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Inhibition of oxidative stress by low-molecular-weight polysaccharides with various functional groups in skin fibroblasts.

Abstract：

:The aim of this study was to evaluate the in cellulo inhibition of hydrogen-peroxide-induced oxidative stress in skin fibroblasts using different low-molecular-weight polysaccharides (LMPS) prepared from agar (LMAG), chitosan (LMCH) and starch (LMST), which contain various different functional groups (i.e., sulfate, amine, and hydroxyl groups). The following parameters were evaluated: cell viability, intracellular oxidant production, lipid peroxidation, and DNA damage. Trolox was used as a positive control in order to allow comparison of the antioxidant efficacies of the various LMPS. The experimentally determined attenuation of oxidative stress by LMPS in skin fibroblasts was: LMCH > LMAG > LMST. The different protection levels of these LMPS may be due to the physic-chemical properties of the LMPS' functional groups, including electron transfer ability, metal ion chelating capacities, radical stabilizing capacity, and the hydrophobicity of the constituent sugars. The results suggest that LMCH might constitute a novel and potential dermal therapeutic and sun-protective agent.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Chen SK,Hsu CH,Tsai ML,Chen RH,Drummen GP

doi

10.3390/ijms141019399

subject

Has Abstract

pub_date

2013-09-25 00:00:00

pages

19399-415

issue

10

issn

1422-0067

pii

ijms141019399

journal_volume

14

pub_type

杂志文章

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