当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats.

Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats.

Abstract：

:In salt-sensitive hypertension, reactive oxygen species (ROS) play a major role in the progression of renal disease partly through the activation of the mineralocorticoid receptor (MR). We have previously demonstrated that urinary vanin-1 is an early biomarker of oxidative renal tubular injury. However, it remains unknown whether urinary vanin-1 might reflect the treatment effect. The objective of this study was to clarify the treatment effect for renal tubular damage in Dahl salt-sensitive (DS) rats. DS rats (six weeks old) were given one of the following for four weeks: high-salt diet (8% NaCl), high-salt diet plus a superoxide dismutase mimetic, tempol (3 mmol/L in drinking water), high-salt diet plus eplerenone (100 mg/kg/day), and normal-salt diet (0.3% NaCl). After four-week treatment, blood pressure was measured and kidney tissues were evaluated. ROS were assessed by measurements of malondialdehyde and by immunostaining for 4-hydroxy-2-nonenal. A high-salt intake for four weeks caused ROS and histological renal tubular damages in DS rats, both of which were suppressed by tempol and eplerenone. Proteinuria and urinary N-acetyl-β-D-glucosaminidase exhibited a significant decrease in DS rats receiving a high-salt diet plus eplerenone, but not tempol. In contrast, urinary vanin-1 significantly decreased in DS rats receiving a high-salt diet plus eplerenone as well as tempol. Consistent with these findings, immunohistochemical analysis revealed that vanin-1 was localized in the renal proximal tubules but not the glomeruli in DS rats receiving a high-salt diet, with the strength attenuated by tempol or eplerenone treatment. In conclusion, these results suggest that urinary vanin-1 is a potentially sensitive biomarker for ameliorating renal tubular damage in salt-sensitive hypertension.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Hosohata K,Jin D,Takai S,Iwanaga K

doi

10.3390/ijms20184481

subject

Has Abstract

pub_date

2019-09-11 00:00:00

issue

18

issn

1422-0067

pii

ijms20184481

journal_volume

20

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Diverse roles of SIRT1 in cancer biology and lipid metabolism.

    abstract：:SIRT1, an NAD(+)-dependent deacetylase, has been described in the literature as a major player in the regulation of cellular stress responses. Its expression has been shown to be altered in cancer cells, and it targets both histone and non-histone proteins for deacetylation and thereby alters metabolic programs in res...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms16010950

    authors： Simmons GE Jr,Pruitt WM,Pruitt K

    更新日期：2015-01-05 00:00:00

  • Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders.

    abstract：:In clinical practice, the metabolic syndrome can lead to multiple complications, including diabetes. It remains unclear which component of the metabolic syndrome (obesity, inflammation, hyperglycemia, or insulin resistance) has the strongest inhibitory effect on stem cells involved in beta cell regeneration. This make...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21030991

    authors： Vladimirovna Pakhomova A,Nebolsin VE,Victorovna Pershina O,Andreevich Krupin V,Alexandrovna Sandrikina L,Sergeevich Pan E,Nicolaevna Ermakova N,Evgenevna Vaizova O,Widera D,Grimm WD,Yur'evich Kravtsov V,Alexandrovich Afanasiev S,

    更新日期：2020-02-03 00:00:00

  • Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats.

    abstract：:Cardamom is a popular spice that has been commonly used in cuisines for flavor since ancient times. It has copious health benefits such as improving digestion, stimulating metabolism, and exhibits antioxidant and anti-inflammatory effects. The current study investigated the effect of cardamom on hemodynamic, biochemic...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms161126040

    authors： Goyal SN,Sharma C,Mahajan UB,Patil CR,Agrawal YO,Kumari S,Arya DS,Ojha S

    更新日期：2015-11-17 00:00:00

  • The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug Disposition.

    abstract：:A considerable number of drugs and/or their metabolites are excreted by the kidneys through glomerular filtration and active renal tubule secretion via transporter proteins. Uptake transporters in the proximal tubule are part of the solute carrier (SLC) superfamily, and include the organic cation transporters (OCTs). ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21186627

    authors： Zazuli Z,Duin NJCB,Jansen K,Vijverberg SJH,Maitland-van der Zee AH,Masereeuw R

