A high-salt diet aggravates retinal ischaemia/reperfusion injury.

abstract：:We have examined the possible expression of fibroblast growth factor in cultured cells derived from bovine lens epithelium and corneal endothelium. Lens epithelial, but not corneal endothelial, cells were found to express the acidic fibroblast growth factor (aFGF) gene, whereas both cell types express the gene encodin...

journal_title：Experimental eye research

authors： Schweigerer L,Ferrara N,Haaparanta T,Neufeld G,Gospodarowicz D

更新日期：1988-01-01 00:00:00

abstract：:The purpose of this study was to investigate the impact of different diffusion times of mitomycin-C (MMC) on the intrascleral concentration vs depth profile of MMC in an experimental model. Scleral quadrants of eight human donor eyes were exposed to sponges soaked with MMC for an application time of 1 min. After irrig...

journal_title：Experimental eye research

authors： Georgopoulos M,Vass C,El Menyawi I,Radda S,Graninger W,Menapace R

更新日期：2000-11-01 00:00:00

abstract：:Mice carrying the rd mutation are affected with an autosomal recessive disease characterized by the total degeneration of retinal photoreceptor cells, which begins at postnatal day 8 and reaches completion by 3 wk of life. Biochemical studies have led to the proposal that a lesion in cGMP metabolism may be the cause o...

journal_title：Experimental eye research

authors： Danciger M,Tuteja N,Kozak CA,Farber DB

更新日期：1989-02-01 00:00:00

abstract：:Interphotoreceptor retinoid-binding protein (IRBP) is a vitamin A carrier present only in the extracellular material lying between the neural retina and the retinal pigment epithelium of vertebrate eyes. The amount of retinol bound endogenously by IRBP in this interphotoreceptor space is known to increase upon illumin...

journal_title：Experimental eye research

authors： Adler AJ,Spencer SA

更新日期：1991-09-01 00:00:00

abstract：:Metabolic disturbances in diabetes mellitus include changes in the type and concentration of lipids in the blood plasma which may contribute to the development of diabetic retinopathy. This disease is characterized by changes in retinal blood flow secondary to changes in the tone of retinal arterioles which is regulat...

journal_title：Experimental eye research

authors： Bek T,Al-Mashhadi RH,Misfeldt M,Riis-Vestergaard MJ,Bentzon JF,Pedersen SM

更新日期：2013-10-01 00:00:00

abstract：:The R49C mutation of alphaA-crystallin (alphaA-R49C) causes hereditary cataracts in humans; patients in a four-generation Caucasian family were found be heterozygous for this autosomal dominant mutation. We previously generated knock-in mouse models of this mutation and found that by 2 months of age, heterozygous muta...

journal_title：Experimental eye research

authors： Andley UP,Reilly MA

更新日期：2010-06-01 00:00:00

abstract：:Prolyl oligopeptidase (EC 3.4.21.26) has been purified 26,000-fold from bovine lens tissue by anion-exchange chromatography, gel filtration and isoelectric focussing, with an overall yield of 11%. The purified enzyme exhibited an isoelectric point of 4.8, a pH optimum of 7.5 and a molecular mass of 72 kDa under both n...

journal_title：Experimental eye research

authors： Sharma KK,Ortwerth BJ

更新日期：1994-07-01 00:00:00

abstract：:The objective of this study was to compare the efficiency of various formulations in maximizing the ratio of ocular to systemic absorption of topically applied timolol in the pigmented rabbit. Formulations of various pHs, tonicities, and concentrations of benzalkonium chloride, EDTA, poly(vinyl alcohol), poly(vinylpyr...

journal_title：Experimental eye research

authors： Podder SK,Moy KC,Lee VH

更新日期：1992-05-01 00:00:00

abstract：:The irritative response to Nd:YAG laser capsulotomy was studied in unanaesthetized rabbits. Posterior lens capsulotomy with a total energy of 100 mJ had no effect on the pupil size but increased the intraocular pressure by 5-10 mmHg and caused a breakdown of the blood-aqueous barrier. Anterior lens capsulotomy with a ...

journal_title：Experimental eye research

authors： Stjernschantz J,von Dickhoff K,Oksala O,Seppä H

更新日期：1986-10-01 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is a multifunctional matrix protein that has recently been examined in various wound processes, primarily for its ability to activate the latent complex of transforming growth factor-beta (TGF-β). TGF-β has been shown to play a major role in stimulating mesenchymal cells to synthesize extracel...

