Programmed Cell Death in Bacterial Community: Mechanisms of Action, Causes and Consequences.

Abstract:

:In the bacterial community, unicellular organisms act together as a multicellular being. Bacteria interact within the community and programmed cell death (PCD) in prokaryotes is a sort of altruistic action that enables the whole population to thrive. Genetically, encoded cell death pathways are triggered by DNA damage or nutrient starvation. Given the environmental and bacterial diversity, different PCD mechanisms are operated. Still, their biochemical and physiological aspects remain unrevealed. There are three main pathways; thymineless death, apoptosis-like death, and toxin-antitoxin systems. The discovery of PCD in bacteria has revealed the possibility of developing new antibiotics. In this review, the molecular and physiological characteristics of the three types of PCD and their development potential as antibacterial agents are addressed.

journal_name

J Microbiol Biotechnol

authors

Lee H,Lee DG

doi

10.4014/jmb.1904.04017

subject

Has Abstract

pub_date

2019-07-28 00:00:00

pages

1014-1021

issue

7

eissn

1017-7825

issn

1738-8872

pii

10.4014/jmb.1904.04017

journal_volume

29

pub_type

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