Abstract：
Purpose:Preoperative chemoradiation therapy (CRT) has become the standard treatment for patients with locally advanced rectal cancer, 15%-30% of patients still progress while being treated with CRT. The aim of this study was to identify as important biomarker of poor response and evaluate the mechanism associated with CRT resistance. Methods:This study included 60 human colon tumour pre-irradiation specimens. Expressions of epidermal growth factor receptor (EGFR), p53, Krüppel-like factor 5 (KLF5), C-ern, Ki67 were assessed and correlated with tumor regression grades and complete remission. We added in vitro study with biomarker which has been identified as important biomarker of poor response to evaluate the mechanism associated with CRT resistance. Results:Pathologic complete remission (pCR) was achieved by 9 patients (18%). EGFR and KLF5 were significantly associated with pCR (P = 0.048, P = 0.023, respectfully). And multivariate analysis showed high KLF5 intensity was worse factor for pCR (P = 0.012). In vitro study, radiation or chemotherapy therapy stabilized KLF5 protein levels in a time- and dose-depended manner in HCT116 and Caco-2 cells. KLF5 overexpression in HCT116 stable cell line showed significantly better cell viability by increasing cyclinD1 and b-catenin compared to control cells in MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, suggesting that KLF5 mediates cell survival. Conclusion:KLF5 was significantly associated with the presence of KRAS mutations, and KLF5 was an independent poor response predictor of CRT in rectal cancer. Our study is pilot study and more research will be needed in the future.
journal_name
Ann Surg Treat Resjournal_title
Annals of surgical treatment and researchauthors
Kim JY,Park SG,Kim KS,Choi YH,Kim NKdoi
10.4174/astr.2019.97.2.83subject
Has Abstractpub_date
2019-08-01 00:00:00pages
83-92issue
2eissn
2288-6575issn
2288-6796journal_volume
97pub_type
杂志文章abstract：PURPOSE:Downstaging after chemoradiotherapy (CRT) for rectal cancer usually occurs. The present study aimed to evaluate pathologic y-stage (yp-stage) and its influence on local recurrence and systemic recurrence in rectal cancer patients treated with CRT followed by surgical resection. METHODS:We retrospectively analy...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.88.1.15
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:The aim of the present study was to identify the radiation hazards to vascular surgeons and scrub nurses working in mobile fluoroscopy equipped hybrid vascular operation rooms; additionally, to estimate cumulative cancer risk due to certain exposure dosages. METHODS:The study was conducted prospectively in 71 ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2017.92.3.156
更新日期：2017-03-01 00:00:00
abstract：PURPOSE:Takayasu arteritis is an indication for bypass surgery when this condition results in severe cerebrovascular ischemia due to occlusion of the carotid arteries. We reviewed the patients with Takayasu arteritis who received aorto-carotid bypass due to cerebrovascular ischemia. METHODS:A retrospective review was ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2017.93.3.143
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:Trauma team activation (TTA) has been shown to have fundamental impact on trauma patients' outcomes. The purpose of this study was to evaluate the short-term outcomes of use of a new TTA protocol in the management of major trauma patients who underwent exploratory laparotomy. METHODS:The medical records of tra...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.87.6.319
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:The aim of our study is to evaluate the effects of administration of perioperative supplemental oxygen on anastomoses. METHODS:Forty male Wistar albino rats were used in the study and randomized into 4 groups. Ischemia-reperfusion models were built in groups 3 and 4. Jejunojejunostomy was performed in all rats...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.89.1.17
更新日期：2015-07-01 00:00:00
abstract：PURPOSE:The purpose of this study was to investigate the effectiveness and safety of monitored anesthesia care (MAC) using dexmedetomidine for its sedative and analgesic effect during varicose vein surgery. METHODS:Forty-two patients, who underwent varicose vein surgery, were divided into the MAC group (n = 20) or the...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.87.5.245
更新日期：2014-11-01 00:00:00
abstract：PURPOSE:The authors evaluate the prevalence of malnutrition and its effect on the postoperative morbidity of patients after surgery for colorectal cancer. METHODS:Three hundred fifty-two patients were enrolled prospectively. Nutritional risk screening 2002 (NRS 2002) score was calculated through interview with patient...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.86.4.206
