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Urinary transglutaminase 2 as a potent biomarker to predict interstitial fibrosis and tubular atrophy of kidney allograft during early posttransplant period in deceased donor kidney transplantation.

Abstract：

Purpose:Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested whether quantification of urinary TG2 may represent a noninvasive method to estimate the severity of kidney allograft fibrosis. Methods:We prospectively collected urine specimens from 18 deceased donor kidney transplant recipients at 1-day, 7-day, 1-month, 3-month, and 6-month posttransplant. In addition, kidney allograft tissue specimens at 0-day and 6-month posttransplant were sampled to analyze the correlation of urinary TG2 and kidney allograft fibrosis. Results:Thirteen recipients had increased interstitial fibrosis and tubular atrophy (IFTA) scores at the 6-month protocol biopsy (IFTA group). The mean level of urinary TG2 in the IFTA group was higher compared to that of 5 other recipients without IFTA (no IFTA group). Conversely, the mean level of urinary syndecan-4 in the IFTA group was lower than levels in patients without IFTA. In the IFTA group, double immunofluorescent staining revealed that TG2 intensity was significantly upregulated and colocalizations of TG2/heparin sulfate proteoglycan and nuclear syndecan-4 were prominent, usually around tubular structures. Conclusion:Urinary TG2 in early posttransplant periods is a potent biomarker for kidney allograft inflammation or fibrosis.

journal_name

Ann Surg Treat Res

journal_title

Annals of surgical treatment and research

authors

Kim JY,Wee YM,Choi MY,Jung HR,Choi JY,Kwon HW,Jung JH,Cho YM,Go H,Han M,Kim YH,Han DJ,Shin S

doi

10.4174/astr.2019.97.1.27

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

27-35

issue

1

eissn

2288-6575

issn

2288-6796

journal_volume

97

pub_type

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