Abstract：
PURPOSE:The aim of this study is to know whether silibinin has an anticancer effect on triple negative breast cancer xenograft model using MDA-MB-468 cells. METHODS:To establish the xenograft model, we injected the MDA-MB-468 cells into female Balb/c-nude mice. After establishing a xenograft model, oral silibinin was administered to the tested mice in the way of 200 mg/kg for 45 days. The difference of mean tumor volume between silibinin fed mice and control mice was analyzed. The epidermal growth factor receptor (EGFR) phosphorylation in MDA-MB-468 cells was analyzed by Western blotting. The expression of VEGF, COX-2, and MMP-9 genes in tumor tissue was analyzed by real-time polymerase chain reaction (PCR). RESULTS:In the xenograft model using MDA-MB-468 cells, we found that oral administration of silibinin significantly suppressed the tumor volume (silibinin treated mice vs. control mice; 230.3 ± 61.6 mm(3) vs. 435.7 ± 93.5 mm(3), P < 0.001). The phosphorylation of EGFR in MDA-MB-468 cells was inhibited by treatment with 50 µg/mL of silibinin. In real time-PCR analysis of tumor tissue obtained from sacrificed mice, the gene expression of MMP-9, VEGF, and COX-2 was 51.8%-80% smaller in silibinin group than that of control group and we can also verify the similar result using Western blotting analysis. CONCLUSION:We verified that silibinin had anticancer effect on xenograft model of MDA-MB-468 cells in the way of preventing the phosphorylation of EGFR and eventually suppressed the production of COX-2, VEGF, and MMP-9 expression. Finally, the tumor volume of xenograft models was decreased after administration of Silibinin.
journal_name
Ann Surg Treat Resjournal_title
Annals of surgical treatment and researchauthors
Kil WH,Kim SM,Lee JE,Park KS,Nam SJdoi
10.4174/astr.2014.87.4.167subject
Has Abstractpub_date
2014-10-01 00:00:00pages
167-73issue
4eissn
2288-6575issn
2288-6796journal_volume
87pub_type
杂志文章abstract：:Vitelline veins are a pair of embryonic structures. The veins develop the portal vein system. Serious problems occur if the vitelline vein does not regress and becomes an aneurysm. Thrombus formation in the vitelline vein aneurysm could lead to portal vein thrombosis and portal hypertension unless promptly and correct...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2015.89.6.334
更新日期：2015-12-01 00:00:00
abstract：:The majority of malignant melanomas in the small intestine are metastases from primary cutaneous lesions, it can also develop as a primary mucosal tumor in the gastrointestinal tract. In this report, we present rare cases of primary small bowel melanoma and review the current literature. A 78-year-old male presented w...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2018.94.5.274
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:The aim of our study is to evaluate the effects of administration of perioperative supplemental oxygen on anastomoses. METHODS:Forty male Wistar albino rats were used in the study and randomized into 4 groups. Ischemia-reperfusion models were built in groups 3 and 4. Jejunojejunostomy was performed in all rats...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.89.1.17
更新日期：2015-07-01 00:00:00
abstract：Purpose:Laparoscopic antireflux surgery is not widely used in Korea, but published data suggest that its results are comparable to those of Western countries. The purpose of this study was to compare the clinical characteristics, medical utilization, and medical costs of antireflux surgery and proton pump inhibitor (PP...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2020.98.5.254
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:This study aimed to compare the learning curves and early postoperative outcomes for conventional laparoscopic (CL) and single incision laparoscopic (SIL) right hemicolectomy (RHC). METHODS:This retrospective study included the initial 35 cases in each group. Learning curves were evaluated by the moving averag...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.88.5.269
更新日期：2015-05-01 00:00:00
abstract：:Gastrointestinal (GI) tract metastasis of primary breast cancer is very rare. We present a patient with small bowel obstruction from distant metastasis of primary breast cancer. Each characteristic features of concern of GI tract distant metastasis from many pervious studies has been reported differently. We should re...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2018.94.2.102
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:To investigate the feasibility and safety of solo surgery with single-port laparoscopic appendectomy, which is termed herein solo-SPLA (solo-single-port laparoscopic appendectomy). METHODS:This study prospectively collected and retrospectively analyzed data from patients who had undergone either non-solo-SPLA ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.90.3.164