更新日期：2014-04-01 00:00:00
abstract：Purpose:Evaluating the risk of lymph node metastasis (LNM) is critical for determining subsequent treatments following endoscopic resection of T1 colorectal cancer (CRC). This study analyzed histopathologic risk factors for LNM in patients with T1 CRC. Methods:This study involved 745 patients with T1 CRC who underwent...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2017.93.5.266
更新日期：2017-11-01 00:00:00
abstract：PURPOSE:The aim of this study is to know whether silibinin has an anticancer effect on triple negative breast cancer xenograft model using MDA-MB-468 cells. METHODS:To establish the xenograft model, we injected the MDA-MB-468 cells into female Balb/c-nude mice. After establishing a xenograft model, oral silibinin was ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.87.4.167
更新日期：2014-10-01 00:00:00
abstract：:Anastomotic leakage following rectal resection is a serious and fearful complication, and may cause presacral abscess and/or peritonitis. To our knowledge, massive hematochezia secondary to presacral abscess caused by anastomotic leakage has not yet been reported in the literature. We observed this rare and life-threa...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2015.88.4.236
更新日期：2015-04-01 00:00:00
abstract：:Hepatic tuberculosis (TB) is usually associated with pulmonary or miliary TB, but primary hepatic TB is very uncommon even in countries with high prevalence of TB. The clinical manifestation of primary hepatic TB is atypical and imaging modalities are unhelpful for differential diagnosis of the liver mass. Image-guide...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2015.89.2.98
更新日期：2015-08-01 00:00:00
abstract：:The concept of complete mesocolic excision and central vascular ligation for colonic cancer has been recently introduced. The paper describes a technique of right-sided complete mesocolic excision and intracorporeal anastomosis by using a single-port robotic approach with an additional conventional robotic port. We pe...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.91.4.212
更新日期：2016-10-01 00:00:00
abstract：:Laparoscopic live donor nephrectomy (DN) has been established as a useful alternative to the traditional open methods of procuring kidneys. To maximize the advantages of the laparoendoscopic single-site (LESS) method, we applied natural orifice specimen extraction to LESS-DN. A 46-year-old woman with no previous abdom...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2016.90.2.111
更新日期：2016-02-01 00:00:00
abstract：:We report a case of synchronous multiple colon adenocarcinomas in a patient with neurofibromatosis type 1 (NF1). NF1 is an autosomal dominant inherited disorder and patients with NF1 have high risk for both benign and malignant tumors. However, adenocarcinomas involving the colon have rarely been reported in patients ...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2014.87.3.156
更新日期：2014-09-01 00:00:00
abstract：Purpose:Gastric emptying may influence the quality of life of patients who undergo distal gastrectomy. Little is known, however, about gastric emptying after distal gastrectomy. The aim of our study was to investigate gastric emptying patterns after distal gastrectomy. Methods:This gastric-emptying study investigated ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2017.93.6.310
更新日期：2017-12-01 00:00:00
abstract：Purpose:We conducted a multi-institutional analysis to establish the epidemiological characteristics of recurrent inguinal hernia following hernia repair in patients across 4 institutions in Korea. Methods:The retrospectively reviewed data included patient characteristics, hernia location, year of primary operation, t...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2020.98.1.51
更新日期：2020-01-01 00:00:00
abstract：Purpose:Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested whether quantification of urinary TG2 may represent a noninvasive method to estimate the severity of kidney allograft fibrosis. Methods:We prospectively collected urine specimens from ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2019.97.1.27
更新日期：2019-07-01 00:00:00
abstract：Purpose:To evaluate superiority of a night float (NF) system in comparison to a traditional night on-call (NO) system for surgical residents at a single institution in terms of efficacy, safety, and satisfaction. Methods:A NF system was implemented from March to September 2017 and big data analysis from electronic med...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2019.96.5.209
更新日期：2019-05-01 00:00:00
