Abstract:
PURPOSE:Downstaging after chemoradiotherapy (CRT) for rectal cancer usually occurs. The present study aimed to evaluate pathologic y-stage (yp-stage) and its influence on local recurrence and systemic recurrence in rectal cancer patients treated with CRT followed by surgical resection. METHODS:We retrospectively analyzed 261 patients underwent preoperative CRT and radical resection for rectal cancer between August 2004 and December 2010. Patients received preoperative CRT consisting of 5-fluorouracil and leucovorin delivered with concurrent pelvic radiation of 45.0-50.4 Gy, followed by radical surgery at 6-8 weeks after CRT. RESULTS:Of the 261 patients, 24 (9.2%) had yp-stage 0, 83 (31.8%) had yp-stage I, 86 (32.9%) had yp-stage II, and 68 (26.1%) had yp-stage III. Patients with yp-stage III had a greater prevalence of preoperative CEA, poorly differentiated tumor, lymphovascular invasion (LVI) and perineural invasion (PNI) than patients with lower yp-stages. We found that yp-stage, preoperative CEA, LVI, PNI and tumor regression grade were significant prognostic factors for both local and systemic recurrence. In multivariate analysis, yp-stage, LVI and PNI were significant factors for local and systemic recurrence. During the median follow-up of 37.5 months, the five-year local recurrence-free survival rate was 100.0%, 95.0%, 89.3%, and 80.6% of yp-stage 0-III, respectively. The five-year systemic recurrence-free survival was 95.8%, 75.3%, 71.4%, and 48.8% of yp-stages 0-III, respectively. CONCLUSION:The yp-stage after preoperative CRT for rectal cancer is closely correlated with local and systemic recurrence-free survival. Therefore, yp-stage should be considered as a prognostic factor for rectal cancer patients having a course of preoperative CRT.
journal_name
Ann Surg Treat Resjournal_title
Annals of surgical treatment and researchauthors
Yoon WH,Kim HJ,Kim CH,Joo JK,Kim YJ,Kim HRdoi
10.4174/astr.2015.88.1.15subject
Has Abstractpub_date
2015-01-01 00:00:00pages
15-20issue
1eissn
2288-6575issn
2288-6796journal_volume
88pub_type
杂志文章abstract:PURPOSE:The aim of this study is to assess the long-term results of laparoscopic common bile duct exploration (LCBDE) and validate its effectiveness as a primary treatment modality for CBD stone. METHODS:A retrospective review of the medical records of 157 patients who underwent LCBDE from 1997 to 2011 was conducted. ...
journal_title:Annals of surgical treatment and research
pub_type: 杂志文章
doi:10.4174/astr.2014.86.1.1
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abstract::The concept of complete mesocolic excision and central vascular ligation for colonic cancer has been recently introduced. The paper describes a technique of right-sided complete mesocolic excision and intracorporeal anastomosis by using a single-port robotic approach with an additional conventional robotic port. We pe...
journal_title:Annals of surgical treatment and research
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abstract::Gastrointestinal (GI) tract metastasis of primary breast cancer is very rare. We present a patient with small bowel obstruction from distant metastasis of primary breast cancer. Each characteristic features of concern of GI tract distant metastasis from many pervious studies has been reported differently. We should re...
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abstract:Purpose:Laparoscopic antireflux surgery is not widely used in Korea, but published data suggest that its results are comparable to those of Western countries. The purpose of this study was to compare the clinical characteristics, medical utilization, and medical costs of antireflux surgery and proton pump inhibitor (PP...
journal_title:Annals of surgical treatment and research
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abstract:PURPOSE:The factors related to early-onset tumor recurrence in patients with spontaneously ruptured hepatocellular carcinoma (HCC) after hepatectomy remain unclear. The aims of the present study were to compare characteristics between early and late recurrence groups in spontaneously ruptured HCC patients who received ...
journal_title:Annals of surgical treatment and research
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abstract::Vitelline veins are a pair of embryonic structures. The veins develop the portal vein system. Serious problems occur if the vitelline vein does not regress and becomes an aneurysm. Thrombus formation in the vitelline vein aneurysm could lead to portal vein thrombosis and portal hypertension unless promptly and correct...
journal_title:Annals of surgical treatment and research
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abstract:Purpose:Recent studies have suggested microscopic positive resection margin should be revised according to the presence of tumor cells within 1mm of the margin surface in resected specimens of pancreatic cancer. However, the clinical meaning of this revised margin status for R1 resection margin was not fully clarified....
journal_title:Annals of surgical treatment and research
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abstract:Purpose:A soft texture of the pancreas is one of the most important predisposing factors for a pancreatic fistula. Thus, in a porcine model, we investigated a method to harden the pancreas locally by directly injecting an artificial material. Methods:During the laparotomy, 51 samples from 17 pigs, including 13 surviva...
journal_title:Annals of surgical treatment and research
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journal_title:Annals of surgical treatment and research
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doi:10.4174/astr.2019.97.2.83
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journal_title:Annals of surgical treatment and research
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abstract:Purpose:Clinically suspected T4 stage colon cancer from a preoperative exam is often diagnosed as T3 stage colon cancer pathologically after surgery, raising concerns about understaging. The aims of this study were to compare the survival of clinical T3 and T4 colon cancer patients who had received a pathologic T3 stag...