    更新日期：2020-09-10 00:00:00

  • Contribution of Palmitic Acid to Epidermal Morphogenesis and Lipid Barrier Formation in Human Skin Equivalents.

    abstract：:The outermost barrier layer of the skin is the stratum corneum (SC), which consists of corneocytes embedded in a lipid matrix. Biosynthesis of barrier lipids occurs de novo in the epidermis or is performed with externally derived lipids. Hence, in vitro developed human skin equivalents (HSEs) are developed with cultur...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20236069

    authors： Mieremet A,Helder R,Nadaban A,Gooris G,Boiten W,El Ghalbzouri A,Bouwstra JA

    更新日期：2019-12-02 00:00:00

  • Synthesis and Evaluation of Neuroprotective Selenoflavanones.

    abstract：:The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestiv...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms161226188

    authors： Choi YS,Kim DM,Kim YJ,Yang S,Lee KT,Ryu JH,Jeong JH

    更新日期：2015-12-10 00:00:00

  • Acute Toxicity-Supported Chronic Toxicity Prediction: A k-Nearest Neighbor Coupled Read-Across Strategy.

    abstract：:A k-nearest neighbor (k-NN) classification model was constructed for 118 RDT NEDO (Repeated Dose Toxicity New Energy and industrial technology Development Organization; currently known as the Hazard Evaluation Support System (HESS)) database chemicals, employing two acute toxicity (LD50)-based classes as a response an...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms160511659

    authors： Chavan S,Friedman R,Nicholls IA

    更新日期：2015-05-21 00:00:00

  • Surface Modification of PLLA, PTFE and PVDF with Extreme Ultraviolet (EUV) to Enhance Cell Adhesion.

    abstract：:Recently, extreme ultraviolet (EUV) radiation has been increasingly used to modify polymers. Properties such as the extremely short absorption lengths in polymers and the very strong interaction of EUV photons with materials may play a key role in achieving new biomaterials. The purpose of the study was to examine the...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21249679

    authors： Lech A,Butruk-Raszeja BA,Ciach T,Lawniczak-Jablonska K,Kuzmiuk P,Bartnik A,Wachulak P,Fiedorowicz H

    更新日期：2020-12-18 00:00:00

  • Novel Potassium Channels in Kidney Mitochondria: The Hyperpolarization-Activated and Cyclic Nucleotide-Gated HCN Channels.

    abstract：:Hyperpolarization-activated cationic HCN channels comprise four members (HCN1-4) that control dendritic integration, synaptic transmission and action potential firing. In the kidney, HCN1, HCN2 and HCN3 are differentially expressed and contribute to the transport of sodium, potassium (K+) and ammonium into the nephron...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20204995

    authors： León-Aparicio D,Salvador C,Aparicio-Trejo OE,Briones-Herrera A,Pedraza-Chaverri J,Vaca L,Sampieri A,Padilla-Flores T,López-González Z,León-Contreras JC,Hernández-Pando R,Escobar LI

    更新日期：2019-10-09 00:00:00

  • In Silico Finding of Key Interaction Mediated α3β4 and α7 Nicotinic Acetylcholine Receptor Ligand Selectivity of Quinuclidine-Triazole Chemotype.

    abstract：:The selective binding of six (S)-quinuclidine-triazoles and their (R)-enantiomers to nicotinic acetylcholine receptor (nAChR) subtypes α3β4 and α7, respectively, were analyzed by in silico docking to provide the insight into the molecular basis for the observed stereospecific subtype discrimination. Homology modeling ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21176189

    authors： Arunrungvichian K,Chongruchiroj S,Sarasamkan J,Schüürmann G,Brust P,Vajragupta O

    更新日期：2020-08-27 00:00:00

  • Colistin Dependence in Extensively Drug-Resistant Acinetobacter baumannii Strain Is Associated with ISAjo2 and ISAba13 Insertions and Multiple Cellular Responses.

