Abstract：
Purpose:Many patients with cytology proven node-positive breast cancer receive a neoadjuvant chemotherapy (NAC) treatment. We developed a nomogram to predict the breast and axillary pathologic complete responses (pCR) in patients with a cytologically proven axillary node positive breast cancer with NAC. Methods:We selected 995 patients who were diagnosed with an invasive breast cancer and axillary lymph nodes metastasis, and who were treated with NAC followed by a curative surgery at the Samsung Medical Center between January 2007 and December 2014. The baseline patient and tumor characteristics, chemotherapy regimen, and tumor and nodal responses were thoroughly analyzed and reviewed. A nomogram was developed using a binary logistic regression model with a cross validation. Results:Axillary pCR was achieved in 47.3% and breast pCR was achieved in 24.3% of the patients after NAC. In this case, the both pCR was associated with an initial clinical tumor stage, negative progesterone receptor status, positive human epidermal growth factor receptor 2 status, and clinical radiologic nodal responses. A nomogram was developed based on the clinical and statistically significant predictors. It had good discrimination performance (area under the curve [AUC], 0.868; 95% confidence interval, 0.84-0.89) and calibration fit as noted in that case. The cross validation had an average AUC 0.853 (0.837-0.869). Conclusion:Our nomogram might help to predict breast and axillary pCRs after NAC in patients with an initially node-positive breast cancer. Minimal surgery might be acceptable in patients for whom the nomogram indicates a high probability of achieving pCRs.
journal_name
Ann Surg Treat Resjournal_title
Annals of surgical treatment and researchauthors
Choi HJ,Ryu JM,Kim I,Nam SJ,Kim SW,Yu J,Lee JE,Lee SKdoi
10.4174/astr.2019.96.4.169subject
Has Abstractpub_date
2019-04-01 00:00:00pages
169-176issue
4eissn
2288-6575issn
2288-6796journal_volume
96pub_type
杂志文章abstract：Purpose:Recent studies investigating new strategies to modulate the immune system have utilized animal models of liver transplantation (LT). However, the anhepatic phase (AHP) remains a crucial problem in LT. The aim of the present study is to introduce a technique for successful orthotopic LT in cynomolgus monkeys usi...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.94.1.8
更新日期：2018-01-01 00:00:00
abstract：Purpose:Laparoscopic antireflux surgery is not widely used in Korea, but published data suggest that its results are comparable to those of Western countries. The purpose of this study was to compare the clinical characteristics, medical utilization, and medical costs of antireflux surgery and proton pump inhibitor (PP...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2020.98.5.254
更新日期：2020-05-01 00:00:00
abstract：Purpose:Preoperative chemoradiation therapy (CRT) has become the standard treatment for patients with locally advanced rectal cancer, 15%-30% of patients still progress while being treated with CRT. The aim of this study was to identify as important biomarker of poor response and evaluate the mechanism associated with ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2019.97.2.83
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:Management of appendicitis in children has always been an issue in pediatric surgery. Both diagnostic methods and treatment vary significantly among medical centers, and little consensus exists in many aspects of the care for patients with appendicitis. Here, we assessed the value of drain insertion after appen...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.88.6.341
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:Recently, the number of elderly patients has increased due to a longer life expectancy. Among these elderly patients, more octogenarians will be diagnosed with major hepatobiliary pancreatic (HBP) diseases. Therefore, we need to evaluate the safety and risk factors of major HBP surgery in patients older than 80...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.91.6.288
更新日期：2016-12-01 00:00:00
abstract：Purpose:Infection remains the main cause of morbidity and mortality in liver transplantation (LT) recipients; however infection is notoriously difficult to diagnose because its usual signs and symptoms of infection may be masked or absent. This study comprises an analysis of bacterial infections in the early period aft...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.94.3.154
更新日期：2018-03-01 00:00:00
abstract：Purpose:Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested whether quantification of urinary TG2 may represent a noninvasive method to estimate the severity of kidney allograft fibrosis. Methods:We prospectively collected urine specimens from ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2019.97.1.27
