Distinguishing between Spectral Clustering and Cluster Analysis of Mass Spectra.

abstract：:Influenza viruses continue evolving and have the ability to cause a global pandemic, so it is very important to elucidate its pathogenesis and find new treatment methods. In recent years, proteomics has made important contributions to describing the dynamic interaction between influenza viruses and their hosts, especi...

journal_title：Journal of proteome research

authors： Zhang J,Peng Q,Zhao W,Sun W,Yang J,Liu N

更新日期：2021-01-01 00:00:00

abstract：:Autosomal dominant polycystic liver disease (PCLD) is characterized by multiple liver cysts and is caused by mutations in PRKCSH (hepatocystin). Mechanisms of cystogenesis are unknown, but previous studies have shown that hepatocystin is secreted in vitro. The goal of this study was to determine the fate of hepatocyst...

journal_title：Journal of proteome research

authors： Waanders E,Lameris AL,Op den Camp HJ,Pluk W,Gloerich J,Strijk SP,Drenth JP

更新日期：2008-06-01 00:00:00

abstract：:N-glycosylation of proteins is well known to occur at asparagine residues that fall within the canonical consensus sequence N-X-S/T but has also been identified at a small number of asparagine residues within N-X-C motifs, including the N491 residue of human serotransferrin. Here we report novel glycosylation sites wi...

journal_title：Journal of proteome research

authors： Lowenthal MS,Davis KS,Formolo T,Kilpatrick LE,Phinney KW

更新日期：2016-07-01 00:00:00

abstract：:The protein expression pattern in the cytosol fraction of the adriamycin resistant MCF-7 cell line (MCF-7/ADR) was compared to that of the parental MCF-7 cell line using two-dimensional gel electrophoresis and mass spectrometry. Twenty proteins with altered abundances were identified and studied in MCF-7/ADR. Both up ...

journal_title：Journal of proteome research

authors： Gehrmann ML,Fenselau C,Hathout Y

更新日期：2004-05-01 00:00:00

abstract：:In Thailand, diabetes mellitus is the most significant risk factor for melioidosis, a severe disease caused by Burkholderia pseudomallei. In this study, neutrophils isolated from healthy or diabetic subjects were infected with B. thailandensis E555, a variant strain with a B. pseudomallei-like capsular polysaccharide ...

journal_title：Journal of proteome research

authors： Withatanung P,Kurian D,Tangjittipokin W,Plengvidhya N,Titball RW,Korbsrisate S,Stevens JM

更新日期：2019-07-05 00:00:00

abstract：:The secreted proteins of bacteria are usually accompanied by virulence factors, which can cause inflammation and damage host cells. Identifying the secretomes arising from the interactions of bacteria and host cells could therefore increase understanding of the mechanisms during initial pathogenesis. The present study...

journal_title：Journal of proteome research

authors： Chiu KH,Wang LH,Tsai TT,Lei HY,Liao PC

更新日期：2017-01-06 00:00:00

abstract：:Bone proteomics is an expanding field for understanding protein changes associated with disease as well as characterizing and detecting proteins preserved in fossil bone. Most previous studies have utilized a protocol with demineralization and extraction approach to isolate and characterize proteins from bone. Through...

journal_title：Journal of proteome research

authors： Cleland TP

更新日期：2018-01-05 00:00:00

abstract：:This paper describes a metabonomic study of prenatal disorders using nuclear magnetic resonance (NMR) spectroscopy of amniotic fluid (AF) collected in the second trimester of pregnancy, to search for metabolite markers of fetal malformations, prediagnostic gestational diabetes (GD), preterm delivery (PTD), early ruptu...

journal_title：Journal of proteome research

authors： Graca G,Duarte IF,Barros AS,Goodfellow BJ,Diaz SO,Pinto J,Carreira IM,Galhano E,Pita C,Gil AM

