The Inhibitory Effect of Gut Microbiota and Its Metabolites on Colorectal Cancer.

Abstract:

:Colorectal cancer (CRC) is regarded as one of the most common and deadly forms of cancer. Gut microbiota is vital to retain and promote several functions of intestinal. Although previous researches have shown that some gut microbiota have the abilities to inhibit tumorigenesis and prevent cancer from progressing, they have not yet clearly identified associative mechanisms. This review not only concentrates on the antitumor effects of metabolites produced by gut microbiota, for example, SCFA, ferrichrome, urolithins, equol and conjugated linoleic acids, but also the molecules which constituted the bacterial cell wall have the antitumor effect in the host, including lipopolysaccharide, lipoteichoic acid, β-glucans and peptidoglycan. The aim of our review is to develop a possible therapeutic method, which use the products of gut microbiota metabolism or gut microbiota constituents to help treat or prevent colorectal cancer.

journal_name

J Microbiol Biotechnol

authors

Chen C,Li H

doi

10.4014/jmb.2002.02032

subject

Has Abstract

pub_date

2020-11-28 00:00:00

pages

1607-1613

issue

11

eissn

1017-7825

issn

1738-8872

pii

jmb.2002.02032

journal_volume

30

pub_type

杂志文章,评审
  • Application of the rpoS gene for species-specific detection of Vibrio vulnificus by real-time PCR.

    abstract::Vibrio vulnificus is a causative agent of serious diseases in humans, resulting from the contact of wound with seawater or consumption of raw seafood. Several studies aimed at detecting V. vulnificus have targeted vvh as a representative virulence toxin gene belonging to the bacterium. In this study, we targeted the r...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.0800.176

    authors: Kim DG,Ahn SH,Kim LH,Park KJ,Hong YK,Kong IS

    更新日期:2008-11-01 00:00:00

  • Identification of a Gene Involved in the Negative Regulation of Pyomelanin Production in Ralstonia solanacearum.

    abstract::Ralstonia solanacearum causes bacterial wilt in a wide variety of host plant species and produces a melanin-like blackish-brown pigment in stationary phase when grown in minimal medium supplemented with tyrosine. To study melanin production regulation in R. solanacearum, five mutants exhibiting overproduction of melan...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1705.05049

    authors: Ahmad S,Lee SY,Khan R,Kong HG,Son GJ,Roy N,Choi K,Lee SW

    更新日期:2017-09-28 00:00:00

  • Purification and identification of a novel antifungal protein secreted by Penicillium citrinum from the Southwest Indian Ocean.

    abstract::A novel antifungal protein produced by the fungal strain Penicillium citrinum W1, which was isolated from a Southwest Indian Ocean sediment sample, was purified and characterized. The culture supernatant of P. citrinum W1 inhibited the mycelial growth of some plant pathogenic fungi. After saturation of P. citrinum W1 ...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1405.05008

    authors: Wen C,Guo W,Chen X

    更新日期:2014-10-01 00:00:00

  • Genetic characterization of two putative toxin-antitoxin systems on cryptic plasmids from Bacillus thuringiensis strain YBT-1520.

    abstract::A novel putative toxin-antitoxin segregational stability system named KyAB system was identified in a novel native plasmid pBMB8240 from Bacillus thuringiensis strain YBT-1520, based on sequences homology with other toxin-antitoxin systems, the lethal activity of the KyB putative toxin in Escherichia coli and the stab...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:

    authors: Liu X,Zhu S,Ye W,Ruan L,Yu Z,Zhao C,Sun M

    更新日期:2008-10-01 00:00:00

  • Inhibition of Monoamine Oxidase by Anithiactins from Streptomyces sp.

    abstract::Monoamine oxidase (MAO) is found in most cell types and catalyzes the oxidation of monoamines. Three anithiactins (A-C, modified 2-phenylthiazoles) isolated from Streptomyces sp. were tested for inhibitory activity of two isoforms, MAO-A and MAO-B. Anithiactin A was effective and selective for the inhibition of MAO-A,...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1505.05020

    authors: Lee HW,Jung WK,Kim HJ,Jeong YS,Nam SJ,Kang H,Kim H

    更新日期:2015-09-01 00:00:00

  • Removal of organic load from olive washing water by an aerated submerged biofilter and profiling of the bacterial community involved in the process.

    abstract::The present work aims to use a biofilter technology (aerated submerged filters) for the aerobic transformation at laboratory-scale of olive washing water (OWW) generated in the first steps of olive oil processing, as well as the genetic profiling and identification to the species level of the bacteria involved in the ...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:

    authors: Pozo C,Rodelas B,Martínez-Toledo MV,Vílchez R,González-López J

    更新日期:2007-05-01 00:00:00

  • Change of sludge consortium in response to sequential adaptation to benzene, toluene, and o-xylene.

