The anti-sebum property of chitosan particles.

Abstract:

BACKGROUND:Seborrhea is linked to several medical and mental conditions. Although it is common, effective agents and the standardized sebum level for seborrhea are not elucidated. AIMS:To determine the efficacy of chitosan particles (CP) formulation on controlling sebum secretion, its extended effects on skin redness and texture after combining with proretinal nanoparticles (CP-PRN), and a correlation of the clinical grading with sebum levels that affect mental health. PATIENTS/METHODS:A four-week clinical trial with forty subjects was conducted. Subjects applied either CP formulation or CP-PRN during nighttime. Objective measurements including sebum levels, transepidermal water loss (TEWL), skin corneometry, skin redness, and texture were analyzed. Subjects completed a self-assessment clinical grading of skin oiliness at every visit. RESULTS:Both CP and CP-PRN significantly decreased sebum levels (P ≤ .01) at week 4 compared to baseline. CP also resulted in significant decreases in TEWL (P ≤ .05) and skin corneometry (P ≤ .05) throughout the study. A significant improvement in skin redness was observed with CP-PRN (P ≤ .01). A moderate correlation between the clinical grading and sebum levels was detected (coefficient of 0.5, P ≤ .001), with a sebum level of 106 μg cm-2 indicating emotional discomfort. One subject experienced local irritation with the CP-PRN. Mild pruritic symptoms were reported in both groups. CONCLUSIONS:Chitosan particles exhibited an interesting anti-sebum effect. It could be combined with PRN to extend benefits without losing the sebum controlling effect. The clinical grading may be useful in practice due to a modest correlation with sebum levels.

journal_name

J Cosmet Dermatol

authors

Tangkijngamvong N,Phaiyarin P,Wanichwecharungruang S,Kumtornrut C

doi

10.1111/jocd.13274

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

2135-2140

issue

8

eissn

1473-2130

issn

1473-2165

journal_volume

19

pub_type

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