更新日期：2019-07-01 00:00:00
abstract：PURPOSE:Bariatric surgery has become more prevalent owing to the worldwide obesity epidemic. With the growing number of bariatric procedures performed annually, the requirement for revisional and secondary operations is increasing accordingly. This study aimed to evaluate the initial experience of revisional bariatric ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.86.6.295
更新日期：2014-06-01 00:00:00
abstract：Purpose:There has been an increasing trend in the use of contralateral prophylactic mastectomy (CPM) among women diagnosed with unilateral breast cancer or mutations in BRCA1 or BRCA2 to reduce the occurrence of contralateral breast cancer. This study aimed to examine trends in the CPM rate according to clinicopatholog...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2019.97.3.113
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:The aim of this study was to compare postoperative pain between single-incision, gasless, endoscopic transaxillary thyroidectomy (SET), and conventional open thyroidectomy. METHODS:From March to December 2015, patients with thyroid disease underwent total thyroidectomy or lobectomy. Patient's clinical and path...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2017.92.1.9
更新日期：2017-01-01 00:00:00
abstract：:Pediatric arterial aneurysm is rare disease. Among them, idiopathic-congenital arterial aneurysm is extremely rare. This is a case report of right common iliac artery idiopathic aneurysm with absence of right external iliac artery. A 4-year-old girl who had been complaining of intermittent abdominal pain since 2 years...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2016.91.5.265
更新日期：2016-11-01 00:00:00
abstract：Purpose:Increased robotic surgery is attended by increased reports of complications, largely due to limited operative view and lack of tactile sense. These kinds of obstacles, which seldom occur in open surgery, are challenging for beginner surgeons. To enhance robotic surgery safety, we created an augmented reality (A...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.95.6.297
更新日期：2018-12-01 00:00:00
abstract：Purpose:Thyroid reoperations are surgically challenging because of significant anatomical variance. Visual and functional identification of the external branch of the superior laryngeal nerve (EBSLN) were studied in 2 groups of patients who underwent primary and redo thyroid surgery. Methods:This study was conducted o...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2019.96.6.269
更新日期：2019-06-01 00:00:00
abstract：PURPOSE:Takayasu arteritis is an indication for bypass surgery when this condition results in severe cerebrovascular ischemia due to occlusion of the carotid arteries. We reviewed the patients with Takayasu arteritis who received aorto-carotid bypass due to cerebrovascular ischemia. METHODS:A retrospective review was ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2017.93.3.143
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:To identify the correlation of the model for end-stage liver disease (MELD) scores with the assessment of the risk of hepatic function after hemihepatectomy in patients with hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV). METHODS:A case-control study was performed based on data for 141 conse...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.86.3.122
更新日期：2014-03-01 00:00:00
abstract：PURPOSE:Severe local and systemic tissue damage called ischemia/reperfusion (IR) injury occurs during the period of reperfusion. Free oxygen radicals and proinflammatory cytokines are responsible for reperfusion injury. IL-18 binding protein (IL-18BP) is a natural inhibitor of IL-18. The balance between IL-18 and IL-18...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.88.2.92
更新日期：2015-02-01 00:00:00
abstract：Purpose:Meckel diverticulum (MD), caused by an obliteration defect of the omphalomesenteric duct, is one of the most common congenital anomalies of small intestines. The objective of this study was to review surgical outcomes of MD and evaluate the feasibility of minimally invasive surgery (MIS) in MD. Methods:We perf...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2020.99.4.213
更新日期：2020-10-01 00:00:00
abstract：:We present the case of young female patient presenting with acute onset abdominal pain. Abdominopelvic CT revealed herniation through the foramen of Winslow. The patient was transferred to our hospital and underwent laparoscopic exploration. Though spontaneous reduction was detected, segmental resection of the impacte...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2017.92.2.113
更新日期：2017-02-01 00:00:00