    abstract：:The nosocomial opportunistic Gram-negative bacterial pathogen Acinetobacter baumannii is resistant to multiple antimicrobial agents and an emerging global health problem. The polymyxin antibiotic colistin, targeting the negatively charged lipid A component of the lipopolysaccharide on the bacterial cell surface, is of...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22020576

    authors： Chamoun S,Welander J,Martis-Thiele MM,Ntzouni M,Claesson C,Vikström E,Turkina MV

    更新日期：2021-01-08 00:00:00

  • 3D-Reconstructed Retinal Pigment Epithelial Cells Provide Insights into the Anatomy of the Outer Retina.

    abstract：:The retinal pigment epithelium (RPE) is located between the neuroretina and the choroid, and plays a critical role in vision. RPE cells internalise outer segments (OS) from overlying photoreceptors in the daily photoreceptor renewal. Changes to RPE structure are linked with age and retinopathy, which has been describe...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21218408

    authors： Keeling E,Chatelet DS,Tan NYT,Khan F,Richards R,Thisainathan T,Goggin P,Page A,Tumbarello DA,Lotery AJ,Ratnayaka JA

    更新日期：2020-11-09 00:00:00

  • Mechanotransduction and Cytoskeleton Remodeling Shaping YAP1 in Gastric Tumorigenesis.

    abstract：:The essential role of Hippo signaling pathway in cancer development has been elucidated by recent studies. In the gastrointestinal tissues, deregulation of the Hippo pathway is one of the most important driving events for tumorigenesis. It is widely known that Yes-associated protein 1 (YAP1) and WW domain that contain...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20071576

    authors： Zhang J,Zhou Y,Tang PMK,Cheng ASL,Yu J,To KF,Kang W

    更新日期：2019-03-29 00:00:00

  • Absence of Nuclear p16 Is a Diagnostic and Independent Prognostic Biomarker in Squamous Cell Carcinoma of the Cervix.

    abstract：:The tumor-suppressor protein p16 is paradoxically overexpressed in cervical cancer (CC). Despite its potential as a biomarker, its clinical value and the reasons for its failure in tumor suppression remain unclear. Our purpose was to determine p16 clinical and biological significance in CC. p16 expression pattern was ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21062125

    authors： Mendaza S,Fernández-Irigoyen J,Santamaría E,Zudaire T,Guarch R,Guerrero-Setas D,Vidal A,Santos-Salas J,Matias-Guiu X,Ausín K,Díaz de Cerio MJ,Martín-Sánchez E

    更新日期：2020-03-19 00:00:00

  • Aedes albopictus Autophagy-Related Gene 8 (AaAtg8) Is Required to Confer Anti-Bacterial Gut Immunity.

    abstract：:Autophagy is an important process by which pathogens and damaged or unused organelles are eliminated. The role of autophagy in development and the immune response to pathogens is well established. Autophagy-related protein 8 (Atg8) is involved in the formation of the autophagosome and, with the help of the serine prot...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21082944

    authors： Kim CE,Park KB,Ko HJ,Keshavarz M,Bae YM,Kim B,Patnaik BB,Jang HA,Lee YS,Han YS,Jo YH

    更新日期：2020-04-22 00:00:00

  • What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?

    abstract：:Over the years of evolution, thousands of different animal species have evolved. All these species require an immune system to defend themselves against invading pathogens. Nevertheless, the immune systems of different species are obviously counteracting against the same pathogen with different efficiency. Therefore, ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21124523

    authors： Fingerhut L,Dolz G,de Buhr N

    更新日期：2020-06-25 00:00:00

  • Quantitative expression of C-type lectin receptors in humans and mice.