更新日期：2010-11-05 00:00:00

abstract：:The notion of a gamete recognition system that alerts females to the presence of gametes in their reproductive tract profoundly influences our understanding of the physiology of events leading to conception and the bearing of offspring. Here, we show that the female responds to gametes within her tract by modulating t...

journal_title：Journal of proteome research

authors： Georgiou AS,Snijders AP,Sostaric E,Aflatoonian R,Vazquez JL,Vazquez JM,Roca J,Martinez EA,Wright PC,Fazeli A

更新日期：2007-12-01 00:00:00

abstract：:Sensitive detection of molecular biomarkers in clinical samples is crucially important in disease diagnostics. This paper reports the development of an aptamer microarray platform combined with sol-gel technology to identify low-abundance targets in complex serum samples. Because of the nanoporous structure of the sol...

journal_title：Journal of proteome research

authors： Ahn JY,Lee SW,Kang HS,Jo M,Lee DK,Laurell T,Kim S

更新日期：2010-11-05 00:00:00

abstract：:Ozonated autohemotherapy (O3-AHT) is a medical approach during which blood obtained from the patient is ozonated and injected back into the body. Despite an increasing number of evidence that O3-AHT is safe, this type of therapy remains controversial. To extend knowledge about the changes in blood evoked by O3-AHT, LC...

journal_title：Journal of proteome research

authors： Ciborowski M,Lipska A,Godzien J,Ferrarini A,Korsak J,Radziwon P,Tomasiak M,Barbas C

更新日期：2012-12-07 00:00:00

abstract：:When analyzing proteins in complex samples using tandem mass spectrometry of peptides generated by proteolysis, the inference of proteins can be ambiguous, even with well-validated peptides. Unresolved questions include whether to show all possible proteins vs a minimal list, what to do when proteins are inferred ambi...

journal_title：Journal of proteome research

authors： Meyer-Arendt K,Old WM,Houel S,Renganathan K,Eichelberger B,Resing KA,Ahn NG

更新日期：2011-07-01 00:00:00

abstract：:Campylobacter jejuni, an important foodborne microorganism, poses severe and emergent threats to human health as antibiotic resistance becomes increasingly prevalent. The mechanisms of drug resistance are hard to decipher, and little is known at the metabolic level. Here we apply metabolomic profiling to discover meta...

journal_title：Journal of proteome research

authors： Li H,Xia X,Li X,Naren G,Fu Q,Wang Y,Wu C,Ding S,Zhang S,Jiang H,Li J,Shen J

更新日期：2015-02-06 00:00:00

abstract：:Campylobacter jejuni is the most common cause of bacterial gastroenteritis in the developed world. Immunoproteomics highlighted a 42-45 kDa antigen that comigrated on two-dimensional (2-DE) gels with the C. jejuni major outer membrane protein (MOMP). Predictive analysis revealed two candidates for the identity of the ...

journal_title：Journal of proteome research

authors： Scott NE,Bogema DR,Connolly AM,Falconer L,Djordjevic SP,Cordwell SJ

更新日期：2009-10-01 00:00:00

abstract：:Gastric cancer (GC) is among the most common cancers worldwide. Gastric carcinogenesis is a multistep and multifactorial process beginning with chronic gastritis induced by Helicobacter pylori (H. pylori) infection. This process is often described via a sequence of events known as Correas's cascade, a stepwise progres...

journal_title：Journal of proteome research

authors： Kuligowski J,Sanjuan-Herráez D,Vázquez-Sánchez MA,Brunet-Vega A,Pericay C,Ramírez-Lázaro MJ,Lario S,Gombau L,Junquera F,Calvet X,Quintás G

更新日期：2016-08-05 00:00:00

abstract：:Ceramides are central molecules in sphingolipid metabolism. They are involved in the regulation of cancer-cell growth, differentiation, senescence and apoptosis. To better understand how these secondary messengers induce their biological effects, adenocarcinoma cells (HCT116) were treated with exogenous long-chain cer...

