Prognostic factors after hepatic resection for the single hepatocellular carcinoma larger than 5 cm.

Abstract:

PURPOSE:This study aimed to determine which factors affect the prognosis of hepatectomy for hepatocellular carcinoma (HCC) larger than 5 cm, including the prognostic difference between tumor sizes from 5-10 cm and larger than 10 cm. METHODS:The medical records of 114 patients who underwent hepatectomy for single HCC larger than 5 cm were reviewed and analyzed retrospectively. RESULTS:In the analysis of the entire cohort of 114 patients, the 5-year overall and diseases-free survival rates were 50% and 29%, respectively. In a comparison of survival rates between groups, tumor sizes of 5 to 10 cm and larger than 10 cm, the overall and disease-free survival rates were not significantly different, respectively (54% vs. 41%, P = 0.433 and 33% vs. 23%, P = 0.083). On multivariate analysis, positive hepatitis B, high prothrombin induced by vitamin K absence or antagonist-II levels over 200 mIU/mL, and vascular invasion (micro- and macrovascular invasion) were independent prognostic factors for recurrence after hepatic resection. However, tumor size larger than 10 cm was not significant for recurrence after resection. CONCLUSION:This study shows that surgical resection of solitary HCC larger than 5 cm showed favorable overall survival. And there is no survival difference with tumors between 5-10 cm and larger than 10 cm.

journal_name

Ann Surg Treat Res

authors

Noh JH,Kim TS,Ahn KS,Kim YH,Kang KJ

doi

10.4174/astr.2016.91.3.104

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

104-11

issue

3

eissn

2288-6575

issn

2288-6796

journal_volume

91

pub_type

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