Abstract：
:Gastric cancer (GC) is among the most common cancers worldwide. Gastric carcinogenesis is a multistep and multifactorial process beginning with chronic gastritis induced by Helicobacter pylori (H. pylori) infection. This process is often described via a sequence of events known as Correas's cascade, a stepwise progression from nonactive gastritis, chronic active gastritis, precursor lesions of gastric cancer (atrophy, intestinal metaplasia, and dysplasia), and finally adenocarcinoma. Our aim was to identify a plasma metabolic pattern characteristic of GC through disease progression within the Correa's cascade. This study involved the analysis of plasma samples collected from 143 patients classified in four groups: patients with nonactive gastritis and no H. pylori infection, H. pylori infected patients with chronic active gastritis, infected or noninfected patients with precursor lesions of gastric cancer, and GC. Independent partial least-squares-discriminant binary models of UPLC-ESI(+)-TOFMS metabolic profiles, implemented in a decision-directed acyclic graph, allowed the identification of tryptophan and kynurenine as discriminant metabolites that could be attributed to indoleamine-2,3-dioxygenase upregulation in cancer patients leading to tryptophan depletion and kynurenine metabolites generation. Furthermore, phenylacetylglutamine was also classified as a discriminant metabolite. Our data suggest the use of tryptophan, kynurenine, and phenylacetylglutamine as potential GC biomarkers.
journal_name
J Proteome Resjournal_title
Journal of proteome researchauthors
Kuligowski J,Sanjuan-Herráez D,Vázquez-Sánchez MA,Brunet-Vega A,Pericay C,Ramírez-Lázaro MJ,Lario S,Gombau L,Junquera F,Calvet X,Quintás Gdoi
10.1021/acs.jproteome.6b00281subject
Has Abstractpub_date
2016-08-05 00:00:00pages
2729-38issue
8eissn
1535-3893issn
1535-3907journal_volume
15pub_type
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journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2007-02-01 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2013-08-02 00:00:00
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journal_title：Journal of proteome research
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journal_title：Journal of proteome research
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journal_title：Journal of proteome research
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journal_title：Journal of proteome research
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journal_title：Journal of proteome research
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更新日期：2015-11-06 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
doi：10.1021/acs.jproteome.6b00828
更新日期：2017-02-03 00:00:00
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journal_title：Journal of proteome research
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更新日期：2008-04-01 00:00:00
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journal_title：Journal of proteome research
pub_type： 杂志文章
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更新日期：2011-08-05 00:00:00
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更新日期：2010-11-05 00:00:00
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doi：10.1021/pr400583h
更新日期：2013-12-06 00:00:00
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journal_title：Journal of proteome research
pub_type： 评论,杂志文章
doi：10.1021/pr070315e
更新日期：2007-09-01 00:00:00
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journal_title：Journal of proteome research
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更新日期：2012-07-06 00:00:00
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journal_title：Journal of proteome research
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更新日期：2018-12-07 00:00:00
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