Abstract：
PURPOSE:Severe local and systemic tissue damage called ischemia/reperfusion (IR) injury occurs during the period of reperfusion. Free oxygen radicals and proinflammatory cytokines are responsible for reperfusion injury. IL-18 binding protein (IL-18BP) is a natural inhibitor of IL-18. The balance between IL-18 and IL-18BP has an important role in the inflammatory setting. The present study aimed to investigate whether IL-18BP had a protective role in remote organ hepatic IR injury. METHODS:Wistar-Albino rats were divided into three groups that contained seven rats. Group I (sham): Laparotomy and infrarenal abdominal aorta (AA) dissection were done but no clamping was done. Group II (I/R): The infrarenal AA was clamped by atraumatic microvascular clamp for 30 minutes and then was exposed to 90 minutes of reperfusion. Group III (IR + IL-18BP): 75 µg/kg of IL-18BP in 0.9% saline (1 mL) was administered 30 minutes before infrarenal AA dissection and clamping; 30 minutes of ischemia was applied and then was exposed to 90 minutes of reperfusion. RESULTS:Serum AST, ALT, and LDH levels were remarkably higher in IR group and returned to normal levels in treatment group. The proinflammatory cytokine levels had decreased in treatment group, and was statistically significant compared with the IR group. Serum levels of total oxidant status and oxidative stress index decreased and levels of total antioxidant status increased by IL-18BP. CONCLUSION:This study suggested that IL-18BP has antioxidant, anti-inflammatory and hepatoprotective effects in cases of IR with infrarenal AA induced liver oxidative damage.
journal_name
Ann Surg Treat Resjournal_title
Annals of surgical treatment and researchauthors
Ozsoy M,Gonul Y,Bal A,Ozkececi ZT,Celep RB,Adali F,Hazman O,Koçak A,Tosun Mdoi
10.4174/astr.2015.88.2.92subject
Has Abstractpub_date
2015-02-01 00:00:00pages
92-9issue
2eissn
2288-6575issn
2288-6796journal_volume
88pub_type
杂志文章abstract：:Vitelline veins are a pair of embryonic structures. The veins develop the portal vein system. Serious problems occur if the vitelline vein does not regress and becomes an aneurysm. Thrombus formation in the vitelline vein aneurysm could lead to portal vein thrombosis and portal hypertension unless promptly and correct...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2015.89.6.334
更新日期：2015-12-01 00:00:00
abstract：Purpose:Thyroid reoperations are surgically challenging because of significant anatomical variance. Visual and functional identification of the external branch of the superior laryngeal nerve (EBSLN) were studied in 2 groups of patients who underwent primary and redo thyroid surgery. Methods:This study was conducted o...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2019.96.6.269
更新日期：2019-06-01 00:00:00
abstract：Purpose:Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested whether quantification of urinary TG2 may represent a noninvasive method to estimate the severity of kidney allograft fibrosis. Methods:We prospectively collected urine specimens from ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2019.97.1.27
更新日期：2019-07-01 00:00:00
abstract：PURPOSE:To identify the correlation of the model for end-stage liver disease (MELD) scores with the assessment of the risk of hepatic function after hemihepatectomy in patients with hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV). METHODS:A case-control study was performed based on data for 141 conse...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.86.3.122
更新日期：2014-03-01 00:00:00
abstract：PURPOSE:The aim of the present study was to identify the radiation hazards to vascular surgeons and scrub nurses working in mobile fluoroscopy equipped hybrid vascular operation rooms; additionally, to estimate cumulative cancer risk due to certain exposure dosages. METHODS:The study was conducted prospectively in 71 ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2017.92.3.156
更新日期：2017-03-01 00:00:00
abstract：PURPOSE:The aim of this study is to assess the long-term results of laparoscopic common bile duct exploration (LCBDE) and validate its effectiveness as a primary treatment modality for CBD stone. METHODS:A retrospective review of the medical records of 157 patients who underwent LCBDE from 1997 to 2011 was conducted. ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.86.1.1
更新日期：2014-01-01 00:00:00
abstract：Purpose:Laparoscopic antireflux surgery is not widely used in Korea, but published data suggest that its results are comparable to those of Western countries. The purpose of this study was to compare the clinical characteristics, medical utilization, and medical costs of antireflux surgery and proton pump inhibitor (PP...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2020.98.5.254
更新日期：2020-05-01 00:00:00
abstract：Purpose:Infection remains the main cause of morbidity and mortality in liver transplantation (LT) recipients; however infection is notoriously difficult to diagnose because its usual signs and symptoms of infection may be masked or absent. This study comprises an analysis of bacterial infections in the early period aft...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.94.3.154
