Mdm2 enhances ligase activity of parkin and facilitates mitophagy.

abstract：:Plants would experience more complex environments, such as sudden heat shock (SHS) stress combined with elevated CO2 in the future, and might adapt to this stressful condition by optimizing photosynthetic carbon metabolism (PCM). It is interesting to understand whether this acclimation process would be altered in diff...

journal_title：Scientific reports

authors： Qu M,Chen G,Bunce JA,Zhu X,Sicher RC

更新日期：2018-05-18 00:00:00

abstract：:Recent studies suggest that glypican-1 (GPC-1) is a biomarker for prostate cancer, but there are few studies elucidating the role of GPC-1 in prostate cancer progression. We observed high expression of GPC-1 in more aggressive prostate cancer cell lines such as PC-3 and DU-145. While inhibition of GPC-1 expression in ...

journal_title：Scientific reports

authors： Quach ND,Kaur SP,Eggert MW,Ingram L,Ghosh D,Sheth S,Nagy T,Dawson MR,Arnold RD,Cummings BS

更新日期：2019-08-07 00:00:00

abstract：:We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were perfor...

journal_title：Scientific reports

authors： Katagiri S,Nishina S,Yokoi T,Mikami M,Nakayama Y,Tanaka M,Azuma N

更新日期：2017-02-16 00:00:00

abstract：:Synthesis of homogenous glycans in quantitative yields represents a major bottleneck to the production of molecular tools for glycoscience, such as glycan microarrays, affinity resins, and reference standards. Here, we describe a combined biological/enzymatic synthesis that is capable of efficiently converting microbi...

journal_title：Scientific reports

authors： Hamilton BS,Wilson JD,Shumakovich MA,Fisher AC,Brooks JC,Pontes A,Naran R,Heiss C,Gao C,Kardish R,Heimburg-Molinaro J,Azadi P,Cummings RD,Merritt JH,DeLisa MP

更新日期：2017-11-21 00:00:00

abstract：:Incomplete or partial observations of network structures pose a serious challenge to theoretical and engineering studies of real networks. To remedy the missing links in real datasets, topology-based link prediction is introduced into the studies of various networks. Due to the complexity of network structures, the ac...

journal_title：Scientific reports

authors： Cao Z,Zhang Y,Guan J,Zhou S

更新日期：2018-09-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Taheri S,Abdullah TL,Rafii MY,Harikrishna JA,Werbrouck SPO,Teo CH,Sahebi M,Azizi P

更新日期：2019-11-05 00:00:00

abstract：:Two-dimensional (2D) gold nanoparticles can possess novel physical and chemical properties, which will greatly expand the utility of gold nanoparticles in a wide variety of applications ranging from catalysis to biomedicine. However, colloidal synthesis of such particles generally requires sophisticated synthetic tech...

journal_title：Scientific reports

authors： Shin Y,Lee C,Yang MS,Jeong S,Kim D,Kang T

更新日期：2014-08-26 00:00:00

abstract：:Treatment as Prevention (TasP) using directly-acting antivirals has been advocated for Hepatitis C Virus (HCV) in people who inject drugs (PWID), but treatment is expensive and TasP's effectiveness is uncertain. Previous modelling has assumed a homogeneously-mixed population or a static network lacking turnover in the...

journal_title：Scientific reports

authors： Metzig C,Surey J,Francis M,Conneely J,Abubakar I,White PJ

更新日期：2017-05-12 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Lee DB,Kim JM,Seok JH,Lee JH,Jo JD,Mun JY,Conrad C,Coe J,Nelson G,Hogue B,White TA,Zatsepin N,Weierstall U,Barty A,Chapman H,Fromme P,Spence J,Chung MS,Oh CH,Kim KH

更新日期：2018-04-17 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinases ErbB family and it is found to be overexpressed in gastric cancer. However, the mechanism of the regulation of the EGFR expression is still unknown. We used the Sequenom EpiTYPER assay to detect the methylation status of the EGFR prom...

journal_title：Scientific reports

authors： Weng X,Zhang H,Ye J,Kan M,Liu F,Wang T,Deng J,Tan Y,He L,Liu Y

更新日期：2015-05-11 00:00:00

abstract：:One mechanism of action for the anticaries effect of topical fluoridation is through precipitation of CaF2. In this in vitro study energy-dispersive x-ray spectroscopy (EDX) is used as a semiquantitative method to detect enamel fluoride-precipitation under the influence of acidic and neutral pH-value and absence or pr...

journal_title：Scientific reports

authors： Scholz KJ,Federlin M,Hiller KA,Ebensberger H,Ferstl G,Buchalla W

更新日期：2019-09-17 00:00:00

abstract：:The present study investigated the treatment and survival outcomes of patients with synchronous primary esophageal squamous cell carcinoma and gastric adenocarcinoma. The medical records of 10,783 patients with primary esophageal squamous cancer treated at our institution between 1995 and 2012 were retrospectively rev...

