A Comparative Analysis of CD32A and CD16A Polymorphisms in Relation to Autoimmune Responses in Pemphigus Diseases and Subepithelial Autoimmune Blistering Disorders.

abstract：:Dicentric chromosomes are a relevant marker of chromosomal instability. Their appearance is associated with telomere dysfunction, leading to cancer progression and a poor clinical outcome. Here, we present Telomere and Centromere staining followed by M-FISH (TC+M-FISH) for improved detection of telomere dysfunction an...

journal_title：Genes

authors： M'kacher R,Colicchio B,Borie C,Junker S,Marquet V,Heidingsfelder L,Soehnlen K,Najar W,Hempel WM,Oudrhiri N,Wilhelm-Murer N,Miguet M,Arnoux M,Ferrapie C,Kerbrat W,Plesch A,Dieterlen A,Girinsky T,Voisin P,Deschenes G

更新日期：2020-04-27 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is a cancer predisposition syndrome that results from dominant loss-of-function mutations mainly in the NF1 gene. Large rearrangements are present in 5-10% of affected patients, generally encompass NF1 neighboring genes, and are correlated with a more severe NF1 phenotype. Evident genoty...

journal_title：Genes

authors： Brussa Reis L,Turchetto-Zolet AC,Fonini M,Ashton-Prolla P,Rosset C

更新日期：2019-10-24 00:00:00

abstract：:Maize kernel development is a complex biological process that involves the temporal and spatial expression of many genes and fine gene regulation at a transcriptional and post-transcriptional level, and microRNAs (miRNAs) play vital roles during this process. To gain insight into miRNA-mediated regulation of maize ker...

journal_title：Genes

authors： Xing L,Zhu M,Zhang M,Li W,Jiang H,Zou J,Wang L,Xu M

更新日期：2017-12-14 00:00:00

abstract：:Histone modifications are important in regulating gene expression in eukaryotes. Of the numerous histone modifications which have been identified, acetylation is one of the best characterised and is generally associated with active genes. Histone acetylation can directly affect chromatin structure by neutralising char...

journal_title：Genes

authors： Josling GA,Selvarajah SA,Petter M,Duffy MF

更新日期：2012-05-29 00:00:00

abstract：:Transfer RNAs (tRNAs) are abundant small non-coding RNAs that are crucially important for decoding genetic information. Besides fulfilling canonical roles as adaptor molecules during protein synthesis, tRNAs are also the source of a heterogeneous class of small RNAs, tRNA-derived small RNAs (tsRNAs). Occurrence and th...

journal_title：Genes

authors： Oberbauer V,Schaefer MR

更新日期：2018-12-05 00:00:00

abstract：:The performance of genomic prediction (GP) on genetically correlated traits can be improved through an interdependence multi-trait model under a multi-environment context. In this study, a panel of 237 soft facultative wheat (Triticumaestivum L.) lines was evaluated to compare single- and multi-trait models for predic...

journal_title：Genes

authors： Guo J,Khan J,Pradhan S,Shahi D,Khan N,Avci M,Mcbreen J,Harrison S,Brown-Guedira G,Murphy JP,Johnson J,Mergoum M,Esten Mason R,Ibrahim AMH,Sutton R,Griffey C,Babar MA

更新日期：2020-10-28 00:00:00

abstract：:DNA methylation is an essential part of the epigenome chromatin modification network, which also comprises several covalent histone protein post-translational modifications. All these modifications are highly interconnected, because the writers and erasers of one mark, DNA methyltransferases (DNMTs) and ten eleven tra...

journal_title：Genes

authors： Jeltsch A,Broche J,Bashtrykov P

更新日期：2018-11-21 00:00:00

abstract：:Cyclocarya paliurus (Batal.) Iljinskaja, a unique species growing in southern China, is a multi-function tree species with medicinal, healthcare, material, and ornamental values. So far, sexual reproduction is the main method for extensive cultivation of C. paliurus plantations, but this is limited by low seed plumpne...

journal_title：Genes

authors： Chen X,Mao X,Huang P,Fang S

更新日期：2019-10-17 00:00:00

abstract：:Rapeseed contains glucosinolates, a toxic group of sulfur-containing glucosides, which play critical roles in defense against herbivores and microbes. However, the presence of glucosinolates in rapeseed reduces the value of the meal as feed for livestock. We performed association mapping of seed glucosinolate (GS) con...

