Abstract：
:The protein expression pattern in the cytosol fraction of the adriamycin resistant MCF-7 cell line (MCF-7/ADR) was compared to that of the parental MCF-7 cell line using two-dimensional gel electrophoresis and mass spectrometry. Twenty proteins with altered abundances were identified and studied in MCF-7/ADR. Both up regulation and down regulation are characterized. The most striking differences were found for proteins that were uniquely expressed in this cell line and not detectable in the parental MCF-7 cell line. These proteins include annexin I, the neuronal ubiquitin carboxyl hydrolase isoenzyme L-1 (also known as PGP9.5), glutathione-S-transferase pi class, nicotinamide N-methyltransferase, and interleukin-18 precursor. On the other hand, catechol-O-methyltransferase was expressed in the parental cell line, but was not detected in the adriamycin resistant cell line. This protein expression pattern was unique to MCF-7/ADR and not observed in MCF-7 cell lines selected for resistant to etoposide, mitoxantrone or melphalan.
journal_name
J Proteome Resjournal_title
Journal of proteome researchauthors
Gehrmann ML,Fenselau C,Hathout Ydoi
10.1021/pr0340577keywords:
subject
Has Abstractpub_date
2004-05-01 00:00:00pages
403-9issue
3eissn
1535-3893issn
1535-3907journal_volume
3pub_type
杂志文章abstract：:Numerous reports have predicted/hypothesized a role for probenazole-induced protein (PBZ1) as a molecular marker in rice self-defense mechanism. However, the precise function of PBZ1 remains unknown. In the present study, we examined PBZ1 as a putative cell death marker in rice. For this, we focused our attention on a...
journal_title：Journal of proteome research
pub_type： 杂志文章
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journal_title：Journal of proteome research
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更新日期：2014-12-05 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2013-12-06 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
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abstract：:In this report, we use a proteomic strategy to identify glycoproteins on the surface of exosomes derived from myeloid-derived suppressor cells (MDSCs), and then test if selected glycoproteins contribute to exosome-mediated chemotaxis and migration of MDSCs. We report successful modification of a surface chemistry meth...
journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2017-01-06 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
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journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2015-06-05 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章,评审
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journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2014-08-01 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2014-05-02 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
doi：10.1021/acs.jproteome.9b00892
更新日期：2020-07-02 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
doi：10.1021/pr200088w
更新日期：2011-06-03 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
doi：10.1021/acs.jproteome.6b00457
更新日期：2016-10-07 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
doi：10.1021/pr900478h
更新日期：2009-11-01 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2016-11-04 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
doi：10.1021/pr050475v
更新日期：2006-04-01 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
doi：10.1021/pr0341134
更新日期：2004-05-01 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2010-05-07 00:00:00
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journal_title：Journal of proteome research
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更新日期：2005-05-01 00:00:00
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journal_title：Journal of proteome research
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更新日期：2014-02-07 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章,评审
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更新日期：2007-02-01 00:00:00
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journal_title：Journal of proteome research
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更新日期：2012-03-02 00:00:00
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journal_title：Journal of proteome research
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doi：10.1021/pr060055l
更新日期：2006-06-01 00:00:00
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journal_title：Journal of proteome research
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更新日期：2014-03-07 00:00:00
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journal_title：Journal of proteome research
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更新日期：2013-02-01 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2016-12-02 00:00:00
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journal_title：Journal of proteome research
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更新日期：2019-01-04 00:00:00
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journal_title：Journal of proteome research
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