. Previous work has suggested th...

journal_title：Scientific reports

authors： Kishkevich A,Cooke SL,Harris MRA,de Bruin RAM

更新日期：2019-07-23 00:00:00

abstract：:Despite their interest and threat status, the number of whales in world's oceans remains highly uncertain. Whales detection is normally carried out from costly sighting surveys, acoustic surveys or through high-resolution images. Since deep convolutional neural networks (CNNs) are achieving great performance in severa...

journal_title：Scientific reports

authors： Guirado E,Tabik S,Rivas ML,Alcaraz-Segura D,Herrera F

更新日期：2019-10-03 00:00:00

abstract：:Deficits in GABAergic inhibitory neurotransmission are a reliable finding in schizophrenia (SCZ) patients. Previous studies have reported that unaffected first-degree relatives of patients with SCZ demonstrate neurophysiological abnormalities that are intermediate between probands and healthy controls. In this study, ...

journal_title：Scientific reports

authors： Radhu N,Dominguez LG,Greenwood TA,Farzan F,Semeralul MO,Richter MA,Kennedy JL,Blumberger DM,Chen R,Fitzgerald PB,Daskalakis ZJ

更新日期：2017-02-27 00:00:00

abstract：:Central visual field (CVF) loss has been linked to poorer vision-related quality of life in eyes with open-angle glaucoma (OAG) and can occur even in early-stage OAG eyes. The present study investigated whether the detection of choroidal microvasculature dropout (CMvD) during follow-up, which may be a sign of perfusio...

journal_title：Scientific reports

authors： Jo YH,Kwon J,Jeong D,Shon K,Kook MS

更新日期：2019-06-12 00:00:00

abstract：:Altered metabolism is considered as a hallmark of cancer. Here we investigated expression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) 2 lyase (HMGCL), an essential enzyme in ketogenesis, which produces ketone bodies by the breakdown of fatty acids to supply energy, in nasopharyngeal carcinoma (NPC). The express...

journal_title：Scientific reports

authors： Luo W,Qin L,Li B,Liao Z,Liang J,Xiao X,Xiao X,Mo Y,Huang G,Zhang Z,Zhou X,Li P

更新日期：2017-09-20 00:00:00

abstract：:Recent results have shown that participants can enumerate multiple parts of a single object as efficiently as multiple distinct objects, suggesting a shared mechanism for individuation of objects and object parts. Here we used the subitizing phenomenon to investigate the neural mechanism underlying the individuation o...

journal_title：Scientific reports

authors： Poncet M,Caramazza A,Mazza V

更新日期：2016-12-07 00:00:00

abstract：:Phytosterols found naturally in plants are known to reduce cholesterol absorption in the gut. The traditional southern Chinese diet typically contains many vegetables and not much meat, and there is high prevalence of lactose intolerance in Chinese; we therefore aimed to test if phytosterols-enriched milk is effective...

journal_title：Scientific reports

authors： Cheung CL,Ho DK,Sing CW,Tsoi MF,Cheng VK,Lee GK,Ho YN,Cheung BM

更新日期：2017-01-24 00:00:00

abstract：:Biofilm formation in flea gut is important for flea-borne transmission of Yersinia pestis. There are enhancing factors (HmsHFRS, HmsCDE, and HmsT) and inhibiting one (HmsP) for Yersinia pestis biofilm formation. The RcsAB regulatory complex acts as a repressor of Yesinia biofilm formation, and adaptive pseudogenizatio...

journal_title：Scientific reports

authors： Fang N,Yang H,Fang H,Liu L,Zhang Y,Wang L,Han Y,Zhou D,Yang R

更新日期：2015-04-01 00:00:00

abstract：:Due to the potentially detrimental consequences of low performance in basic functional tasks, individuals are expected to improve performance with age and show the most marked changes during early stages of life. Soaring-gliding birds use rising-air columns (thermals) to reduce energy expenditure allocated to flight. ...

journal_title：Scientific reports

authors： Harel R,Horvitz N,Nathan R

更新日期：2016-06-13 00:00:00

abstract：:Adverse maternal environments, such as diabetes and obesity, impair placental mitochondrial function, which affects fetal development and offspring long-term health. The underlying mechanisms and effective interventions to abrogate such effect remain unclear. Our previous studies demonstrated impaired mitochondrial bi...

journal_title：Scientific reports

authors： Jiang S,Teague AM,Tryggestad JB,Jensen ME,Chernausek SD

更新日期：2020-05-20 00:00:00

abstract：:CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to edit the genome. Reducing mosaic mutations is particularly important for gene therapy and precision genome editing. Although the mechanisms underlying the CRSIPR...

journal_title：Scientific reports

authors： Tu Z,Yang W,Yan S,Yin A,Gao J,Liu X,Zheng Y,Zheng J,Li Z,Yang S,Li S,Guo X,Li XJ