    abstract：:C-type lectin receptors and their adaptor molecules are involved in the recognition of glycosylated self-antigens and pathogens. However, little is known about the species- and organ-specific expression profiles of these molecules. We therefore determined the mRNA expression levels of Dectin-1, MR1, MR2, DC-SIGN, Syk,...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms130810113

    authors： Lech M,Susanti HE,Römmele C,Gröbmayr R,Günthner R,Anders HJ

    更新日期：2012-01-01 00:00:00

  • Analysis of the Effect of Increased α2,3-Sialylation on RTK Activation in MKN45 Gastric Cancer Spheroids Treated with Crizotinib.

    abstract：:In the scenario of personalized medicine, targeted therapies are currently the focus of cancer drug development. These drugs can block the growth and spread of tumor cells by interfering with key molecules involved in malignancy, such as receptor tyrosine kinases (RTKs). MET and Recepteur d'Origine Nantais (RON), whic...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21030722

    authors： Balmaña M,Diniz F,Feijão T,Barrias CC,Mereiter S,Reis CA

    更新日期：2020-01-22 00:00:00

  • Increased ROS Scavenging and Antioxidant Efficiency of Chlorogenic Acid Compound Delivered via a Chitosan Nanoparticulate System for Efficient In Vitro Visualization and Accumulation in Human Renal Adenocarcinoma Cells.

    abstract：:Naturally existing Chlorogenic acid (CGA) is an antioxidant-rich compound reported to act a chemopreventive agent by scavenging free radicals and suppressing cancer-causing mechanisms. Conversely, the compound's poor thermal and pH (neutral and basic) stability, poor solubility, and low cellular permeability have been...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20194667

    authors： Kavi Rajan R,Hussein MZ,Fakurazi S,Yusoff K,Masarudin MJ

    更新日期：2019-09-20 00:00:00

  • The Possible Importance of β3 Integrins for Leukemogenesis and Chemoresistance in Acute Myeloid Leukemia.

    abstract：:Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy where the immature leukemia cells communicate with neighboring cells through constitutive cytokine release and through their cell surface adhesion molecules. The primary AML cells express various integrins. These heterodimeric molecules containing an...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19010251

    authors： Johansen S,Brenner AK,Bartaula-Brevik S,Reikvam H,Bruserud Ø

    更新日期：2018-01-15 00:00:00

  • miR-206-3p Inhibits 3T3-L1 Cell Adipogenesis via the c-Met/PI3K/Akt Pathway.

    abstract：:MicroRNAs (miRNAs) are important post-transcriptional regulators during adipocyte adipogenesis. MiR-206-3p, a tissue-specific miRNA, is absent in white adipocytes. In this study, we examined the roles of mmu-miR-206-3p in the adipogenic differentiation of 3T3-L1 preadipocytes. The miR-206-3p expression has shown an ap...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18071510

    authors： Tang R,Ma F,Li W,Ouyang S,Liu Z,Wu J

    更新日期：2017-07-14 00:00:00

  • Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation.

    abstract：:A key role of the mitochondrial Translocator Protein 18 KDa (TSPO) in neuroinflammation has been recently proposed. However, little is known about TSPO-activated pathways underlying the modulation of reactive microglia. In the present work, the TSPO activation was explored in an in vitro human primary microglia model ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20184467

    authors： Pozzo ED,Tremolanti C,Costa B,Giacomelli C,Milenkovic VM,Bader S,Wetzel CH,Rupprecht R,Taliani S,Settimo FD,Martini C

    更新日期：2019-09-10 00:00:00

  • Cytoprotective Effect of the UCP2-SIRT3 Signaling Pathway by Decreasing Mitochondrial Oxidative Stress on Cerebral Ischemia-Reperfusion Injury.

    abstract：:Recovered blood supply after cerebral ischemia for a certain period of time fails to restore brain function, with more severe dysfunctional problems developing, called cerebral ischemia-reperfusion injury (CIR). CIR involves several extremely complex pathophysiological processes in which the interactions between key f...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18071599

    authors： Su J,Liu J,Yan XY,Zhang Y,Zhang JJ,Zhang LC,Sun LK

    更新日期：2017-07-24 00:00:00

  • TGF-β Signaling and the Epithelial-Mesenchymal Transition during Palatal Fusion.