journal_title：Scientific reports

authors： Li X,Lin S,Zhang Y,Wang H

更新日期：2015-08-20 00:00:00

abstract：:We characterized an anti-cancer fusion protein consisting of anthrax lethal factor (LF) and the catalytic domain of Pseudomonas exotoxin A by (i) mutating the N-terminal amino acids and by (ii) reductive methylation to dimethylate all lysines. Dimethylation of lysines was achieved quantitatively and specifically witho...

journal_title：Scientific reports

authors： Bachran C,Gupta PK,Bachran S,Leysath CE,Hoover B,Fattah RJ,Leppla SH

更新日期：2014-04-23 00:00:00

abstract：:This multi-institutional study sought to clarify the association between the preoperative serum albumin/globulin ratio (AGR) and the prognosis of renal cell carcinoma (RCC) in a large cohort. This study encompassed eight institutions and 2,970 non-metastatic RCC patients who underwent a radical or partial nephrectomy ...

journal_title：Scientific reports

authors： Chung JW,Park DJ,Chun SY,Choi SH,Lee JN,Kim BS,Kim HT,Kim TH,Yoo ES,Byun SS,Hwang EC,Kang SH,Hong SH,Chung J,Kwak C,Kim YJ,Ha YS,Kwon TG

更新日期：2020-07-20 00:00:00

abstract：:Meishan boars are known for their early sexual maturity. However, they exhibit a significantly smaller testicular size and a reduced proportion of Sertoli cells and daily sperm production compared with Duroc boars. The testes of Duroc and Meishan boars at 20, 75 and 270 days of age were used for histological and trans...

journal_title：Scientific reports

authors： Ding H,Luo Y,Liu M,Huang J,Xu D

更新日期：2016-02-11 00:00:00

abstract：:This study aimed to explore the effects of radiochemotherapy on the neurocognitive function of patients with high-grade gliomas (HGG). The mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA), event-related potential P300 (ERP-P300), and specific MRI parameters were compared, and the associations...

journal_title：Scientific reports

authors： Bian Y,Meng L,Peng J,Li J,Wei R,Huo L,Yang H,Wang Y,Fu J,Shen L,Hong J

更新日期：2019-04-12 00:00:00

abstract：:In this study, the influence of intratumoral morphological heterogeneity of breast cancer on neoadjuvant chemotherapy (NAC) efficiency was investigated. In particular, we analysed the association of NAC response and pre- and post-NAC expression of the main multidrug resistance (MDR) genes--ABCB1, ABCC1, ABCC5, ABCG1, ...

journal_title：Scientific reports

authors： Denisov EV,Litviakov NV,Zavyalova MV,Perelmuter VM,Vtorushin SV,Tsyganov MM,Gerashchenko TS,Garbukov EY,Slonimskaya EM,Cherdyntseva NV

更新日期：2014-04-16 00:00:00

abstract：:A novel and simple method to fabricate microchannels is reported based on an inkjet printing of a volatile solid mold. A liquid ink -1,6 hexanediol- ejected from a piezoelectric nozzle is instantaneously frozen when touching a cooled substrate. The created mold is then poured with PDMS. Once the PDMS is crosslinked, t...

journal_title：Scientific reports

authors： Brossard R,Brouchet T,Malloggi F

更新日期：2019-11-25 00:00:00

abstract：:Few-layer black phosphorus (BP) is the most promising material among the two-dimensional materials due to its layered structure and the excellent semiconductor properties. Currently, thin BP atomic layers are obtained mostly by mechanical exfoliation of bulk BP, which limits applications in thin-film based electronics...

journal_title：Scientific reports

authors： Seo S,Lee HU,Lee SC,Kim Y,Kim H,Bang J,Won J,Kim Y,Park B,Lee J

更新日期：2016-03-30 00:00:00

abstract：:Evaluation of facial asymmetry generally involves landmark-based analyses that cannot intuitively assess differences in three-dimensional (3D) stereoscopic structures between deviation and non-deviation sides. This study tested a newly developed similarity index that uses a mirroring technique to intuitively evaluate ...

journal_title：Scientific reports

authors： Kwon SM,Hwang JJ,Jung YH,Cho BH,Lee KJ,Hwang CJ,Choi SH

更新日期：2019-07-29 00:00:00

abstract：:An early bottleneck in the rapid isolation of new antibody fragment binders using in vitro library approaches is the inertia encountered in acquiring and preparing soluble antigen fragments. In this report, we describe a simple, yet powerful strategy that exploits the properties of the SpyCatcher/SpyTag (SpyC/SpyT) co...