    abstract::Activated sludge was sequentially adapted to benzene, toluene, and o-xylene (BTX) to study the effects on the change of microbial community. Sludge adapted to BTX separately degraded each by various rates in the following order; toluene>o-xylene>benzene. Degradation rates were increased after exposure to repeated spik...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:

    authors: Park JY,Sang BI

    更新日期:2007-11-01 00:00:00

  • Purification and Characterization of the Laccase Involved in Dye Decolorization by the White-Rot Fungus Marasmius scorodonius.

    abstract::Marasmius scorodonius secretes an extracellular laccase in potato dextrose broth, and this enzyme was purified up to 206-fold using (NH4)2SO4 precipitation and a Hi-trap Q Sepharose column. The molecular mass of the purified laccase was estimated to be ~67 kDa by SDS-PAGE. The UV/vis spectrum of the enzyme was nontypi...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1701.01004

    authors: Jeon SJ,Lim SJ

    更新日期:2017-06-28 00:00:00

  • Selection of High Laccase-Producing Coriolopsis gallica Strain T906: Mutation Breeding, Strain Characterization, and Features of the Extracellular Laccases.

    abstract::Commercial application of laccase is often hampered by insufficient enzyme stocks, with very low yields obtained from natural sources. This study aimed to improve laccase production by mutation of a Coriolopsis gallica strain and to determine the biological properties of the mutant. The high-yield laccase strain C. ga...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1604.04011

    authors: Xu X,Feng L,Han Z,Luo S,Wu A,Xie J

    更新日期:2016-09-28 00:00:00

  • Kinetics of a cloned special ginsenosidase hydrolyzing 3-O-glucoside of multi-protopanaxadiol-type ginsenosides, named ginsenosidase type III.

    abstract::In this paper, the kinetics of a cloned special glucosidase, named ginsenosidase type III hydrolyzing 3-O-glucoside of multi-protopanaxadiol (PPD)-type ginsenosides, were investigated. The gene (bgpA) encoding this enzyme was cloned from a Terrabacter ginsenosidimutans strain and then expressed in E. coli cells. Ginse...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1107.07066

    authors: Jin XF,Yu HS,Wang DM,Liu TQ,Liu CY,An DS,Im WT,Kim SG,Jin FX

    更新日期:2012-03-01 00:00:00

  • Preparation of branched dextran microspheres of soluble interferon-alpha and its activity in vitro and in vivo.

    abstract::The study objective was to prepare biodegradable branched dextran microspheres encapsulated with His-tagged interferon-alpha (BDM-hIFN-alpha) and evaluate its activity in vitro and in vivo. The glycidyl methacrylate derivatized dextrans (Dex-GMA) as precursor was primarily synthesized by substituting hydroxyl groups o...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1007.07060

    authors: Hong H,Jo JR,Yeon JH,Hong JT,Jung KH,Yoo SK,Jang BC

    更新日期:2011-02-01 00:00:00

  • Construction of amylolytic industrial brewing yeast strain with high glutathione content for manufacturing beer with improved anti-staling capability and flavor.

    abstract::Glutathione in beer works as the main antioxidant compounds which correlates with beer flavor stability. High residual sugars in beer contribute to major non-volatile components which correlate to high caloric content. In this work, Saccharomyces cerevisiae GSH1 gene encoding glutamylcysteine synthetase and Scharomyco...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1004.04007

    authors: Wang J,Wang ZY,He XP,Zhang BR

    更新日期:2010-11-01 00:00:00

  • Production of a platelet aggregation inhibitor, salmosin, by high cell density fermentation of recombinant Escherichia coli.

    abstract::Optimal conditions for a high cell density fermentation were investigated in a recombinant Escherichia coli producing salmosin, a platelet aggregation inhibitor. The optimized carbon and nitrogen sources were glycerol 10 g/l, yeast extract 30 g/l, and bacto-tryptone 10 g/l, yielding the dry cell weight (DCW) of 10.61 ...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1105.05014

    authors: Seo MJ,Choi HJ,Chung KH,Pyun YR

    更新日期:2011-10-01 00:00:00

  • Pinus Densiflora Bark Extract (PineXol) Decreases Adiposity in Mice by Down-Regulation of Hepatic De Novo Lipogenesis and Adipogenesis in White Adipose Tissue.

    abstract::PineXol, extracted from Korean red pine bark, has beneficial effects, such as antioxidant, antiinflammatory, and antilipogenic activities in vitro. We tested the hypothesis that PineXol supplementation could have anti-obesity effects on mice fed a high-fat diet (HFD). Four-week-old male C57BL/6 mice were fed normal ch...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1612.12037

    authors: Ahn H,Go GW

    更新日期:2017-04-28 00:00:00

  • Characterization and Antioxidant Activity of the Exopolysaccharide Produced by Bacillus amyloliquefaciens GSBa-1.