    abstract：:Signaling by transforming growth factor (TGF)-β plays an important role in development, including in palatogenesis. The dynamic morphological process of palatal fusion occurs to achieve separation of the nasal and oral cavities. Critically and specifically important in palatal fusion are the medial edge epithelial (ME...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19113638

    authors： Nakajima A,F Shuler C,Gulka AOD,Hanai JI

    更新日期：2018-11-19 00:00:00

  • Impact of Chronic Hepatitis C Virus Genotype 1b Infection on Triglyceride Concentration in Serum Lipoprotein Fractions.

    abstract：:Reduced low-density lipoprotein (LDL) cholesterol level is a characteristic feature of dyslipidemia in chronic hepatitis C virus (HCV) infection. However, abnormality in serum triglyceride (TG) has not been fully investigated. To clarify the impact of HCV genotype 1b (G1b) infection and advanced fibrosis on serum TG p...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms160920576

    authors： Nagano T,Seki N,Tomita Y,Sugita T,Aida Y,Itagaki M,Sutoh S,Abe H,Tsubota A,Aizawa Y

    更新日期：2015-08-31 00:00:00

  • Variations in IC(50) values with purity of mushroom tyrosinase.

    abstract：:The effects of various inhibitors on crude, commercial and partially purified commercial mushroom tyrosinase were examined by comparing IC(50) values. Kojic acid, salicylhydroxamic acid, tropolone, methimazole, and ammonium tetrathiomolybdate had relatively similar IC(50) values for the crude, commercial and partially...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms10093811

    authors： Neeley E,Fritch G,Fuller A,Wolfe J,Wright J,Flurkey W

    更新日期：2009-09-02 00:00:00

  • Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research.

    abstract：:Growing evidence supports a role of vitamin D (VD) in reproductive health. Vitamin D receptor (VDR) is expressed in the ovary, endometrium, and myometrium. The biological actions of VD in fertility and reproductive tissues have been investigated but mainly using animal models. Conversely, the molecular data addressing...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19082320

    authors： Cermisoni GC,Alteri A,Corti L,Rabellotti E,Papaleo E,Viganò P,Sanchez AM

    更新日期：2018-08-08 00:00:00

  • The Role of Cyclo(His-Pro) in Neurodegeneration.

    abstract：:Neurodegenerative diseases may have distinct genetic etiologies and pathological manifestations, yet share common cellular mechanisms underpinning neuronal damage and dysfunction. These cellular mechanisms include excitotoxicity, calcium dysregulation, oxidative damage, ER stress and neuroinflammation. Recent data hav...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms17081332

    authors： Grottelli S,Ferrari I,Pietrini G,Peirce MJ,Minelli A,Bellezza I

    更新日期：2016-08-12 00:00:00

  • Inhibition of oxidative stress by low-molecular-weight polysaccharides with various functional groups in skin fibroblasts.

    abstract：:The aim of this study was to evaluate the in cellulo inhibition of hydrogen-peroxide-induced oxidative stress in skin fibroblasts using different low-molecular-weight polysaccharides (LMPS) prepared from agar (LMAG), chitosan (LMCH) and starch (LMST), which contain various different functional groups (i.e., sulfate, a...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms141019399

    authors： Chen SK,Hsu CH,Tsai ML,Chen RH,Drummen GP

    更新日期：2013-09-25 00:00:00

  • Chemical Profile and Antioxidant, Anti-Inflammatory, Antimutagenic and Antimicrobial Activities of Geopropolis from the Stingless Bee Melipona orbignyi.

    abstract：:Geopropolis is a resin mixed with mud, produced only by stingless bees. Despite being popularly known for its medicinal properties, few scientific studies have proven its biological activities. In this context, the objective of this study was to determine the chemical composition and antioxidant, anti-inflammatory, an...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms18050953

    authors： Santos HFD,Campos JF,Santos CMD,Balestieri JBP,Silva DB,Carollo CA,de Picoli Souza K,Estevinho LM,Dos Santos EL

    更新日期：2017-05-03 00:00:00