journal_title：Genes

authors： Qu CM,Li SM,Duan XJ,Fan JH,Jia LD,Zhao HY,Lu K,Li JN,Xu XF,Wang R

更新日期：2015-11-18 00:00:00

abstract：:During CRISPR/Cas9 mediated genome editing, site-specific double strand breaks are introduced and repaired either unspecific by non-homologous end joining (NHEJ) or sequence dependent by homology directed repair (HDR). Whereas NHEJ-based generation of gene knock-out is widely performed, the HDR-based knock-in of speci...

journal_title：Genes

authors： Gerlach M,Kraft T,Brenner B,Petersen B,Niemann H,Montag J

更新日期：2018-06-13 00:00:00

abstract：:Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from "closed" to ...

journal_title：Genes

authors： Boeger H,Shelansky R,Patel H,Brown CR

更新日期：2015-06-30 00:00:00

abstract：:Despite the extensive research conducted in recent decades, the molecular mechanisms underlying major depressive disorder (MDD) and relative evidence-based treatments remain unclear. Various hypotheses have been successively proposed, involving different biological systems. This narrative review aims to critically ill...

journal_title：Genes

authors： Maffioletti E,Minelli A,Tardito D,Gennarelli M

更新日期：2020-09-18 00:00:00

abstract：:Interleukin 8 (IL-8) participates in the immune response and has the function of inducing neutrophils to release lysosomal enzymes and eliminate pathogens. This study was to investigate the effect of single nucleotide mutations in the IL-8 gene promoter region on the coccidiosis resistance index. In this study, 180 in...

journal_title：Genes

authors： Wang XH,Yu HL,Zou WB,Mi CH,Dai GJ,Zhang T,Zhang GX,Xie KZ,Wang JY

更新日期：2020-04-27 00:00:00

abstract：:Mgaloblishvili, a Vitis vinifera cultivar, exhibits unique resistance traits against Plasmopara viticola, the downy mildew agent. This offers the unique opportunity of exploring the molecular responses in compatible and incompatible plant-pathogen interaction. In this study, whole transcriptomes of Mgaloblishvili, Pin...

journal_title：Genes

authors： Toffolatti SL,De Lorenzis G,Brilli M,Moser M,Shariati V,Tavakol E,Maddalena G,Passera A,Casati P,Pindo M,Cestaro A,Maghradze D,Failla O,Bianco PA,Quaglino F

更新日期：2020-02-28 00:00:00

abstract：:Vitellogenin receptors (VgRs) play critical roles in egg formation by transporting vitellogenin (Vg) into oocytes in insects. Although the function of VgR in insects is well studied, the transcriptional regulation of this gene is still unclear. Here, we cloned the promoter of the VgR gene from Bombyx mori (BmVgR), and...

journal_title：Genes

authors： Shen G,Chen E,Ji X,Liu L,Liu J,Hua X,Li D,Xiao Y,Xia Q

更新日期：2020-04-06 00:00:00

abstract：:Single-cell RNA sequencing (scRNA-seq) has recently brought new insight into cell differentiation processes and functional variation in cell subtypes from homogeneous cell populations. A lack of prior knowledge makes unsupervised machine learning methods, such as clustering, suitable for analyzing scRNA-seq . However,...

journal_title：Genes

authors： Zhu X,Li HD,Xu Y,Guo L,Wu FX,Duan G,Wang J

更新日期：2019-01-29 00:00:00

abstract：:Since ancient times, the importance of physical activity (PA) and of a wholesome diet for human health has been clearly recognized. However, only recently, it has been acknowledged that PA can reverse at least some of the unwanted effects of a sedentary lifestyle, contributing to the treatment of pathologies such as h...

journal_title：Genes

authors： Di Liegro I

更新日期：2019-12-16 00:00:00

abstract：:Supernumerary B chromosomes (Bs) are dispensable genetic elements found in thousands of species of plants and animals, and some fungi [...]. ...

journal_title：Genes

authors： Houben A,Jones N,Martins C,Trifonov V

更新日期：2019-02-20 00:00:00

abstract：:Quorum sensing (QS) is a cell-to-cell communication system that uses autoinducers as signaling molecules to enable inter-species and intra-species interactions in response to external stimuli according to the population density. QS allows bacteria such as Acinetobacter baumannii to react rapidly in response to environ...

journal_title：Genes

authors： Ng CK,How KY,Tee KK,Chan KG

更新日期：2019-04-08 00:00:00

abstract：:Due to its extraordinary longevity and wide distribution, the ocean quahog Arctica islandica has become an important species model in both aging and environmental change research. Notwithstanding that, most genetic studies on ocean quahogs have been focused on fishery related, phylogeographic and phylogenetic aspects ...