    abstract::The exopolysaccharide (EPS) produced by Bacillus amyloliquefaciens GSBa-1 was isolated and purified by ethanol precipitation, and DEAE-cellulose and Sepharose CL-6B chromatographies. The molecular mass of the purified EPS was determined to be 54 kDa. Monosaccharide analysis showed that the EPS was composed of predomin...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1801.01012

    authors: Zhao W,Zhang J,Jiang YY,Zhao X,Hao XN,Li L,Yang ZN

    更新日期:2018-08-28 00:00:00

  • Biodegradation of di-n-butyl phthalate by Rhodococcus sp. JDC-11 and molecular detection of 3, 4-phthalate dioxygenase gene.

    abstract::Rhodococcus sp. JDC-11, capable of utilizing di-n-butyl phthalate (DBP) as the sole source of carbon and energy, was isolated from sewage sludge and confirmed mainly based on 16S rRNA gene sequence analysis. The optimum pH, temperature, and agitation rate for DBP degradation by Rhodococcus sp. JDC-11 was 8.0, 30 degre...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1004.04034

    authors: Jin DC,Liang RX,Dai QY,Zhang RY,Wu XL,Chao WL

    更新日期:2010-10-01 00:00:00

  • Ecotype-dependent genetic regulation of bolting time in the Arabidopsis mutants with increased number of leaves.

    abstract::Leaves are the major biomass-producing organs in herbaceous plants and mainly develop during vegetative stage by activities of shoot apical meristem. There is a strong correlation between leaf number and bolting, a characteristic phenotype during the transition to reproductive phase in Arabidopsis thaliana. In order t...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:

    authors: Lee BH

    更新日期:2009-06-01 00:00:00

  • Gene cloning, expression, and characterization of a beta-agarase, agaB34,from Agarivorans albus YKW-34.

    abstract::A beta-agarase gene, agaB34, was functionally cloned from the genomic DNA of a marine bacterium, Agarivorans albus YKW-34. The open reading frame of agaB34 consisted of 1,362 bp encoding 453 amino acids. The deduced amino acid sequence, consisting of a typical N-terminal signal peptide followed by a catalytic domain o...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:

    authors: Fu XT,Pan CH,Lin H,Kim SM

    更新日期:2009-03-01 00:00:00

  • Paeonia lactiflora Inhibits Cell Wall Synthesis and Triggers Membrane Depolarization in Candida albicans.

    abstract::Fungal cell walls and cell membranes are the main targets of antifungals. In this study, we report on the antifungal activity of an ethanol extract from Paeonia lactiflora against Candida albicans, showing that the antifungal activity is associated with the synergistic actions of preventing cell wall synthesis, enabli...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1611.11064

    authors: Lee HS,Kim Y

    更新日期:2017-02-28 00:00:00

  • Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus inhibits TBK1 to evade interferon-mediated response.

    abstract::Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging phlebovirus of the Phenuiviridae family that has been circulating in East Asian countries, such as China, Japan, and South Korea. Despite the increasing infection rates and relatively high mortality rate, there is limited information available re...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.2008.08048

    authors: Lee JK,Shin OS

    更新日期:2020-12-31 00:00:00

  • Reduction of Trimethylamine Off-Odor by Lactic Acid Bacteria Isolated from Korean Traditional Fermented Food and Their In Situ Application.

    abstract::Trimethylamine (TMA) is a well-known off-odor compound in fish and fishery products and is a metabolic product of trimethylamine N-oxide (TMAO) generated by the enzymatic action of microorganisms. The off-odor is a factor that can debase the value of fish and fishery products. The present study aimed to remove TMA usi...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.2005.05007

    authors: Park SK,Jo DM,Yu D,Khan F,Lee YB,Kim YM

    更新日期:2020-10-28 00:00:00

  • Intermolecular interaction between Cry2Aa and Cyt1Aa and its effect on larvicidal activity against Culex quinquefasciatus.

    abstract::The Cyt1Aa protein of Bacillus thuringiensis susbp. israelensis elaborates demonstrable toxicity to mosquito larvae, but more importantly, it enhances the larvicidal activity of this species Cry proteins (Cry11Aa, Cry4Aa, and Cry4Ba) and delays the phenotypic expression of resistance to these that has evolved in Culex...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1301.01062

    authors: Bideshi DK,Waldrop G,Fernandez-Luna MT,Diaz-Mendoza M,Wirth MC,Johnson JJ,Park HW,Federici BA

    更新日期:2013-08-01 00:00:00

  • Evaluation of inhibitory effects of thiobarbituric acid derivatives targeting HCV NS5B polymerase.