abstract：:The majority of malignant melanomas in the small intestine are metastases from primary cutaneous lesions, it can also develop as a primary mucosal tumor in the gastrointestinal tract. In this report, we present rare cases of primary small bowel melanoma and review the current literature. A 78-year-old male presented w...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2018.94.5.274
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:The aim of this study was to compare postoperative pain between single-incision, gasless, endoscopic transaxillary thyroidectomy (SET), and conventional open thyroidectomy. METHODS:From March to December 2015, patients with thyroid disease underwent total thyroidectomy or lobectomy. Patient's clinical and path...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2017.92.1.9
更新日期：2017-01-01 00:00:00
abstract：Purpose:The aim of this study was to compare the large multi-institutional data of surgical outcomes of bilateral axillo-breast approach (BABA) robotic (RT) and endoscopic thyroidectomy (ET) and to evaluate the merits of robotic thyroidectomy. Methods:From 2004 to 2015, 1,029 patients underwent BABA ET, and from 2008 ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2020.98.6.307
更新日期：2020-06-01 00:00:00
abstract：:Vitelline veins are a pair of embryonic structures. The veins develop the portal vein system. Serious problems occur if the vitelline vein does not regress and becomes an aneurysm. Thrombus formation in the vitelline vein aneurysm could lead to portal vein thrombosis and portal hypertension unless promptly and correct...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2015.89.6.334
更新日期：2015-12-01 00:00:00
abstract：Purpose:Laparoscopic antireflux surgery is not widely used in Korea, but published data suggest that its results are comparable to those of Western countries. The purpose of this study was to compare the clinical characteristics, medical utilization, and medical costs of antireflux surgery and proton pump inhibitor (PP...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2020.98.5.254
更新日期：2020-05-01 00:00:00
abstract：PURPOSE:Little is known about the clinicopathological features of early mucinous gastric carcinoma (MGC). The purpose of this study was to compare the clinicopathological features and prognosis between patients with early MGC and those with early nonmucinous gastric carcinoma (NMGC). METHODS:We reviewed the records of...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.87.1.5
更新日期：2014-07-01 00:00:00
abstract：Purpose:Spontaneous gastrointestinal perforations (SGIPs; not associated with injury or disease) occur rarely in pediatric patients. This study aimed to define age-specific features associated with SGIPs in pediatric patients. Methods:Retrospectively reviewed the clinical data of children (before adolescence) who rece...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.95.3.141
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:The 2-port laparoscopic appendectomy technique (TLA) is between the conventional 3-port and single-port laparoscopic appendectomy surgeries. We compared postoperative pain and cosmetic results after TLA with conventional laparoscopic appendectomy (CLA) by a 3-port device. METHODS:Patients undergoing TLA were m...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.91.2.59
更新日期：2016-08-01 00:00:00
abstract：Purpose:A soft texture of the pancreas is one of the most important predisposing factors for a pancreatic fistula. Thus, in a porcine model, we investigated a method to harden the pancreas locally by directly injecting an artificial material. Methods:During the laparotomy, 51 samples from 17 pigs, including 13 surviva...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.95.4.175
更新日期：2018-10-01 00:00:00
abstract：:[This corrects the article on p. 396 in vol. 92, PMID: 28580343.]. ...
journal_title：Annals of surgical treatment and research
pub_type： 已发布勘误
doi：10.4174/astr.2017.93.2.118
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:To identify the correlation of the model for end-stage liver disease (MELD) scores with the assessment of the risk of hepatic function after hemihepatectomy in patients with hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV). METHODS:A case-control study was performed based on data for 141 conse...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.86.3.122
更新日期：2014-03-01 00:00:00
abstract：Purpose:Repeating endoscopic retrograde cholangiopancreatography (ERCP) in patients with recurrent common bile duct (CBD) stones is problematic in many ways. Choledochoduodenostomy (CDS) and choledochojejunostomy (CJS) are 2 surgical treatment options for recurrent CBD stones, and each has different advantages and disa...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2020.99.6.329
更新日期：2020-12-01 00:00:00