更新日期：2016-03-01 00:00:00
abstract：Purpose:Infection remains the main cause of morbidity and mortality in liver transplantation (LT) recipients; however infection is notoriously difficult to diagnose because its usual signs and symptoms of infection may be masked or absent. This study comprises an analysis of bacterial infections in the early period aft...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.94.3.154
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:To analyze the benefit and feasibility of this procedure compared with those of open method. METHODS:Abdominal procedure includes laparoscopic gastric mobilization, celiac axis lymph node dissection, formation of the gastric tube, and pyloromyotomy. The actual procedure performed during open surgery is the sam...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.89.3.117
更新日期：2015-09-01 00:00:00
abstract：PURPOSE:We evaluate the operative outcome and oncologic outcome of laparoscopic liver resection for hepatocellular carcinoma (HCC), and compare with open liver resection. METHODS:From January 2004 to December 2012, clinical data of 70 patients who underwent laparoscopic liver resection for HCC (laparoscopic liver rese...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.86.2.61
更新日期：2014-02-01 00:00:00
abstract：:Single-incision laparoscopic surgery has gained increasing attention due to its potential to improve the benefits of laparoscopic surgery. However, inconvenience remains for inexperienced surgeons during surgery when instruments conflict with each other, and a glove port is used hesitantly for such diagnosis related g...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2015.89.5.284
更新日期：2015-11-01 00:00:00
abstract：PURPOSE:Trauma team activation (TTA) has been shown to have fundamental impact on trauma patients' outcomes. The purpose of this study was to evaluate the short-term outcomes of use of a new TTA protocol in the management of major trauma patients who underwent exploratory laparotomy. METHODS:The medical records of tra...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.87.6.319
更新日期：2014-12-01 00:00:00
abstract：Purpose:The anatomical variations of the thyroid gland including separate thyroidal remnant at the thyrothymic area are of significance during thyroid surgery for "total" thyroidectomy, and for recurrent goitre. In the present study, we aimed to detect the separate rests of thyroidal tissue in the thyrothymic region. ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2020.98.3.111
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:Bariatric surgery has become more prevalent owing to the worldwide obesity epidemic. With the growing number of bariatric procedures performed annually, the requirement for revisional and secondary operations is increasing accordingly. This study aimed to evaluate the initial experience of revisional bariatric ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.86.6.295
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:The aim of this study was to find risk factors for early recurrence (ER) and early death (ED) after liver resection for colorectal cancer liver metastasis (CRCLM). METHODS:Between May 1990 and December 2011, 279 patients underwent liver resection for CRCLM at Korea University Medical Center. They were assigned...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.90.5.257
更新日期：2016-05-01 00:00:00
abstract：PURPOSE:Takayasu arteritis is an indication for bypass surgery when this condition results in severe cerebrovascular ischemia due to occlusion of the carotid arteries. We reviewed the patients with Takayasu arteritis who received aorto-carotid bypass due to cerebrovascular ischemia. METHODS:A retrospective review was ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2017.93.3.143
更新日期：2017-09-01 00:00:00
abstract：:Laparoscopic live donor nephrectomy (DN) has been established as a useful alternative to the traditional open methods of procuring kidneys. To maximize the advantages of the laparoendoscopic single-site (LESS) method, we applied natural orifice specimen extraction to LESS-DN. A 46-year-old woman with no previous abdom...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2016.90.2.111
更新日期：2016-02-01 00:00:00
abstract：:Endovascular aneurysm repair is a minimally invasive, durable and effective alternative to open surgery for treatment of abdominal aortic aneurysms (AAA). However, in patients who do not have an adequate sealing zone, open surgical repair is required, which may increase mortality and morbidity. An alternative treatmen...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2014.86.5.274
更新日期：2014-05-01 00:00:00