更新日期：2018-03-01 00:00:00
abstract：:Gastrointestinal (GI) tract metastasis of primary breast cancer is very rare. We present a patient with small bowel obstruction from distant metastasis of primary breast cancer. Each characteristic features of concern of GI tract distant metastasis from many pervious studies has been reported differently. We should re...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2018.94.2.102
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:This study aimed to determine the mortality rate in patients with severe trauma and the risk factors for trauma mortality based on 3 years' data in a regional trauma center in Korea. METHODS:We reviewed the medical records of severe trauma patients admitted to Ajou University Hospital with an Injury Severity S...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.89.4.215
更新日期：2015-10-01 00:00:00
abstract：Purpose:Many patients with cytology proven node-positive breast cancer receive a neoadjuvant chemotherapy (NAC) treatment. We developed a nomogram to predict the breast and axillary pathologic complete responses (pCR) in patients with a cytologically proven axillary node positive breast cancer with NAC. Methods:We sel...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2019.96.4.169
更新日期：2019-04-01 00:00:00
abstract：Purpose:Tenofovir disoproxil fumarate is accepted as an effective and tolerable drug for treatment of HBV, similar to entecavir. However, there are some concerns about the nephrotoxicity of tenofovir. The aim of this study is to compare the renal-function change of liver recipients who received tenofovir or entecavir f...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2020.99.3.180
更新日期：2020-09-01 00:00:00
abstract：Purpose:Recent studies investigating new strategies to modulate the immune system have utilized animal models of liver transplantation (LT). However, the anhepatic phase (AHP) remains a crucial problem in LT. The aim of the present study is to introduce a technique for successful orthotopic LT in cynomolgus monkeys usi...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.94.1.8
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:Laparoscopic fundoplication is considered the standard surgical treatment for gastroesophageal reflux disease (GERD) in Western countries. However, some patients experience poor surgical outcomes with this procedure. The study aimed to identify the predictive factors of the surgical outcomes of laparoscopic Nis...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2017.92.4.184
更新日期：2017-04-01 00:00:00
abstract：Purpose:Preoperative chemoradiation therapy (CRT) has become the standard treatment for patients with locally advanced rectal cancer, 15%-30% of patients still progress while being treated with CRT. The aim of this study was to identify as important biomarker of poor response and evaluate the mechanism associated with ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2019.97.2.83
更新日期：2019-08-01 00:00:00
abstract：Purpose:A soft texture of the pancreas is one of the most important predisposing factors for a pancreatic fistula. Thus, in a porcine model, we investigated a method to harden the pancreas locally by directly injecting an artificial material. Methods:During the laparotomy, 51 samples from 17 pigs, including 13 surviva...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.95.4.175
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:Recently, the number of elderly patients has increased due to a longer life expectancy. Among these elderly patients, more octogenarians will be diagnosed with major hepatobiliary pancreatic (HBP) diseases. Therefore, we need to evaluate the safety and risk factors of major HBP surgery in patients older than 80...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.91.6.288
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:Bariatric surgery has become more prevalent owing to the worldwide obesity epidemic. With the growing number of bariatric procedures performed annually, the requirement for revisional and secondary operations is increasing accordingly. This study aimed to evaluate the initial experience of revisional bariatric ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.86.6.295
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:We evaluate the operative outcome and oncologic outcome of laparoscopic liver resection for hepatocellular carcinoma (HCC), and compare with open liver resection. METHODS:From January 2004 to December 2012, clinical data of 70 patients who underwent laparoscopic liver resection for HCC (laparoscopic liver rese...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2014.86.2.61
更新日期：2014-02-01 00:00:00
abstract：Purpose:Recently a controversy has arisen about so-called "ghost surgery" practices, and people have voiced their opinions for legal sanction against such practices, which clearly undermine the foundation of medical ethics. However, there has been a lack of legal basis for punishing those actions. The present study aim...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2018.94.4.167
更新日期：2018-04-01 00:00:00
abstract：:[This corrects the article on p. 396 in vol. 92, PMID: 28580343.]. ...
