Abstract:
:Both heroin abuse and early life stress (ELS) affect the immune system and the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, accelerated aging due to mild inflammation has been indicated in these conditions. The present study aims to compare plasma levels of apoptosis markers, inflammatory markers, and stress hormones during early heroin abstinence period. Thirty-one individuals with heroin/opioid use disorder who had heroin-ELS and 26 of their siblings who were not abusing substances (ELS), and 32 individuals with heroin/opioid use disorder without a history of ELS (heroin-no ELS) were included in the study. The levels of interleukin-6, C-reactive protein, erythrocyte sedimentation rate, albumin, alanine transaminase, aspartate transaminase, and white blood cell count were assessed as the inflammatory and biochemistry markers. Also, apoptosis markers including tumor necrosis factor (TNF)-related weak inducer of apoptosis, TNF-related apoptosis-inducing ligand, soluble tumor necrosis factor receptor type I as apoptosis markers were detected by enzyme-linked immunosorbent assay. ELS was simultaneously evaluated using the Childhood Trauma Questionnaire, Minnesota Multiphasic Personality Inventory, and beck depression inventory scales. Besides, heroin craving was assessed by Daily Drinking/Drug Questionnaire score in individuals with heroin use disorder. This is the first study to evaluate the inflammatory, stress, and apoptosis markers during heroin abstinence, supporting the association between ELS and peripheral pro-inflammatory markers' levels and HPA axis.
journal_name
Eur Addict Resjournal_title
European addiction researchauthors
Moeini M,Esmaeil N,Mokhtari HR,Eskandari N,Banafshe HRdoi
10.1159/000503880subject
Has Abstractpub_date
2020-01-01 00:00:00pages
28-39issue
1eissn
1022-6877issn
1421-9891pii
000503880journal_volume
26pub_type
杂志文章abstract::In Spain, detoxification in general hospitals plays an important role in the medical care of patients. We aim to provide clinicians with information on the prevalence and correlates of psychiatric co-morbidity in drug abusers in detoxification. A sample of 115 substance-abuse inpatients (mean age 31.9 +/- 6.4 years) i...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000104881
更新日期:2007-01-01 00:00:00
abstract:UNLABELLED:This study evaluated automated techniques including personalized normative feedback and protective behavioral strategies, for brief interventions intended to reduce peak alcohol concentrations in university students. After completing baseline assessment, a total of 1,678 hazardous-drinking consumers were ran...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000381017
更新日期:2015-01-01 00:00:00
abstract::The objectives of the community-based Early Developmental Stages of Psychopathology (EDSP) Study are described along with a detailed account of the overall design, special design features, sample characteristics and instruments used. The EDSP employed a prospective-longitudinal design to study substance use and other ...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000052043
更新日期:2000-12-01 00:00:00
abstract:AIMS:To describe and assess trends in the use of hallucinogens and other adjunct drugs over a 5-year period. DESIGN:Repeated-measures cross-sectional survey. SETTING AND PARTICIPANTS:Annual magazine-based survey targeting people who use drugs in dance contexts. MEASUREMENTS:Lifetime use prevalence (ever used); age o...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000095816
更新日期:2007-01-01 00:00:00
abstract::Alcohol and illicit drug use has a significant impact on global health. Alcohol consumption is increasing worldwide, particularly in developing countries and countries in transition, leading to an increasing number of health and social problems, both acute and chronic. Illicit drug use is also increasing, particularly...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000050727
更新日期:2001-08-01 00:00:00
abstract:AIMS:Qualitative studies find that men and women in Russia have different preferences for alcoholic beverages, but quantitative evidence for gender differences in beverage type choice remains scarce. The purpose of this article is to test numerically whether and to what extent men and women in Russia differ in terms of...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000342313
更新日期:2013-01-01 00:00:00
abstract:AIMS:To explore previously unreported rates and trends in opioid-related mortality in Israel, 2005-2014. METHODS:Data was obtained from the national database on causes of death. Drug poisoning deaths were divided into opioid-related deaths and deaths related to other drugs according to International Classification of ...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000485033
更新日期:2017-01-01 00:00:00
abstract::We tested the use of some subscales of the psychiatric symptom checklist SCL-90-R in predicting relapse within a 1-year follow-up period after a combined detoxification- and abstinence-focused day patient psychotherapy program in 20 men and 13 women with alcohol dependence. Scores of the SCL-90-R subscales interperson...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000066131
更新日期:2002-11-01 00:00:00
abstract::In this paper, the effectiveness of the treatment program developed by Proyecto Hombre ('Project Mankind') in Asturias, Spain, is evaluated. In a long-term follow-up (range from 73 days to 8 years) with a sample of 249 subjects, the results obtained by subjects completing the treatment (194) were compared with pre-tre...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000049484
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Alcohol consumption is one of the most important factors for disease and disability in Europe. In clinical trials, nalmefene has resulted in a significant reduction in the number of heavy-drinking days (HDDs) per month and total alcohol consumption (TAC) among alcohol-dependent patients versus placebo. METH...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000362408
