Abstract：
:This study investigated the changes in pH during retinal artery occlusion by means of extracellular H+ concentration ([H+]o) measurements in the retina under both air and 100% O2 ventilation. Occlusion was produced in intact anesthetised cats by pressing with a probe onto a retinal artery. [H+]o profiles were recorded across the retina with pH sensitive microelectrodes. The average inner retinal [H+]o increased during occlusion, resulting in an acidification of as much as 0.10 pH units, even under 100% O2 ventilation. The inner retinal H+ profile magnitude decreased during occlusion due to impaired clearance. The average outer retinal H+ profile magnitude also increased even though outer retinal H+ production did not increase during occlusion. This might be due to H+ diffusion from the inner retina to the outer retina, which is opposite to the flux in the normal retina. After reperfusion, [H+]o returned to its preocclusion value. In conclusion, arterial occlusion leads to acidification of the retina. Enhanced oxygenation during occlusion did not decrease this acidification. This may explain why increasing PO2 in the retina by enhanced O2 breathing improves retinal function during and after occlusion, but does not totally reverse the effect of occlusion.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Birol G,Budzynski E,Wangsa-Wirawan ND,Linsenmeier RAdoi
10.1016/j.exer.2004.11.002keywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
527-33issue
4eissn
0014-4835issn
1096-0007pii
S0014-4835(04)00331-8journal_volume
80pub_type
杂志文章abstract：:The wound-healing response is critical to the outcome of refractive surgery and studying wound healing contributes to an understanding of the pathophysiology of other corneal injuries. Animal models allow research to be conducted with sufficient samples and under controlled parameters. We studied the hen to determine ...
journal_title：Experimental eye research
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journal_title：Experimental eye research
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doi：10.1006/exer.1996.0212
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journal_title：Experimental eye research
pub_type： 杂志文章
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
pub_type： 杂志文章,评审
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2009.01.011
更新日期：2009-06-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.1994.1130
更新日期：1994-10-01 00:00:00
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journal_title：Experimental eye research
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doi：10.1006/exer.2002.2013
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journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：1988-09-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.1994.1037
更新日期：1994-04-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2003.10.015
更新日期：2004-02-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2018.12.003
更新日期：2019-03-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章,评审
doi：10.1016/0014-4835(90)90121-a
更新日期：1990-06-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2012.10.013
更新日期：2013-01-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2007.01.021
更新日期：2007-06-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章,评审
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2008.03.010
更新日期：2008-06-01 00:00:00
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更新日期：2017-02-01 00:00:00
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journal_title：Experimental eye research
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更新日期：2013-09-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2008.08.021
更新日期：2008-12-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.1997.0336
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abstract：:The aim of this study was to develop consistently focal elevated choroidal masses of human choroidal melanoma in immunosuppressed rabbits and to correlate the visualization of prognostically significant microcirculation patterns from confocal indocyanine green angiography with histologic microcirculation patterns. A h...
journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.1998.0650
更新日期：1999-06-01 00:00:00
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journal_title：Experimental eye research
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doi：10.1016/0014-4835(92)90164-n
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