Abstract：
:The conformation spaces generated by short hydrophobic-hydrophilic (HP) lattice chains are mapped to conformation space networks (CSNs). The vertices (nodes) of the network are the conformations and the links are the transitions between them. It has been found that these networks have "small-world" properties without considering the interaction energy of the monomers in the chain, i. e. the hydrophobic or hydrophilic amino acids inside the chain. When the weight based on the interaction energy of the monomers in the chain is added to the CSNs, it is found that the weighted networks show the "scale-free" characteristic. In addition, it reveals that there is a connection between the scale-free property of the weighted CSN and the folding dynamics of the chain by investigating the relationship between the scale-free structure of the weighted CSN and the noted parameter Z score. Moreover, the modular (community) structure of weighted CSNs is also studied. These results are helpful to understand the topological properties of the CSN and the underlying free-energy landscapes.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Lai Z,Su J,Chen W,Wang Cdoi
10.3390/ijms10041808subject
Has Abstractpub_date
2009-04-21 00:00:00pages
1808-23issue
4issn
1422-0067journal_volume
10pub_type
杂志文章abstract：:Colorectal cancer is a major healthcare concern worldwide. Many experimental and clinical studies have been conducted to date to discover agents that help in the prevention of this disease. Chronic inflammation in colonic mucosa and obesity, and its related metabolic abnormalities, are considered to increase the risk ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2017-04-26 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2018-09-08 00:00:00
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更新日期：2018-10-21 00:00:00
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更新日期：2011-01-01 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-05-03 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2018-10-31 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,随机对照试验
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更新日期：2012-01-01 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-12-17 00:00:00
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journal_title：International journal of molecular sciences
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