journal_title：Annals of surgical treatment and research
pub_type： 已发布勘误
doi：10.4174/astr.2017.93.2.118
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:This study aimed to determine which factors affect the prognosis of hepatectomy for hepatocellular carcinoma (HCC) larger than 5 cm, including the prognostic difference between tumor sizes from 5-10 cm and larger than 10 cm. METHODS:The medical records of 114 patients who underwent hepatectomy for single HCC l...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.91.3.104
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:Ultrasound-guided fine needle aspiration (US-FNA) in thyroid nodules is presently most commonly used to identify whether these nodules are benign or malignant. However, atypical or follicular lesions of undetermined significance (AUS/FLUS), as categorized in the Bethesda System for reporting the results of FNA,...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.90.4.201
更新日期：2016-04-01 00:00:00
abstract：PURPOSE:The 2-port laparoscopic appendectomy technique (TLA) is between the conventional 3-port and single-port laparoscopic appendectomy surgeries. We compared postoperative pain and cosmetic results after TLA with conventional laparoscopic appendectomy (CLA) by a 3-port device. METHODS:Patients undergoing TLA were m...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.91.2.59
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:We aimed to develop an effective system for surgical site infection (SSI) surveillance and examine the current domestic state of SSIs for common abdominal surgeries in Korea. METHODS:The Korean Surgical Site Infection Surveillance (KOSSIS) program was developed as an SSI surveillance system. A prospective mult...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.88.3.119
更新日期：2015-03-01 00:00:00
abstract：:Coil migration is an extremely rare but hazardous complication of aneurysmal coil embolization. Only 1 case report has described coil migration following endovascular exclusion to gastrointestinal (GI) tract. We report the experience of a case of colon penetration caused by embolization coil placed for internal iliac ...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2017.92.6.440
更新日期：2017-06-01 00:00:00
abstract：:We present the case of young female patient presenting with acute onset abdominal pain. Abdominopelvic CT revealed herniation through the foramen of Winslow. The patient was transferred to our hospital and underwent laparoscopic exploration. Though spontaneous reduction was detected, segmental resection of the impacte...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2017.92.2.113
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:Downstaging after chemoradiotherapy (CRT) for rectal cancer usually occurs. The present study aimed to evaluate pathologic y-stage (yp-stage) and its influence on local recurrence and systemic recurrence in rectal cancer patients treated with CRT followed by surgical resection. METHODS:We retrospectively analy...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2015.88.1.15
更新日期：2015-01-01 00:00:00
abstract：:Anastomotic leakage following rectal resection is a serious and fearful complication, and may cause presacral abscess and/or peritonitis. To our knowledge, massive hematochezia secondary to presacral abscess caused by anastomotic leakage has not yet been reported in the literature. We observed this rare and life-threa...
journal_title：Annals of surgical treatment and research
pub_type：
doi：10.4174/astr.2015.88.4.236
更新日期：2015-04-01 00:00:00
abstract：PURPOSE:The factors related to early-onset tumor recurrence in patients with spontaneously ruptured hepatocellular carcinoma (HCC) after hepatectomy remain unclear. The aims of the present study were to compare characteristics between early and late recurrence groups in spontaneously ruptured HCC patients who received ...
journal_title：Annals of surgical treatment and research
pub_type： 杂志文章
doi：10.4174/astr.2016.91.1.17
更新日期：2016-07-01 00:00:00