journal_title：Journal of proteome research

authors： Rénert AF,Leprince P,Dieu M,Renaut J,Raes M,Bours V,Chapelle JP,Piette J,Merville MP,Fillet M

更新日期：2009-10-01 00:00:00

abstract：:Peptide amidination labeling using S-methyl thioacetimidate (SMTA) is investigated in an attempt to increase the number and types of peptides that can be detected in a bottom-up proteomics experiment. This derivatization method affects the basicity of lysine residues and is shown here to significantly impact the idios...

journal_title：Journal of proteome research

authors： Li S,Dabir A,Misal SA,Tang H,Radivojac P,Reilly JP

更新日期：2016-10-07 00:00:00

abstract：:Yellow fever virus (YFV) replication is highly dependent on host cell factors. YFV NS4B is reported to be involved in viral replication and immune evasion. Here interactions between NS4B and human proteins were determined using a GST pull-down assay and analyzed using 1-DE and LC-MS/MS. We present a total of 207 prote...

journal_title：Journal of proteome research

authors： Vidotto A,Morais AT,Ribeiro MR,Pacca CC,Terzian AC,Gil LH,Mohana-Borges R,Gallay P,Nogueira ML

更新日期：2017-04-07 00:00:00

abstract：:Clostridioides difficile-associated infection (CDI) is a health-care-associated infection caused, as the name suggests, by obligate anaerobic pathogen C. difficile and thus mainly transmitted via highly resistant endospores from one person to the other. In vivo, the spores need to germinate into cells prior to establi...

journal_title：Journal of proteome research

authors： Abhyankar WR,Zheng L,Brul S,de Koster CG,de Koning LJ

更新日期：2019-11-01 00:00:00

abstract：:The protein kinase AKT is a central kinase in the heart and has a major impact on growth/hypertrophy, survival/apoptosis, and metabolism. To gain more insight into AKT isoform-specific signaling at the molecular level, we investigated the phosphoproteome of HL-1 cardiomyocytes carrying AKT1 or AKT2 isoform-specific kn...

journal_title：Journal of proteome research

authors： Reinartz M,Raupach A,Kaisers W,Gödecke A

更新日期：2014-10-03 00:00:00

abstract：:The neurodegenerative disorder Alzheimer's disease (AD) is the most common cause of dementia in the elderly. The presence of neurofibrillary tangles, consisting of hyperphosphorylated tau protein, is one of the major neuropathologic characteristics of the disease, making this protein an attractive biomarker for AD and...

journal_title：Journal of proteome research

authors： Portelius E,Hansson SF,Tran AJ,Zetterberg H,Grognet P,Vanmechelen E,Höglund K,Brinkmalm G,Westman-Brinkmalm A,Nordhoff E,Blennow K,Gobom J

更新日期：2008-05-01 00:00:00

abstract：:Histones are well-conserved proteins that form the basic structure of chromatin in eukaryotes and undergo several post-translational modifications, which are important for the control of transcription, replication, DNA damage repair, and chromosome condensation. In early branched organisms, histones are less conserved...

journal_title：Journal of proteome research

authors： de Jesus TC,Nunes VS,Lopes Mde C,Martil DE,Iwai LK,Moretti NS,Machado FC,de Lima-Stein ML,Thiemann OH,Elias MC,Janzen C,Schenkman S,da Cunha JP

更新日期：2016-06-03 00:00:00

abstract：:To estimate the potential of the state-of-the-art proteomics technologies on full coverage of the encoding gene products, the Chinese Human Chromosome Proteome Consortium (CCPC) applied a multiomics strategy to systematically analyze the transciptome, translatome, and proteome of the same cultured hepatoma cells with ...

journal_title：Journal of proteome research

authors： Chang C,Li L,Zhang C,Wu S,Guo K,Zi J,Chen Z,Jiang J,Ma J,Yu Q,Fan F,Qin P,Han M,Su N,Chen T,Wang K,Zhai L,Zhang T,Ying W,Xu Z,Zhang Y,Liu Y,Liu X,Zhong F,Shen H,Wang Q,Hou G,Zhao H,Li G,Liu S,G