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Alcohol use among medical specialists remains a delicate topic. However, the number of prevalence studies remains very limited in Western European countries. AIMS:To explore alcohol use and hazardous drinking among male and female medical specialists. METHODS:All medical specialists in Belgium--a typical W...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000341993
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Consumption of natural cannabis (NC) and synthetic cannabinoids (SCs) has been associated with psychotic disorders. We compared the prevalence of use, consumer profiles, and psychosis-inducing potential of NC and SCs in a specific high-risk population. METHODS:This prospective pilot study included 332 patie...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000479554
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIM:Heroin dependence is a chronic relapsing disorder characterized by the compulsion to seek and use heroin. Stress and craving are seen as key factors for heroin use. Moreover, altered hypothalamic-pituitary-adrenal (HPA) axis function has been frequently reported. However, the acute effects of diacetylmor...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000334411
更新日期:2012-01-01 00:00:00
abstract::γ-Butyrolactone (GBL) is a popular drug of abuse which is easily available over the internet. Following a UK classification change to a class C drug in January 2010, internet supply has become difficult. Some of the effects have resulted in sourcing GBL from industrial solvents. We report a case of a 24-year-old man w...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000324343
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Therapeutic communities (TCs) are drug-free residential settings, focused on psychosocial rehabilitation. While TCs are considered an effective method, the bulk of the research evidence is from poorly controlled studies. The goal of this study was to evaluate TC effectiveness in terms of abstinence and to de...
journal_title:European addiction research
pub_type: 杂志文章,评审
doi:10.1159/000331007
更新日期:2012-01-01 00:00:00
abstract::This longitudinal study of 600 families concentrates on the influence of parental anti-smoking socialization by examining both (a) the effects of eight indicators of anti-smoking socialization on adolescent smoking and (b) the influence of parental smoking on the effectiveness of their anti-smoking socialization. Robu...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000088580
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The aim of the study was to examine the practicability and implementation efficacy of an alcohol outpatient detoxification model and the concomitant 'motivational' psychotherapeutic approach. METHOD:This was an open prospective study to examine the implementation efficacy, practicability and medical safety ...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000079840
更新日期:2004-01-01 00:00:00
abstract:AIMS:To analyse correlates of anabolic androgenic steroids (AAS) use in the general male population. DESIGN:A national household survey. PARTICIPANTS:Individuals aged 15-64 years in Sweden. MEASUREMENTS:AAS use and potential correlates of AAS use, including demographic data, financial situation, physical training, a...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000333037
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:It has been determined that cannabis has adverse effects on brain tissue, and that increased S100 calcium binding protein B (S100B) blood levels are markers of neuronal damage. Therefore, the aim of this study was to evaluate the S100B levels in cannabis use disorder. METHOD:Thirty-two patients with cannabi...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000442046
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:A pre-post pilot study was conducted to test the feasibility, acceptability, and potential effectiveness of a fully automatized computer-based intervention targeting hazardous drinking and depressiveness in proactively recruited health care patients (HCPs). To address the importance of the sample selection w...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000499040
更新日期:2019-01-01 00:00:00
abstract::The aim of this study was to investigate to what extent alcohol-specific parenting practices relate to adolescents' alcohol use, binge drinking, and alcohol-related problems, and whether these associations are moderated by socioeconomic status (SES), i.e. parents' education level and family income. The present data we...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000110408
更新日期:2008-01-01 00:00:00
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journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000355832
更新日期:2014-01-01 00:00:00
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journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000059380
更新日期:2002-06-01 00:00:00
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journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000441220
更新日期:2016-01-01 00:00:00
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journal_title:European addiction research
pub_type: 临床试验,杂志文章
doi:10.1159/000052035
更新日期:1998-01-01 00:00:00
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journal_title:European addiction research
pub_type: 杂志文章,评审
doi:10.1159/000018931
更新日期:1998-09-01 00:00:00
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journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000210041
更新日期:2009-01-01 00:00:00
abstract:AIMS:There is a scarcity of clinical trials on psychological treatments for concurrent borderline personality disorder (BPD) and substance use disorder (SUD). Mentalization-based treatment (MBT) have shown efficacy in several trials on BPD. The aim of the present study was to examine the feasibility and effectiveness o...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000485564
更新日期:2018-01-01 00:00:00
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journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000446428
更新日期:2016-01-01 00:00:00
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journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000506738
更新日期:2021-01-01 00:00:00