Cadaverine protects Vibrio vulnificus from superoxide stress.

Abstract:

:An electron paramagnetic resonance (EPR) signal characteristic of the 5,5'-dimethyl-1-pyrroline-N-oxide (DMPO)-OH spin adduct, which is formed from the reaction of DMPO with superoxide radicals generated by xanthine oxidase-mediated reaction, was significantly reduced by the cadaverine or Escherichia coli Mn-containing superoxide dismutase (MnSOD). Likewise, cytochrome c reduction by superoxide was inhibited by cadaverine, and the inhibition level increased in proportion to the level of cadaverine. The cadA mutant of Vibrio vulnificus, which does not produce cadaverine because of the lack of lysine decarboxylase, exhibits less tolerance to superoxide stress in comparison with wild type. The results indicate that cadaverine scavenges superoxide radicals, and protects cells from oxidative stress.

journal_name

J Microbiol Biotechnol

authors

Kang IH,Kim JS,Kim EJ,Lee JK

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

176-9

issue

1

eissn

1017-7825

issn

1738-8872

journal_volume

17

pub_type

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