Abstract:
:Leukocytes play an important role in the progression of disease and leukocyte-derived proteins are associated with the pathogenesis of the disease. Leukocyte activation causes production of inflammatory mediators, over-expression of cell surface adhesion molecules, and an increase in migration and infiltration, phagocytosis, and degranulation, as well as receptor phosphorylation and signal transduction. An increasing number of studies on the application of leukocyte proteomics have appeared in mapping protein profiles of inflammatory cells, contributing to the understanding of potential mechanisms involved in leukocyte function. Together with improvements in proteomic technology in leukocyte research, leukocyte proteomic analysis becomes more simple, rapid, flexible, sensitive, and specific. This enables proteomic investigation of activated or non-activated leukocytes to be highly focused on defined suborgans or specific signaling pathways. Research in leukocyte proteomics is progressing from fingerprinting to functioning, human cell lines to primary leukocytes, non-activated cells to inflammatory mediator-stimulated cells, in vitro culture to in vivo challenge, and animal models to human disease. A number of newly identified proteins from leukocyte proteomics may offer new mechanism-orientated targets for drug discovery and development.
journal_name
J Proteome Resjournal_title
Journal of proteome researchauthors
Wang X,Zhao H,Andersson Rdoi
10.1021/pr0499601keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
921-9issue
5eissn
1535-3893issn
1535-3907journal_volume
3pub_type
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journal_title:Journal of proteome research
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journal_title:Journal of proteome research
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journal_title:Journal of proteome research
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journal_title:Journal of proteome research
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journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/acs.jproteome.0c00406
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journal_title:Journal of proteome research
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更新日期:2011-07-01 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/pr060167c
更新日期:2006-08-01 00:00:00
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更新日期:2005-05-01 00:00:00
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journal_title:Journal of proteome research
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更新日期:2010-09-03 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/acs.jproteome.9b00179
更新日期:2019-07-05 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/acs.jproteome.5b00450
更新日期:2015-12-04 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/acs.jproteome.5b00178
更新日期:2015-09-04 00:00:00
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journal_title:Journal of proteome research
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abstract::An important mechanism by which plants defend themselves against pathogens is the rapid execution of a hypersensitive response (HR). Tomato plants containing the Cf-4 resistance gene mount an HR that relies on the activation of phosphorylation cascades, when challenged with the Avr4 elicitor secreted by the pathogenic...
journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/pr800619h
更新日期:2009-03-01 00:00:00
abstract::Royal jelly (RJ) is an exclusive food for queen honey bee (Apis mellifera L.) that is synthesized and secreted by young worker bees. RJ is also widely used in medical products, cosmetics, and as health foods. However, little is known about RJ functionality and the total protein components, although recent research is ...
journal_title:Journal of proteome research
pub_type: 杂志文章
doi:10.1021/pr800061j
更新日期:2008-08-01 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章,评审
doi:10.1021/acs.jproteome.5b00857
更新日期:2016-01-04 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
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更新日期:2013-12-06 00:00:00
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journal_title:Journal of proteome research
pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
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更新日期:2012-12-07 00:00:00
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更新日期:2014-12-05 00:00:00
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journal_title:Journal of proteome research
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更新日期:2013-07-05 00:00:00
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journal_title:Journal of proteome research
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更新日期:2012-05-04 00:00:00
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