Abstract:
:Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over 100 compounds detected so far. In recent years, a lot of attention has been given to the main phytochemicals present in Cannabis sativa L., namely, cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). Compared to THC, CBD has non-psychoactive effects, an advantage for clinical applications of anti-tumor benefits. The review is designed to provide an update regarding the multi-target effects of CBD in different types of cancer. The main focus is on the latest in vitro and in vivo studies that present data regarding the anti-proliferative, pro-apoptotic, cytotoxic, anti-invasive, anti-antiangiogenic, anti-inflammatory, and immunomodulatory properties of CBD together with their mechanisms of action. The latest clinical evidence of the anticancer effects of CBD is also outlined. Moreover, the main aspects of the pharmacological and toxicological profiles are given.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kis B,Ifrim FC,Buda V,Avram S,Pavel IZ,Antal D,Paunescu V,Dehelean CA,Ardelean F,Diaconeasa Z,Soica C,Danciu Cdoi
10.3390/ijms20235905subject
Has Abstractpub_date
2019-11-25 00:00:00issue
23issn
1422-0067pii
ijms20235905journal_volume
20pub_type
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