journal_title:Annals of surgical treatment and research
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更新日期:2020-07-01 00:00:00
abstract:Purpose:Infection remains the main cause of morbidity and mortality in liver transplantation (LT) recipients; however infection is notoriously difficult to diagnose because its usual signs and symptoms of infection may be masked or absent. This study comprises an analysis of bacterial infections in the early period aft...
journal_title:Annals of surgical treatment and research
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doi:10.4174/astr.2018.94.3.154
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:This study aimed to determine the mortality rate in patients with severe trauma and the risk factors for trauma mortality based on 3 years' data in a regional trauma center in Korea. METHODS:We reviewed the medical records of severe trauma patients admitted to Ajou University Hospital with an Injury Severity S...
journal_title:Annals of surgical treatment and research
pub_type: 杂志文章
doi:10.4174/astr.2015.89.4.215
更新日期:2015-10-01 00:00:00
abstract::The majority of malignant melanomas in the small intestine are metastases from primary cutaneous lesions, it can also develop as a primary mucosal tumor in the gastrointestinal tract. In this report, we present rare cases of primary small bowel melanoma and review the current literature. A 78-year-old male presented w...
journal_title:Annals of surgical treatment and research
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doi:10.4174/astr.2018.94.5.274
更新日期:2018-05-01 00:00:00
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journal_title:Annals of surgical treatment and research
pub_type:
doi:10.4174/astr.2014.87.3.156
更新日期:2014-09-01 00:00:00
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journal_title:Annals of surgical treatment and research
pub_type:
doi:10.4174/astr.2016.91.5.265
更新日期:2016-11-01 00:00:00
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journal_title:Annals of surgical treatment and research
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
abstract:PURPOSE:To identify the correlation of the model for end-stage liver disease (MELD) scores with the assessment of the risk of hepatic function after hemihepatectomy in patients with hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV). METHODS:A case-control study was performed based on data for 141 conse...
journal_title:Annals of surgical treatment and research
pub_type: 杂志文章
doi:10.4174/astr.2014.86.3.122
更新日期:2014-03-01 00:00:00
abstract:Purpose:Thyroid reoperations are surgically challenging because of significant anatomical variance. Visual and functional identification of the external branch of the superior laryngeal nerve (EBSLN) were studied in 2 groups of patients who underwent primary and redo thyroid surgery. Methods:This study was conducted o...
journal_title:Annals of surgical treatment and research
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更新日期:2019-06-01 00:00:00
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journal_title:Annals of surgical treatment and research
pub_type: 杂志文章
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abstract:Purpose:Tenofovir disoproxil fumarate is accepted as an effective and tolerable drug for treatment of HBV, similar to entecavir. However, there are some concerns about the nephrotoxicity of tenofovir. The aim of this study is to compare the renal-function change of liver recipients who received tenofovir or entecavir f...
journal_title:Annals of surgical treatment and research
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journal_title:Annals of surgical treatment and research
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更新日期:2017-12-01 00:00:00
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journal_title:Annals of surgical treatment and research
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更新日期:2016-03-01 00:00:00
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journal_title:Annals of surgical treatment and research
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更新日期:2019-05-01 00:00:00
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journal_title:Annals of surgical treatment and research
pub_type: 杂志文章
doi:10.4174/astr.2015.89.3.117
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:The aim of the present study was to identify the radiation hazards to vascular surgeons and scrub nurses working in mobile fluoroscopy equipped hybrid vascular operation rooms; additionally, to estimate cumulative cancer risk due to certain exposure dosages. METHODS:The study was conducted prospectively in 71 ...
journal_title:Annals of surgical treatment and research
pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Laparoscopic fundoplication is considered the standard surgical treatment for gastroesophageal reflux disease (GERD) in Western countries. However, some patients experience poor surgical outcomes with this procedure. The study aimed to identify the predictive factors of the surgical outcomes of laparoscopic Nis...
journal_title:Annals of surgical treatment and research
pub_type: 杂志文章
doi:10.4174/astr.2017.92.4.184
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:This study aimed to determine which factors affect the prognosis of hepatectomy for hepatocellular carcinoma (HCC) larger than 5 cm, including the prognostic difference between tumor sizes from 5-10 cm and larger than 10 cm. METHODS:The medical records of 114 patients who underwent hepatectomy for single HCC l...
journal_title:Annals of surgical treatment and research
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
abstract:Purpose:Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested whether quantification of urinary TG2 may represent a noninvasive method to estimate the severity of kidney allograft fibrosis. Methods:We prospectively collected urine specimens from ...
journal_title:Annals of surgical treatment and research
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
abstract:Purpose:Recent studies investigating new strategies to modulate the immune system have utilized animal models of liver transplantation (LT). However, the anhepatic phase (AHP) remains a crucial problem in LT. The aim of the present study is to introduce a technique for successful orthotopic LT in cynomolgus monkeys usi...
journal_title:Annals of surgical treatment and research
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更新日期:2018-01-01 00:00:00