Abstract:
:AMP-activated protein kinase (AMPK) is a key sensor and regulator of glucose metabolism. Here, we demonstrated that shizukaol F, a natural compound isolated from Chloranthus japonicus, can activate AMPK and modulate glucose metabolism both in vitro and in vivo. Shizukaol F increased glucose uptake in differentiated C2C12 myotubes by stimulating glucose transporter-4 (GLUT-4) membraned translocation. Treatment of primary mouse hepatocytes with shizukaol F decreased the expression of phosphoenolpyruvate carboxykinase 2 (PEPCK), glucose-6-phosphatase (G6Pase) and suppressed hepatic gluconeogenesis. Meanwhile, a single oral dose of shizukaol F reduced gluconeogenesis in C57BL/6 J mice. Further studies indicated that shizukaol F modulates glucose metabolism mainly by AMPKa phosphorylation activity. In addition, we also found that shizukaol F depolarizes the mitochondrial membrane and inhibits respiratory complex I, which may result in AMPK activation. Our results highlight the potential value of shizukaol F as a possible treatment of metabolic syndrome.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hu R,Yan H,Fei X,Liu H,Wu Jdoi
10.1038/s41598-017-00925-ysubject
Has Abstractpub_date
2017-04-10 00:00:00pages
778issue
1issn
2045-2322pii
10.1038/s41598-017-00925-yjournal_volume
7pub_type
杂志文章abstract::Epsilon-Near-Zero materials exhibit a transition in the real part of the dielectric permittivity from positive to negative value as a function of wavelength. Here we study metal-dielectric layered metamaterials in the homogenised regime (each layer has strongly subwavelength thickness) with zero real part of the permi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27700
更新日期:2016-06-13 00:00:00
abstract::We investigate the refractive error after phacovitrectomy for rhegmatogenous retinal detachment (RRD; 100 eyes) and epiretinal membrane (ERM; 102 eyes). Axial lengths were measured by optical biometry in most patients. The main outcome measures were the refractive and absolute prediction errors. The overall mean refra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29553-w
更新日期:2018-07-27 00:00:00
abstract::Dysfunctional epicardial adipose tissue (EAT) secretome can influence the heart's stretch response. However, the molecular mechanisms are still poorly understood. The aim of this study was to clarify how dysfunctional EAT promotes maladaptive heart remodeling in cardiovascular disease (CVD) through ST2 production asso...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46676-w
更新日期:2019-07-17 00:00:00
abstract::Childhood obesity and early rapid growth increase the risk for type 2 diabetes. Such early overnutrition can be modeled in mice by reducing litter size. We investigated the effects of early overnutrition and increased dietary fat intake on β cell function in Swiss Webster mice. On a moderate-fat diet, early overnutrit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39177-3
更新日期:2019-03-06 00:00:00
abstract::In the epoch of the Anthropocene change, complexity, and uncertainty create a demand for new systems of water management and governance. One such management model that is rapidly gaining traction amongst both scholars and practitioners is the concept of water resilience. Although increasing attention has been paid to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62896-x
更新日期:2020-04-06 00:00:00
abstract::Scleroderma is a refractory autoimmune skin fibrotic disorder. Alterations of microRNAs in lesional skin could be a new approach to treating the disease. Here, we found that expression of miR-155 was up regulated in lesional skin tissue from patients with either systemic or localized scleroderma, and correlated with f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20314
更新日期:2016-02-01 00:00:00
abstract::Contest behaviour, and in particular the propensity to attack an unfamiliar conspecific, is influenced by an individual's aggressiveness, as well as by experience of winning and losing (so called 'winner-loser effects'). Individuals vary in aggressiveness and susceptibility to winner-loser effects but the relationship...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69664-x
更新日期:2020-08-07 00:00:00
abstract::Despite phages' ubiquitous presence and great importance in shaping microbial communities, little is known about the diversity of specific phages in different ecological niches. Here, we isolated, sequenced, and characterized 38 Escherichia coli-infecting phages (coliphages) from poultry faeces to gain a better unders...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72177-2
更新日期:2020-09-16 00:00:00
abstract::This study aimed to investigate whether single nucleotide polymorphisms (SNPs) of five NLR family genes (NOD1, NOD2, NLRP1, NLRP3 and CIITA) are associated with Behcet's disease (BD) in a Chinese Han population. The study was carried out in 950 BD patients and 1440 controls for 19 SNPs in the selected NLR genes. In th...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/srep20098
更新日期:2016-02-01 00:00:00
abstract::Plasmonic metamaterials have overcome fundamental limitations in conventional optics by their capability to engineer material resonances and dispersions at will, holding great promise for sensing applications. Recent demonstrations of metamaterial sensors, however, have mainly relied on their resonant nature for stron...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03545-8
更新日期:2017-06-09 00:00:00
abstract::We show that ATM kinase inhibition using AZ31 prior to 9 or 9.25 Gy total body irradiation (TBI) reduced median time to moribund in mice to 8 days. ATR kinase inhibition using AZD6738 prior to TBI did not reduce median time to moribund. The striking finding associated with ATM inhibition prior to TBI was increased cry...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41892
更新日期:2017-02-01 00:00:00
abstract::H. pylori-induced chronic inflammation is considered the most important cause of gastric cancer. The actual process how chronic inflammation triggers gastric carcinogenesis is still not clear. In this study, neutrophils and relative markers in gastric cancer development were examined with immunohistochemistry and fluo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29762
更新日期:2016-07-14 00:00:00
abstract::In recent years, the monolithic material has been developed increasingly in the high performance liquid phase field, and it could also be applied in the field of catalyst, as a monolithic catalyst carrier, since it has a large specific surface area, and could be customized based on the mould. The monolithic catalyst i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35021-2
更新日期:2018-11-09 00:00:00
