Hydoroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus.

Abstract:

:In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to possess significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 micronM, respectively.

journal_name

J Microbiol Biotechnol

authors

Ryoo IJ,Yun BS,Lee IK,Kim YH,Lee IS,Ahn JS,Bae K,Yoo ID

doi

10.4014/jmb.1004.04028

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

1189-91

issue

8

eissn

1017-7825

issn

1738-8872

pii

JMB020-08-04

journal_volume

20

pub_type

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