更新日期：2017-02-03 00:00:00

abstract：:Osteogenesis imperfecta (OI), a congenital bone disorder, is caused by mutations in COL1A1 and COL1A2 genes, leading to deficiency of type I collagen. The high resolution melting (HRM) analysis has been used for detecting mutations, polymorphisms and epigenetic alteration in double-stranded DNAs. This study was to eva...

journal_title：Scientific reports

authors： Wang J,Ren X,Bai X,Zhang T,Wang Y,Li K,Li G

更新日期：2015-08-26 00:00:00

abstract：:V2O5 based materials are attractive cathode alternatives due to the many oxidation state switches of vanadium bringing about a high theoretical specific capacity. However, significant capacity losses are eminent for crystalline V2O5 phases related to the irreversible phase transformations and/or vanadium dissolution s...

journal_title：Scientific reports

authors： Afyon S,Krumeich F,Mensing C,Borgschulte A,Nesper R

更新日期：2014-11-19 00:00:00

abstract：:The nucleotides guanosine tetraphosphate and pentaphosphate (together known as (p)ppGpp or magic spot) are produced in plant plastids from GDP/GTP and ATP by RelA-SpoT homologue (RSH) enzymes. In the model plant Arabidopsis (p)ppGpp regulates chloroplast transcription and translation to affect growth, and is also impl...

journal_title：Scientific reports

authors： Avilan L,Puppo C,Villain A,Bouveret E,Menand B,Field B,Gontero B

更新日期：2019-11-27 00:00:00

abstract：:Mechanical forces are critical to modulate cell spreading, contractility, gene expression, and even stem cell differentiation. Yet, existing tools that can apply controllable subcellular forces to a large number of single cells simultaneously are still limited. Here we report a novel ultrasound tweezing cytometry util...

journal_title：Scientific reports

authors： Fan Z,Sun Y,Di Chen,Tay D,Chen W,Deng CX,Fu J

更新日期：2013-01-01 00:00:00

abstract：:The nanosecond laser-induced damage growth phenomenon on the exit surface of fused silica grating is investigated at 1064 nm and 355 nm separately and also simultaneously. Experiments are first carried out on damage sites on a plane fused silica sample showing two different morphologies, and a damage type is selected ...

journal_title：Scientific reports

authors： Chambonneau M,Lamaignère L

更新日期：2018-01-17 00:00:00

abstract：:The subthalamic nucleus (STN) is the main target for neurosurgical treatment of motor signs of Parkinson's disease (PD). Despite the therapeutic effect on both upper and lower extremities, its role in motor control and coordination and its changes in Parkinson's disease are not fully clear. We intraoperatively recorde...

journal_title：Scientific reports

authors： Tankus A,Strauss I,Gurevich T,Mirelman A,Giladi N,Fried I,Hausdorff JM

更新日期：2017-02-13 00:00:00

abstract：:Habitat fragmentation can reduce population viability, especially for area-sensitive species. The Minimum Area Requirements (MAR) of a population is the area required for the population's long-term persistence. In this study, the response of occupancy probability of giant pandas against habitat patch size was studied ...

journal_title：Scientific reports

authors： Qing J,Yang Z,He K,Zhang Z,Gu X,Yang X,Zhang W,Yang B,Qi D,Dai Q

更新日期：2016-12-08 00:00:00

abstract：:The therapeutic effects of C16, which is an inhibitor of RNA-dependent protein kinase (PKR), on growth of hepatocellular carcinoma (HCC) cells and tumor progression in vitro and in vivo were evaluated. Huh7 cells, a human HCC cell line, were used. The effects of C16 on cell viability were evaluated with the MTT assay,...

journal_title：Scientific reports

authors： Watanabe T,Ninomiya H,Saitou T,Takanezawa S,Yamamoto S,Imai Y,Yoshida O,Kawakami R,Hirooka M,Abe M,Imamura T,Hiasa Y

更新日期：2020-03-20 00:00:00

abstract：:We construct two families of orthogonal product quantum states that cannot be exactly distinguished by local operation and classical communication (LOCC) in the quantum system of (2k+i) ⊗ (2l+j) (i, j ∈ {0, 1} and i ≥ j ) and (3k+i) ⊗ (3l+j) (i, j ∈ {0, 1, 2}). And we also give the tiling structure of these two famili...

journal_title：Scientific reports

authors： Zhang X,Tan X,Weng J,Li Y

更新日期：2016-07-05 00:00:00

abstract：:Breast cancer survivors display altered inflammatory responses to immune challenges relative to cancer-naive controls likely due to previous cancer treatments, stress associated with cancer, and/or tumor physiology. Proper inflammatory responses are necessary for adaptive sickness behaviors (e.g., fatigue, anorexia, a...

journal_title：Scientific reports

authors： Santos JC,Bever SR,Pereira-da-Silva G,Pyter LM

更新日期：2019-01-24 00:00:00