Abstract:
:The physicochemical properties and antioxidant activity of a molecule could be improved by the substitution of an oxygen atom in a molecule with selenium. We synthesized selenoflavanones and flavanones to evaluate their neuroprotective effects. The selenoflavanones showed improved physicochemical properties, suggestive of the ability to pass through the blood-brain barrier (BBB). They showed in vitro antioxidant effects against hydrogen peroxide, and did not result in severe cytotoxicity. Moreover, infarction volumes in a transient ischemia mouse model were significantly reduced by the selenoflavanone treatments.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Choi YS,Kim DM,Kim YJ,Yang S,Lee KT,Ryu JH,Jeong JHdoi
10.3390/ijms161226188subject
Has Abstractpub_date
2015-12-10 00:00:00pages
29574-82issue
12issn
1422-0067pii
ijms161226188journal_volume
16pub_type
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