Abstract：
:A considerable number of drugs and/or their metabolites are excreted by the kidneys through glomerular filtration and active renal tubule secretion via transporter proteins. Uptake transporters in the proximal tubule are part of the solute carrier (SLC) superfamily, and include the organic cation transporters (OCTs). Several studies have shown that specific genetic polymorphisms in OCTs alter drug disposition and may lead to nephrotoxicity. Multiple single nucleotide polymorphisms (SNPs) have been reported for the OCT genes (SLC22A1, SLC22A2 and SLC22A3), which can influence the proteins' structure and expression levels and affect their transport function. A gain-in-function mutation may lead to accumulation of drugs in renal proximal tubule cells, eventually leading to nephrotoxicity. This review illustrates the impact of genetic polymorphisms in OCTs on renal drug disposition and kidney injury, the clinical significances and how to personalize therapies to minimize the risk of drug toxicity.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Zazuli Z,Duin NJCB,Jansen K,Vijverberg SJH,Maitland-van der Zee AH,Masereeuw Rdoi
10.3390/ijms21186627subject
Has Abstractpub_date
2020-09-10 00:00:00issue
18issn
1422-0067pii
ijms21186627journal_volume
21pub_type
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