journal_title：Scientific reports

authors： Fierle JK,Abram-Saliba J,Brioschi M,deTiani M,Coukos G,Dunn SM

更新日期：2019-09-06 00:00:00

abstract：:New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A panel of compounds with two carboxylate groups as phosphates bioisosteres, was synthesized with the same glucosamine-bis-succinyl core linked to different unsaturated and saturated fatty acid chains. The binding of the ...

journal_title：Scientific reports

authors： Cochet F,Facchini FA,Zaffaroni L,Billod JM,Coelho H,Holgado A,Braun H,Beyaert R,Jerala R,Jimenez-Barbero J,Martin-Santamaria S,Peri F

更新日期：2019-01-29 00:00:00

abstract：:In honeybees fast and efficient exploitation of nectar and pollen sources is achieved by persistent endothermy throughout the foraging cycle, which means extremely high energy costs. The need for food promotes maximisation of the intake rate, and the high costs call for energetic optimisation. Experiments on how honey...

journal_title：Scientific reports

authors： Stabentheiner A,Kovac H

更新日期：2016-06-20 00:00:00

abstract：:The ability to perform not only elementally but also isotopically sensitive detection and analysis at standoff distances is impor-tant for remote sensing applications in diverse ares, such as nuclear nonproliferation, environmental monitoring, geophysics, and planetary science. We demonstrate isotopically sensitive re...

journal_title：Scientific reports

authors： Hartig KC,Ghebregziabher I,Jovanovic I

更新日期：2017-03-08 00:00:00

abstract：:Tissue adhesion is a common complication after surgery. In this work, a dexamethasone loaded polymeric micelles in thermosensitive hydrogel composite (Dex hydrogel) was prepared, which combined the anti-adhesion barrier with controlled release of anti-adhesion drug. Dexamethasone (Dex) was encapsulated in polymeric mi...

journal_title：Scientific reports

authors： Wu Q,Wang N,He T,Shang J,Li L,Song L,Yang X,Li X,Luo N,Zhang W,Gong C

更新日期：2015-09-01 00:00:00

abstract：:Orexins are originally characterized as orexigenic hypothalamic neuropeptides in mammals. Subsequent studies found orexin to be expressed and perform pleiotropic functions in multiple tissues in mammals. In avian (non-mammalian) species, however, orexin seemed to not affect feeding behavior and its physiological roles...

journal_title：Scientific reports

authors： Greene ES,Zampiga M,Sirri F,Ohkubo T,Dridi S

更新日期：2020-11-05 00:00:00

abstract：:KaiC, the core oscillator of the cyanobacterial circadian clock, is composed of an N-terminal C1 domain and a C-terminal C2 domain, and assembles into a double-ring hexamer upon ATP binding. Cyclic phosphorylation and dephosphorylation at Ser431 and Thr432 in the C2 domain proceed with a period of approximately 24 h i...

journal_title：Scientific reports

authors： Mukaiyama A,Furuike Y,Abe J,Koda SI,Yamashita E,Kondo T,Akiyama S

更新日期：2018-06-11 00:00:00

abstract：:To examine patterns of human immunodeficiency virus (HIV) cause-specific deaths, risk factors, and the effect of interactions on mortality, we conducted a retrospective cohort study in Zhejiang, China, from 2006 to 2013. All data were downloaded from the acquired immune deficiency syndrome (AIDS) Prevention and Contro...

journal_title：Scientific reports

authors： Chen L,Pan X,Ma Q,Yang J,Xu Y,Zheng J,Wang H,Zhou X,Jiang T,Jiang J,He L,Jiang J

更新日期：2017-02-15 00:00:00

abstract：:We propose an ultrathin metallic structure to produce frequency-selective spoof surface plasmon polaritons (SPPs) in the microwave and terahertz frequencies. Designed on a thin dielectric substrate, the ultrathin metallic structure is composed of two oppositely oriented single-side corrugated strips, which are coupled...

journal_title：Scientific reports

authors： Yin JY,Ren J,Zhang HC,Pan BC,Cui TJ

更新日期：2015-02-02 00:00:00

abstract：:Purpose Global sagittal imbalance with lumbar hypo-lordosis leads to various problems in elderly populations and is often treated with long-segment fusion and osteotomy. These highly invasive procedures result in a wide range of rigid spines with a high rate of complications. Although some reports have mentioned the p...

journal_title：Scientific reports

authors： Inanami H,Iwai H,Kaneko T,Oshina M,Manabe N,Takano Y,Yuzawa Y,Segawa T,Yanagisawa K,Hirai S,Saiki F,Fukushima M,Oka H,Matsudaira K,Oshima Y,Koga H

更新日期：2020-04-21 00:00:00