更新日期：2014-01-03 00:00:00

abstract：:RelA (NF-kappaB) is a transcription factor inducible by distinct stimuli in many different cell types. To find new cell type specific cofactors of NF-kappaB dependent transcription, we isolated RelA transcription activation domain binding proteins from the nuclear extracts of three different cell types. Analysis by el...

journal_title：Journal of proteome research

authors： Owen HR,Quadroni M,Bienvenut W,Buerki C,Hottiger MO

更新日期：2005-07-01 00:00:00

abstract：:In this study we selected three breast cancer cell lines (SKBR3, SUM149 and SUM190) with different oncogene expression levels involved in ERBB2 and EGFR signaling pathways as a model system for the evaluation of selective integration of subsets of transcriptomic and proteomic data. We assessed the oncogene status with...

journal_title：Journal of proteome research

authors： Zhang EY,Cristofanilli M,Robertson F,Reuben JM,Mu Z,Beavis RC,Im H,Snyder M,Hofree M,Ideker T,Omenn GS,Fanayan S,Jeong SK,Paik YK,Zhang AF,Wu SL,Hancock WS

更新日期：2013-06-07 00:00:00

abstract：:The Biology/Disease-driven (B/D) working groups of the Human Proteome Project are alliances of research groups aimed at developing or improving proteomic tools to support specific biological or disease-related research areas. Here, we describe the activities and progress to date of the B/D working group focused on pro...

journal_title：Journal of proteome research

authors： Boersema PJ,Melnik A,Hazenberg BPC,Rezeli M,Marko-Varga G,Kamiie J,Portelius E,Blennow K,Zubarev RA,Polymenidou M,Picotti P

更新日期：2018-12-07 00:00:00

abstract：:The ThinPrep cervical smear is widely used in clinical practice for the cytological and molecular screening against abnormal cells and Human Papillomavirus (HPV) infection. Current advancements made to LC-MS proteomics include the use of stable isotope labeling for the in-depth analysis of proteins in complex clinical...

journal_title：Journal of proteome research

authors： Papachristou EK,Roumeliotis TI,Chrysagi A,Trigoni C,Charvalos E,Townsend PA,Pavlakis K,Garbis SD

更新日期：2013-05-03 00:00:00

abstract：:Breast cancer is a leading cancer in women and is considered to be the second-most common metastatic cancer following lung cancer. An estimated 10-16% of breast cancer patients are suffering from brain metastasis, and the diagnostic cases of breast cancer brain metastasis are increasing. Nevertheless, the mechanisms b...

journal_title：Journal of proteome research

authors： Peng W,Goli M,Mirzaei P,Mechref Y

更新日期：2019-10-04 00:00:00

abstract：:Stress in the form of moderate periods of maternal separation of newborn rats has been postulated to cause permanent changes in the central nervous system and diseases in later life. It is also considered that dietary supplementation with long chain polyunsaturated fatty acids (LC-PUFAs) can potentially ameliorate the...

journal_title：Journal of proteome research

authors： Wang Y,Holmes E,Tang H,Lindon JC,Sprenger N,Turini ME,Bergonzelli G,Fay LB,Kochhar S,Nicholson JK

更新日期：2006-07-01 00:00:00

abstract：:Acute stress may trigger systemic biochemical and physiological changes in living organisms, leading to a rapid loss of homeostasis, which can be gradually reinstated by self-regulatory mechanisms and/or drug intervention strategy. However, such a sophisticated metabolic regulatory process has so far been poorly under...

journal_title：Journal of proteome research

authors： Wang X,Su M,Qiu Y,Ni Y,Zhao T,Zhou M,Zhao A,Yang S,Zhao L,Jia W

更新日期：2007-09-01 00:00:00