    abstract::A series of thiobarbituric acid derivatives were constructed and evaluated for inhibitory activity on hepatitis C virus NS5B polymerase. In biochemical assays using purified viral polymerase and RNA template, the IC(50) value was improved to 0.41 microM from the original compound's 1.7 microM value. In HCV subgenomic ...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:

    authors: Lee JH,Lee S,Park MY,Ha HJ,Myung H

    更新日期:2010-03-01 00:00:00

  • Active component of Fatsia japonica enhances the transduction efficiency of Tat-SOD fusion protein both in vitro and in vivo.

    abstract::It has been reported that Tat-SOD can be directly transduced into mammalian cells and skin and acts as a potential therapeutic protein in various diseases. To isolate the compound that can enhance the transduction efficiency of Tat-SOD, we screened a number of natural products. 3-O-[beta-D-Glucopyranosyl(1-->4)-alpha-...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:

    authors: Lee SH,Kim SY,Kim DW,Jang SH,Lim SS,Kwon HJ,Kang TC,Won MH,Kang IJ,Lee KS,Park J,Eum WS,Choi SY

    更新日期:2008-09-01 00:00:00

  • LasR Might Act as an Intermediate in Overproduction of Phenazines in the Absence of RpoS in Pseudomonas aeruginosa.

    abstract::As an opportunistic bacterial pathogen, Pseudomonas aeruginosa PAO1 contains two phenazineproducing gene operons, phzA1B1C1D1E1F1G1 (phz1) and phzA2B2C2D2E2F2G2 (phz2), each of which is independently capable of encoding all enzymes for biosynthesizing phenazines, including phenazine-1-carboxylic acid and its derivativ...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1904.04029

    authors: He Q,Feng Z,Wang Y,Wang K,Zhang K,Kai L,Hao X,Yu Z,Chen L,Ge Y

    更新日期:2019-08-28 00:00:00

  • Comparative study of rhizobacterial community structure of plant species in oil-contaminated soil.

    abstract::In this study, the identity and distribution of plants and the structure of their associated rhizobacterial communities were examined in an oil-contaminated site. The number of plant species that formed a community or were scattered was 24. The species living in soil highly contaminated with total petroleum hydrocarbo...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1003.03022

    authors: Lee EH,Cho KS,Kim J

    更新日期:2010-09-01 00:00:00

  • Regulation of Innate Immune Response to Fungal Infection in Caenorhabditis elegans by SHN-1/SHANK.

    abstract::In Caenorhabditis elegans, SHN-1 is the homologue of SHANK, a scaffolding protein. In this study, we determined the molecular basis for SHN-1/SHANK in the regulation of innate immune response to fungal infection. Mutation of shn-1 increased the susceptibility to Candida albicans infection and suppressed the innate imm...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.2006.06025

    authors: Sun L,Li H,Zhao L,Liao K

    更新日期:2020-11-28 00:00:00

  • Impact of fermentation rate changes on potential hydrogen sulfide concentrations in wine.

    abstract::The correlation between alcoholic fermentation rate, measured as carbon dioxide (CO2) evolution, and the rate of hydrogen sulfide (H2S) formation during wine production was investigated. Both rates and the resulting concentration peaks in fermentor headspace H2S were directly impacted by yeast assimilable nitrogenous ...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1010.10058

    authors: Butzke CE,Park SK

    更新日期:2011-05-01 00:00:00

  • Changes in Structural and Functional Responses of Bacterial Communities under Different Levels of Long-Term Compost Application in Paddy Soils.

    abstract::Soils amended for long-term with high levels of compost demonstrated greater abundance of bacterial members of the phylum Bacteroidetes whereas a decreasing trend in the relative abundance of phylum Acidobacteria was noted with increasing levels of compost. Metabolic profiles predicted by PICRUSt demonstrated differen...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1811.11018

    authors: Samaddar S,Han GH,Chauhan P,Chatterjee P,Jeon S,Sa T

    更新日期:2019-02-28 00:00:00

  • Characterization of Polyester Cloth as an Alternative Separator to Nafion Membrane in Microbial Fuel Cells for Bioelectricity Generation Using Swine Wastewater.

    abstract::Polyester cloth (PC) was selected as a prospective inexpensive substitute separator material for microbial fuel cells (MFCs). PC was compared with a traditional Nafion proton exchange membrane (PEM) as an MFC separator by analyzing its physical and electrochemical properties. A single layer of PC showed higher mass tr...

    journal_title:Journal of microbiology and biotechnology

    pub_type: 杂志文章

    doi:10.4014/jmb.1608.08040

    authors: Kim T,Kang S,Sung JH,Kang YK,Kim YH,Jang JK

    更新日期:2016-12-28 00:00:00