Abstract：
:In this study, we developed lysosome-alginate beads for application as an oral drug delivery system (ODDS). The beads harboring lysosomes, which have antimicrobial activity, and various concentrations of alginate were characterized and optimized. For application as an ODDS, pH-dependent lysosome-alginate beads were generated, and the level of lysosome release was investigated by using antimicrobial tests. At low pH, lysosomes were not released from the lysosome-alginate beads; however, at neutral pH, similar to the pH in the intestine, lysosome release was confirmed, as determined by a high antimicrobial activity. This study shows the potential of such an ODDS for the in vivo treatment of infection with pathogens.
journal_name
J Microbiol Biotechnoljournal_title
Journal of microbiology and biotechnologyauthors
Park HJ,Min J,Ahn JM,Cho SJ,Ahn JY,Kim YHdoi
10.4014/jmb.1410.10023subject
Has Abstractpub_date
2015-02-01 00:00:00pages
234-7issue
2eissn
1017-7825issn
1738-8872pii
10.4014/jmb.1410.10023journal_volume
25pub_type
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