Abstract：
:Abelmoschus manihot (Linn.) is a medicinal herbal plant that is commonly used to treat chronic kidney disease and hepatitis. However, its effect on cell proliferation has not been clearly revealed. In this report, we sought to determine the effect of the flower extract of A. manihot (FA) on cell proliferation. Based on our findings, FA increased the proliferation of human diploid fibroblast (HDF) and HEK293 cells. Through cell cycle analysis, FA was found to increase the number of HDF cells in the S phase and G2/M phase. FA also increased the expression of cyclin D1 and enhanced the migration of HDF cells. By administering FA to HDF cells with ≥30 passages, a decrease in the number of senescence-associated β galactosidase-positive cells was observed, thereby indicating that FA can ameliorate cellular senescence. Collectively, our findings indicate that FA increases cyclin D1 expression and regulates cell proliferation.
journal_name
J Microbiol Biotechnoljournal_title
Journal of microbiology and biotechnologyauthors
Park YI,Cha YE,Jang M,Park R,Namkoong S,Kwak J,Jang IS,Park Jdoi
10.4014/jmb.2002.02024subject
Has Abstractpub_date
2020-07-28 00:00:00pages
1044-1050issue
7eissn
1017-7825issn
1738-8872pii
10.4014/jmb.2002.02024journal_volume
30pub_type
杂志文章abstract：:An endocellulase-free multienzyme complex was produced by a thermophilic anaerobic bacterium, Thermoanaerobacterium thermosaccharolyticum strain NOI-1, when grown on xylan. The temperature and pH optima for growth were 60 degrees C and 6.0, respectively. The bacterial cells were found to adhere to insoluble xylan and ...
journal_title：Journal of microbiology and biotechnology
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journal_title：Journal of microbiology and biotechnology
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更新日期：2009-07-01 00:00:00
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journal_title：Journal of microbiology and biotechnology
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journal_title：Journal of microbiology and biotechnology
pub_type： 杂志文章,评审
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journal_title：Journal of microbiology and biotechnology
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journal_title：Journal of microbiology and biotechnology
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journal_title：Journal of microbiology and biotechnology
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journal_title：Journal of microbiology and biotechnology
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journal_title：Journal of microbiology and biotechnology
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journal_title：Journal of microbiology and biotechnology
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journal_title：Journal of microbiology and biotechnology
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journal_title：Journal of microbiology and biotechnology
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journal_title：Journal of microbiology and biotechnology
pub_type： 杂志文章
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journal_title：Journal of microbiology and biotechnology
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