journal_title：Experimental eye research

authors： Matsuba M,Hutcheon AE,Zieske JD

更新日期：2011-10-01 00:00:00

abstract：:Monkey eyes are useful for ophthalmologic research into eye diseases because their histological and functional properties are very similar to those of humans. The monkey laser-induced high intraocular pressure (IOP) model is a common model for ophthalmologic research, especially into glaucoma. Although several studies...

journal_title：Experimental eye research

authors： Sasaoka M,Nakamura K,Shimazawa M,Ito Y,Araie M,Hara H

更新日期：2008-05-01 00:00:00

abstract：:SPARC (secreted protein acidic and rich in cysteine) is a matricellular protein that regulates cellular adhesion and proliferation. In this report, we show that SPARC protein is restricted to epithelial cells of the murine lens and ends abruptly at the equatorial bow region where lens fiber differentiation begins. SPA...

journal_title：Experimental eye research

authors： Bassuk JA,Birkebak T,Rothmier JD,Clark JM,Bradshaw A,Muchowski PJ,Howe CC,Clark JI,Sage EH

更新日期：1999-03-01 00:00:00

abstract：:Phosducin is a retinal and pineal phosphoprotein assumed to play an important role in visual phototransduction. Phosducin is also a uveitopathogenic retinal antigen, but its potency has been reported to be mild. During the course of studies aimed at identifying uveitopathogenic sites in phosducin, we found that rat ph...

journal_title：Experimental eye research

authors： Abe T,Satoh N,Nakajima A,Koizumi T,Tamada M,Sakuragi S

更新日期：1997-11-01 00:00:00

abstract：:Glaucoma is a leading cause of irreversible blindness worldwide. Lowering intraocular pressure (IOP) is the only strategy documented to delay the appearance and retard the progression of vision loss. One major approach for lowering IOP is to slow the rate of aqueous humor formation by the ciliary epithelium. As discus...

journal_title：Experimental eye research

authors： Do CW,Civan MM

更新日期：2009-04-01 00:00:00

abstract：:Anatomic and physiological barriers limit drug delivery to the posterior segment of the eye via topical or systemic administration. Intravitreal administration has proven to be a safe and effective means of treating various posterior segment diseases. Elimination of a compound from the vitreous chamber may depend on l...

journal_title：Experimental eye research

authors： Atluri H,Mitra AK

更新日期：2003-03-01 00:00:00

abstract：:The goal of this study was to investigate the efflux of K(+) from human corneal limbal epithelial cells (HCLE) exposed to ambient levels of UVB, which is known to cause apoptosis, and to examine the effect of K(+) channel blockers on loss of potassium induced by UVB. HCLE cells were exposed to 100-200 mJ/cm(2) UVB, fo...

journal_title：Experimental eye research

authors： Ubels JL,Van Dyken RE,Louters JR,Schotanus MP,Haarsma LD

更新日期：2011-05-01 00:00:00

abstract：:microPx-11, a ferriheme undecapeptide proteolytic degradation product of cytochrome C is shown to be a peroxidase with broad specificity degrading H2O2 and tertiary butyl hydroperoxide. It is also capable of effectively eliminating superoxide and hydroxyl radical. The peroxidase loses activity in the presence of perox...

journal_title：Experimental eye research

authors： Spector A,Ma W,Wang RR,Kleiman NJ

更新日期：1997-10-01 00:00:00

abstract：:We have reported that the aspartyl (Asp)-151 residue in alphaA-crystallin in human eye lens was inverted to the D-isomer and isomerized to beta-Asp residue with age. We report here that ultraviolet (UV)-B irradiation induces the racemization and isomerization of the Asp-151 residue of alphaA-crystallin from lenses of ...

journal_title：Experimental eye research

authors： Fujii N,Momose Y,Ishibashi Y,Uemura T,Takita M,Takehana M

更新日期：1997-07-01 00:00:00

abstract：:This study investigated the changes in pH during retinal artery occlusion by means of extracellular H+ concentration ([H+]o) measurements in the retina under both air and 100% O2 ventilation. Occlusion was produced in intact anesthetised cats by pressing with a probe onto a retinal artery. [H+]o profiles were recorded...

journal_title：Experimental eye research

authors： Birol G,Budzynski E,Wangsa-Wirawan ND,Linsenmeier RA

更新日期：2005-04-01 00:00:00

abstract：:The binding of eight fluorescence-labeled lectins to the photoreceptors of the monkey retina was investigated using a post-embedding staining method. Concanavalin A (specific for mannosyl and glucosyl residues) bound to the outer and inner segments of both rods and cones, while the degree of staining was more intense ...