abstract：Purpose:A soft texture of the pancreas is one of the most important predisposing factors for a pancreatic fistula. Thus, in a porcine model, we investigated a method to harden the pancreas locally by directly injecting an artificial material. Methods:During the laparotomy, 51 samples from 17 pigs, including 13 surviva...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.95.4.175
更新日期：2018-10-01 00:00:00
abstract：:Hepatic tuberculosis (TB) is usually associated with pulmonary or miliary TB, but primary hepatic TB is very uncommon even in countries with high prevalence of TB. The clinical manifestation of primary hepatic TB is atypical and imaging modalities are unhelpful for differential diagnosis of the liver mass. Image-guide...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2015.89.2.98
更新日期：2015-08-01 00:00:00
abstract：PURPOSE:To determine the prevalence of thrombophilia in Korean patients with an arterial thromboembolism (ATE) or a venous thromboembolism (VTE), and to evaluate the characteristic of VTE in patients with thrombophilia. METHODS:Hospital records of 294 patients (228 with VTE, 66 with ATE) including two foreign ones (me...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.90.6.340
更新日期：2016-06-01 00:00:00
abstract：:We present the case of young female patient presenting with acute onset abdominal pain. Abdominopelvic CT revealed herniation through the foramen of Winslow. The patient was transferred to our hospital and underwent laparoscopic exploration. Though spontaneous reduction was detected, segmental resection of the impacte...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2017.92.2.113
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:Little is known about the clinicopathological features of early mucinous gastric carcinoma (MGC). The purpose of this study was to compare the clinicopathological features and prognosis between patients with early MGC and those with early nonmucinous gastric carcinoma (NMGC). METHODS:We reviewed the records of...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.87.1.5
更新日期：2014-07-01 00:00:00
abstract：Purpose:Recently a controversy has arisen about so-called "ghost surgery" practices, and people have voiced their opinions for legal sanction against such practices, which clearly undermine the foundation of medical ethics. However, there has been a lack of legal basis for punishing those actions. The present study aim...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.94.4.167
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:The aim of the present study was to identify the radiation hazards to vascular surgeons and scrub nurses working in mobile fluoroscopy equipped hybrid vascular operation rooms; additionally, to estimate cumulative cancer risk due to certain exposure dosages. METHODS:The study was conducted prospectively in 71 ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2017.92.3.156
更新日期：2017-03-01 00:00:00
abstract：Purpose:The incidence of colonic diverticular disease is increasing, and several grading systems based on CT findings have been developed. The objective of this study was to define the impact of various CT findings of colonic diverticulitis and to demonstrate which factors affect the need for operative treatment. Meth...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.94.6.322
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:This study aimed to determine which factors affect the prognosis of hepatectomy for hepatocellular carcinoma (HCC) larger than 5 cm, including the prognostic difference between tumor sizes from 5-10 cm and larger than 10 cm. METHODS:The medical records of 114 patients who underwent hepatectomy for single HCC l...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.91.3.104
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:We aimed to develop an effective system for surgical site infection (SSI) surveillance and examine the current domestic state of SSIs for common abdominal surgeries in Korea. METHODS:The Korean Surgical Site Infection Surveillance (KOSSIS) program was developed as an SSI surveillance system. A prospective mult...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.88.3.119
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:The purpose of this study was to investigate the effectiveness and safety of monitored anesthesia care (MAC) using dexmedetomidine for its sedative and analgesic effect during varicose vein surgery. METHODS:Forty-two patients, who underwent varicose vein surgery, were divided into the MAC group (n = 20) or the...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.87.5.245
更新日期：2014-11-01 00:00:00
abstract：Purpose:Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested whether quantification of urinary TG2 may represent a noninvasive method to estimate the severity of kidney allograft fibrosis. Methods:We prospectively collected urine specimens from ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2019.97.1.27
更新日期：2019-07-01 00:00:00