abstract::Despite the development of crystal engineering, it remains a great challenge to predict the crystal structure even for the simplest molecules, and a clear link between molecular and crystal symmetry is missing in general. Here we demonstrate that the two-dimensional (2D) crystallization of heterocirculenes on a Au(111...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05415
更新日期:2014-06-24 00:00:00
abstract::Pressure therapy has been proved to be an effective treatment for hypertrophic scars in a clinical setting. However, evidence-based data are controversial and the precise mechanism of action of this technique remains unknown. The aim of this study was to investigate the potential molecular mechanisms of pressure thera...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29840-6
更新日期:2018-08-07 00:00:00
abstract::Coronaviruses may exert severely negative effects on the mortality and morbidity of birds and mammals including humans and domestic animals. Most recently CoVID-19 has killed about half million people (27th of June, 2020). Susceptibility to this disease appears to differ markedly across different societies but the fac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69351-x
更新日期:2020-07-27 00:00:00
abstract::Motion sensitivity impairment in Alzheimer's disease (AD) is often characterized as elevated coherence threshold. An alternative way to measure motion sensitivity is the direction threshold, i.e., the minimal angle of motion direction that can be discriminated. So far, it is less clear whether and how the direction th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48942-3
更新日期:2019-09-10 00:00:00
abstract::Zebrafish is a popular and favorable model organism for cardiovascular research, with an increasing number of studies implementing functional assays in the adult stage. For example, the application of electrocardiography (ECG) in adult zebrafish has emerged as an important tool for cardiac pathophysiology, toxicity, a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33577-7
更新日期:2018-10-30 00:00:00
abstract::The close proximity of esophagus to the left atrial posterior wall predisposes esophagus to thermal injury during catheter ablation for atrial fibrillation (AF). In this retrospective study, we aimed to investigate risk factors of esophageal injury (EI) caused by catheter ablation for AF. Patients who underwent first-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59539-6
更新日期:2020-02-17 00:00:00
abstract::Micro-tube experiment has been implemented to understand the mechanisms of governing microcosmic fluid percolation and is extensively used in both fields of micro electromechanical engineering and petroleum engineering. The measured pressure difference across the microtube is not equal to the actual pressure differenc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16870-9
更新日期:2017-11-29 00:00:00
abstract::The spread of multidrug-resistant Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA), has shortened the useful life of anti-staphylococcal drugs enormously. Two approaches can be followed to address this problem: screening various sources for new leads for antibiotics or finding ways to di...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03716-7
更新日期:2017-06-19 00:00:00
abstract::Practical application of superhydrophobic surfaces is limited by the fragility of nanoscale asperities. Combining chemical etching and anodization, microscale pits and nanoscale pores, instead of the micro and nano protrusions on traditional superhydrophobic surfaces mimicking Lutos leaves, were fabricated on commerci...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20933
更新日期:2016-02-08 00:00:00
abstract::The pollination syndrome concept has provided powerful utility in understanding the evolution and adaptation of floral traits. However, the utility of this conception has been questioned on the grounds that flowers usually attract a broader spectrum of visitors than one might expect. Furthermore, the relationship betw...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70954-7
更新日期:2020-08-18 00:00:00
abstract::Nitrogen fixation is essential for the synthesis of many important chemicals (e.g., fertilizers, explosives) and basic building blocks for all forms of life (e.g., nucleotides for DNA and RNA, amino acids for proteins). However, direct nitrogen fixation is challenging as nitrogen (N₂) does not easily react with other ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02260
更新日期:2013-01-01 00:00:00
abstract::The regeneration of WPAC through pyrolysis and its adsorption capacity of phosphorus were studied. The optimum conditions for WPAC regeneration were 650 °C and 2 h which resulted in a recovery of BET surface and total pore volume with a value of 1161.4 m2/g and 1.2176 m3/g. WPAC had a maximum PO43--P adsorption capaci...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-19131-x
更新日期:2018-01-15 00:00:00
abstract::An accurate and efficient solution of the radiative transport equation is proposed for modeling the propagation of photons in the three-dimensional anisotropically scattering half-space medium. The exact refractive index mismatched boundary condition is considered and arbitrary rotationally invariant scattering functi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02018
更新日期:2013-01-01 00:00:00
abstract::To assess extraspinal findings (ESFs) prevalence in lumbar spine MRI, including clinically significant findings using a systematic approach, and to determine their reporting rate. Lumbar spine MRI scans were retrospectively reviewed over 18 months by two radiologists. Reading discrepancies were resolved by consensus. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81069-y
更新日期:2021-01-13 00:00:00
abstract::Tyrosine hydroxylase (TH), the initial enzyme in the melanin pathway, catalyzes tyrosine conversion into Dopa. Although expression and regulation of TH have been shown to affect cuticle pigmentation in insects, no direct functional studies to date have focused on the specific physiological processes involving the enzy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29835
更新日期:2016-07-15 00:00:00
abstract::Ganoderma lucidum polysaccharide peptide (GLPP) scavenges oxygen free radicals that are a key factor in the pathogenesis of renal ischemia reperfusion injury (RIRI). The aim of this study was to determine whether GLPP could attenuate RIRI by counteracting the oxidative stress. The mechanism involved was assessed by an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16910
更新日期:2015-11-25 00:00:00
abstract::Behavioral alterations emerging after central or peripheral vision loss suggest that cerebral reorganization occurs for both the afferented and deafferented early visual cortex (EVC). We explored the functional reorganization of the central and peripheral EVC following visual field defects specifically affecting centr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43223
更新日期:2017-02-24 00:00:00