journal_title：Experimental eye research

authors： Uehara F,Sameshima M,Muramatsu T,Ohba N

更新日期：1983-01-01 00:00:00

abstract：:Elevated permeability of retinal endothelial cells (REC), as observed in diabetic retinopathy (DR), is induced by extended exposure to ≥25 ng/ml vascular endothelial growth factor A165 (VEGF165) for up to 3 d and this effect is more pronounced when equimolar amounts of basic fibroblast growth factor (bFGF) and insulin...

journal_title：Experimental eye research

authors： Deissler HL,Deissler H,Lang GK,Lang GE

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:The feasibility of corneal reconstruction with cultured adult human corneal endothelial cells (HCEC) was examined in a nude rat model. METHODS:Endothelial cells were removed from the corneas of Lewis rats using a sterile cotton swab. Cultured adult HCEC labelled with a fluorescent marker chloromethyl-benzamido...

journal_title：Experimental eye research

authors： Mimura T,Amano S,Usui T,Araie M,Ono K,Akihiro H,Yokoo S,Yamagami S

更新日期：2004-08-01 00:00:00

abstract：:Rifampicin, an antibacterial drug widely used in the treatment of tuberculosis and leprosy, has recently been reported to have anti-oxidative and anti-apoptotic effects. However, its anti-angiogenic effect has not been investigated. We examined its anti-angiogenic effect on tube formation and proliferation by human um...

journal_title：Experimental eye research

authors： Chikaraishi Y,Matsunaga N,Shimazawa M,Hara H

更新日期：2008-01-01 00:00:00

abstract：:Transport of circulating reduced glutathione (GSH) was studied at the basolateral side of the lens epithelium by using an in situ vascular eye perfusion technique in guinea-pigs with rapid sampling to ensure detecting initial uptakes. The unidirectional transport rates of [35S]-GSH (4 nM) from plasma and aqueous into ...

journal_title：Experimental eye research

authors： Mackic JB,Jinagouda S,McComb JG,Weiss MH,Kannan R,Kaplowitz N,Zlokovic BV

更新日期：1996-01-01 00:00:00

abstract：:The aim of this study was to examine the murine subbasal nerve fibre plexus (SNP) regeneration altered by surgical dissection. Investigations in the mouse model addressed the regeneration capabilities of the SNP, and the influence of local ciliary neurotrophic factor (CNTF) application on the regeneration process. In ...

journal_title：Experimental eye research

authors： Reichard M,Hovakimyan M,Guthoff RF,Stachs O

更新日期：2014-03-01 00:00:00

abstract：:The anterior avian cornea possesses several distinct cellular and extracellular regions including the epithelial basal lamina, Bowman's layer and the interfacial matrix that separates Bowman's layer from the stroma. These unique regions differ biochemically, physically and morphologically but all contain type XII coll...

journal_title：Experimental eye research

authors： Marchant JK,Zhang G,Birk DE

更新日期：2002-12-01 00:00:00

abstract：:The purpose of this study was to evaluate specific keratocyte phenotypes (keratocyte, fibroblast, myofibroblast) for cell contractility and ability to contract extracellular matrix. Rabbit keratocyte phenotype was modulated by exposure to optimal proliferative doses of IGF-I, IL-1alpha, FGF2, PDGF-AB, and TGFbeta(1). ...

journal_title：Experimental eye research

authors： Jester JV,Ho-Chang J

更新日期：2003-11-01 00:00:00

abstract：:Reactive astrocytes in glaucomatous optic nerve changes are characterized by an increased expression of alphaB-crystallin and transforming growth factor-beta (TGF-beta). In the pathogenesis of glaucomatous optic nerve damage, ischemia/reperfusion injury may play an important role. The goal of the present study was to ...

journal_title：Experimental eye research

authors： Yu AL,Fuchshofer R,Birke M,Priglinger SG,Eibl KH,Kampik A,Bloemendal H,Welge-Lussen U

更新日期：2007-04-01 00:00:00

abstract：:Choroidal neovascularization (CNV) is one of the most frequent causes of severe and progressive vision loss, while its pathogenesis is still poorly understood. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, plays a crucial role in linking signals initiated by both the extracellular matrix (ECM) and solub...

journal_title：Experimental eye research

authors： Zhu J,Wang YS,Zhang J,Zhao W,Yang XM,Li X,Jiang TS,Yao LB

更新日期：2009-05-01 00:00:00

abstract：:Superoxide radicals or products generated by these radicals in a xanthine/xanthine oxidase system lyse cultured rat and human corneal epithelial cells as measured in a chromium-51 release assay. Partial protection from this lysis is afforded by superoxide dismutase and complete protection is obtained with catalase. Hy...

journal_title：Experimental eye research

authors： Hayden BJ,Zhu L,Sens D,Tapert MJ,Crouch RK

更新日期：1990-01-01 00:00:00