abstract：Purpose:Skin grafts have been widely used in managing extensive chest wall defects after mastectomy for advanced breast cancer. However, their durability and tolerability to radiotherapy is still controversial. A thoracoabdominal (TA) flap with a few technical refinements can safely transfer a larger flap while minimiz...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2019.97.4.168
更新日期：2019-10-01 00:00:00
abstract：Purpose:Spontaneous gastrointestinal perforations (SGIPs; not associated with injury or disease) occur rarely in pediatric patients. This study aimed to define age-specific features associated with SGIPs in pediatric patients. Methods:Retrospectively reviewed the clinical data of children (before adolescence) who rece...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.95.3.141
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:Downstaging after chemoradiotherapy (CRT) for rectal cancer usually occurs. The present study aimed to evaluate pathologic y-stage (yp-stage) and its influence on local recurrence and systemic recurrence in rectal cancer patients treated with CRT followed by surgical resection. METHODS:We retrospectively analy...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.88.1.15
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:Treatment of patients with para-aortic lymph node metastasis from colorectal cancer is controversial. The goal of this study was to investigate the technical feasibility of laparoscopic intrarenal para-aortic lymph node dissection in patients with colorectal cancer and clinically suspected para-aortic lymph nod...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.90.1.29
更新日期：2016-01-01 00:00:00
abstract：PURPOSE:We evaluate the operative outcome and oncologic outcome of laparoscopic liver resection for hepatocellular carcinoma (HCC), and compare with open liver resection. METHODS:From January 2004 to December 2012, clinical data of 70 patients who underwent laparoscopic liver resection for HCC (laparoscopic liver rese...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.86.2.61
更新日期：2014-02-01 00:00:00
abstract：Purpose:Tenofovir disoproxil fumarate is accepted as an effective and tolerable drug for treatment of HBV, similar to entecavir. However, there are some concerns about the nephrotoxicity of tenofovir. The aim of this study is to compare the renal-function change of liver recipients who received tenofovir or entecavir f...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2020.99.3.180
更新日期：2020-09-01 00:00:00
abstract：:Gastrointestinal (GI) tract metastasis of primary breast cancer is very rare. We present a patient with small bowel obstruction from distant metastasis of primary breast cancer. Each characteristic features of concern of GI tract distant metastasis from many pervious studies has been reported differently. We should re...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2018.94.2.102
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:To investigate the feasibility and safety of solo surgery with single-port laparoscopic appendectomy, which is termed herein solo-SPLA (solo-single-port laparoscopic appendectomy). METHODS:This study prospectively collected and retrospectively analyzed data from patients who had undergone either non-solo-SPLA ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.90.3.164
更新日期：2016-03-01 00:00:00
abstract：:[This corrects the article on p. 106 in vol. 88, PMID: 25692122.]. ...
journal_title：Annals of surgical treatment and research
pub_type： 已发布勘误
doi：10.4174/astr.2015.88.3.178
更新日期：2015-03-01 00:00:00
abstract：PURPOSE:The postoperative treatment after appendectomy is usually decided on the basis of the surgeons' intraoperative findings. Comparatively, the pathologic diagnosis of appendicitis is confirmed several days after the surgery; therefore, it usually does not affect the postoperative treatment strategy. The aim of thi...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2017.93.1.43
更新日期：2017-07-01 00:00:00
abstract：PURPOSE:The aim of our study is to evaluate the effects of administration of perioperative supplemental oxygen on anastomoses. METHODS:Forty male Wistar albino rats were used in the study and randomized into 4 groups. Ischemia-reperfusion models were built in groups 3 and 4. Jejunojejunostomy was performed in all rats...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.89.1.17
更新日期：2015-07-01 00:00:00
abstract：Purpose:The aim of this study was to compare the large multi-institutional data of surgical outcomes of bilateral axillo-breast approach (BABA) robotic (RT) and endoscopic thyroidectomy (ET) and to evaluate the merits of robotic thyroidectomy. Methods:From 2004 to 2015, 1,029 patients underwent BABA ET, and from 2008 ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2020.98.6.307
更新日期：2020-06-01 00:00:00
