Abstract:
:A steady increase in the incidence of osteoarthritis and other rheumatic diseases has been observed in recent decades, including autoimmune conditions such as rheumatoid arthritis, spondyloarthropathies, systemic lupus erythematosus, systemic sclerosis, and Sjögren's syndrome. Rheumatic and autoimmune diseases (RADs) are characterized by the inflammation of joints, muscles, or other connective tissues. In addition to often experiencing debilitating mobility and pain, RAD patients are also at a higher risk of suffering comorbidities such as cardiovascular or infectious events. Given the socioeconomic impact of RADs, broad research efforts have been dedicated to these diseases worldwide. In the present work, we applied literature mining platforms to identify "popular" proteins closely related to RADs. The platform is based on publicly available literature. The results not only will enable the systematic prioritization of candidates to perform targeted proteomics studies but also may lead to a greater insight into the key pathogenic processes of these disorders.
journal_name
J Proteome Resjournal_title
Journal of proteome researchauthors
Ruiz-Romero C,Lam MPY,Nilsson P,Önnerfjord P,Utz PJ,Van Eyk JE,Venkatraman V,Fert-Bober J,Watt FE,Blanco FJdoi
10.1021/acs.jproteome.9b00360subject
Has Abstractpub_date
2019-12-06 00:00:00pages
4231-4239issue
12eissn
1535-3893issn
1535-3907journal_volume
18pub_type
杂志文章abstract::Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identi...
journal_title:Journal of proteome research
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
abstract::The protein expression pattern in the cytosol fraction of the adriamycin resistant MCF-7 cell line (MCF-7/ADR) was compared to that of the parental MCF-7 cell line using two-dimensional gel electrophoresis and mass spectrometry. Twenty proteins with altered abundances were identified and studied in MCF-7/ADR. Both up ...
journal_title:Journal of proteome research
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journal_title:Journal of proteome research
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journal_title:Journal of proteome research
pub_type: 杂志文章
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更新日期:2016-12-02 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
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journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/acs.jproteome.6b00873
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journal_title:Journal of proteome research
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journal_title:Journal of proteome research
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
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更新日期:2009-05-01 00:00:00
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journal_title:Journal of proteome research
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更新日期:2015-03-06 00:00:00
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journal_title:Journal of proteome research
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journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/acs.jproteome.6b00208
更新日期:2016-06-03 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/pr900927y
更新日期:2010-02-05 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/pr800036d
更新日期:2008-07-01 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/pr070440q
更新日期:2007-12-01 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/pr2007957
更新日期:2012-04-06 00:00:00
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更新日期:2006-04-01 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/pr801086k
更新日期:2009-05-01 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章,评审
doi:10.1021/pr0499601
更新日期:2004-09-01 00:00:00
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journal_title:Journal of proteome research
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更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of proteome research
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journal_title:Journal of proteome research
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更新日期:2009-03-01 00:00:00
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journal_title:Journal of proteome research
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更新日期:2008-11-01 00:00:00
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journal_title:Journal of proteome research
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