journal_title：Genes

authors： García-Souto D,Pasantes JJ

更新日期：2018-06-13 00:00:00

abstract：:Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alte...

journal_title：Genes

authors： Salmoiraghi S,Cavagna R,Guinea Montalvo ML,Ubiali G,Tosi M,Peruta B,Intermesoli T,Oldani E,Salvi A,Pavoni C,Giussani U,Bassan R,Rambaldi A,Spinelli O

更新日期：2020-08-20 00:00:00

abstract：:DNA damage leads to genome instability by interfering with DNA replication. Cells possess several damage bypass pathways that mitigate the effects of DNA damage during replication. These pathways include translesion synthesis and template switching. These pathways are regulated largely through post-translational modif...

journal_title：Genes

authors： Ripley BM,Gildenberg MS,Washington MT

更新日期：2020-01-29 00:00:00

abstract：:Death investigations often include an effort to establish the postmortem interval (PMI) in cases in which the time of death is uncertain. The postmortem interval can lead to the identification of the deceased and the validation of witness statements and suspect alibis. Recent research has demonstrated that microbes pr...

journal_title：Genes

authors： Belk A,Xu ZZ,Carter DO,Lynne A,Bucheli S,Knight R,Metcalf JL

更新日期：2018-02-16 00:00:00

abstract：:Intercellular karyotypic variability has been a focus of genetic research for more than 50 years. It has been repeatedly shown that chromosome heterogeneity manifesting as chromosomal mosaicism is associated with a variety of human diseases. Due to the ability of changing dynamically throughout the ontogeny, chromosom...

journal_title：Genes

authors： Iourov IY,Vorsanova SG,Yurov YB,Kutsev SI

更新日期：2019-05-19 00:00:00

abstract：:Marek's Disease is a lymphoproliferative disease of chickens caused by Marek's Disease Virus. Similar to other herpesviruses, Marek's Disease Virus (MDV) encodes its own small non-coding regulatory RNAs termed microRNAs (miRNAs). We previously found that the expression profile of these viral miRNAs is affected by vacc...

journal_title：Genes

authors： Hicks JA,Liu HC

更新日期：2019-02-05 00:00:00

abstract：:Bupleurum falcatum, which belongs to the family Apiaceae, has long been applied for curative treatments, especially as a liver tonic, in herbal medicine. The chloroplast (cp) genome has been an ideal model to perform the evolutionary and comparative studies because of its highly conserved features and simple structure...

journal_title：Genes

authors： Shin DH,Lee JH,Kang SH,Ahn BO,Kim CK

更新日期：2016-05-13 00:00:00

abstract：:In this work, we have shown that Novosphingobium tardaugens NBRC 16725 (strain ARI-1), a bacterial strain that was isolated due to its capacity to mineralize the estrogenic endocrine compound 17β-estradiol, is also able to mineralize testosterone, the androgenic endocrine compound. Using in silico analysis, we predict...

journal_title：Genes

authors： Ibero J,Galán B,Díaz E,García JL

更新日期：2019-10-31 00:00:00

abstract：:Hemp is a Pb-tolerant and Pb-accumulating plant and the study of its tolerance mechanisms could facilitate the breeding of hemp with enhanced Pb tolerance and accumulation. In the present study, we took advantage of sequential window acquisition of all theoretical mass spectra (SWATH) technology to study the differenc...

journal_title：Genes

authors： Xia C,Hong L,Yang Y,Yanping X,Xing H,Gang D

更新日期：2019-05-22 00:00:00

abstract：:Magnaportheoryzae is a devastating plant pathogen, which has a detrimental impact on rice production worldwide. Despite its agronomical importance, some newly-emerging pathotypes often overcome race-specific disease resistance rapidly. It is thus desirable to develop a novel strategy for the long-lasting resistance of...

journal_title：Genes

authors： Zhu L,Zhu J,Liu Z,Wang Z,Zhou C,Wang H

更新日期：2017-09-26 00:00:00

abstract：:Background: Congenital disorder of glycosylation (CDG) is a severe morphogenic and metabolic disorder that affects all of the systems of organs and is caused by a mutation of the gene PMM2, having a mortality rate of 20% during the first months of life. Results: Here we report the outcome of an in vitro fertilisation ...

journal_title：Genes

authors： Doroftei B,Nemtanu L,Ilie OD,Simionescu G,Ivanov I,Anton E,Puiu M,Maftei R

更新日期：2020-06-25 00:00:00