Morphological and functional effects of Na2EDTA on the outflow routes for aqueous humor in monkeys.

abstract：:It has been reported that chymase activity was increased in allergic conjunctivitis patients and this activity was correlated with the severity of the disease. However, the precise roles of chymase in allergic conjunctivitis are unclear, and whether chymase inhibitors are effective for allergic conjunctivitis has not ...

journal_title：Experimental eye research

authors： Nabe T,Kijitani Y,Kitagawa Y,Sakano E,Ueno T,Fujii M,Nakao S,Sakai M,Takai S

更新日期：2013-08-01 00:00:00

abstract：:γ-secretase inhibitor has been shown to promote intestinal goblet cell differentiation. We now demonstrated that the in vitro addition of γ-secretase inhibitor in the culture of human conjunctival epithelial cells significantly promoted the differentiation of conjunctival goblet cells with typical droplet-like phenoty...

journal_title：Experimental eye research

authors： Tian L,Qu M,Wang Y,Duan H,Di G,Xie L,Zhou Q

更新日期：2014-06-01 00:00:00

abstract：:By methods of subtraction-hybridization of lambda ZAP cDNA libraries, prepared from 4-week-old rat lens epithelial cells (capsule) and lens fiber cells (decapsulated lens), we have isolated a specific cDNA clone whose target mRNA is about 600 b long. Northern blot hybridization analysis data showed that the target mRN...

journal_title：Experimental eye research

authors： Wen Y,Li GW,Chen P,Bekhor I

更新日期：1995-06-01 00:00:00

abstract：:Dietary restriction can effectively extend lifespan and retard many age-related debilities. One hypothesis to explain the beneficial effects of dietary restriction is that it prolongs maintenance of cellular homeostasis by limiting endogenous oxidative stress and preserves oxidative defense mechanisms during aging. As...

journal_title：Experimental eye research

authors： Taylor A,Jahngen-Hodge J,Smith DE,Palmer VJ,Dallal GE,Lipman RD,Padhye N,Frei B

更新日期：1995-07-01 00:00:00

abstract：:Infection of the corneal endothelial cells by human cytomegalovirus (CMV) is an important cause of corneal endotheliitis. CMV endotheliitis is difficult to completely cure and relapses are frequent. This can cause blinding corneal bullous keratopathy. However, the pathogenesis of CMV endotheliitis remains undetermined...

journal_title：Experimental eye research

authors： Miyazaki D,Uotani R,Inoue M,Haruki T,Shimizu Y,Yakura K,Yamagami S,Suzutani T,Hosogai M,Isomura H,Inoue Y

更新日期：2017-08-01 00:00:00

abstract：:This study demonstrates post-translational arginylation of bovine serum albumin and endogenous lens proteins by bovine lens arginyl-tRNA:protein transferase. This reaction has been proposed to be the first step in marking specific proteins for degradation by the non-lysosomal, ATP-dependent, ubiquitin-mediated proteol...

journal_title：Experimental eye research

authors： Wagner BJ,Margolis JW

更新日期：1991-11-01 00:00:00

abstract：:Addition of substance P (10(-7) to 10(-6) M) to rabbit iris sphincter muscle induced: (a) a rapid phosphodiesteratic breakdown of phosphatidylinositol 4,5-bisphosphate (PIP2) into 1,2-diacylglycerol (DG), measured as phosphatidic acid, and inositol triphosphate (IP3), measured by anion-exchange chromatography; (b) a r...

journal_title：Experimental eye research

authors： Yousufzai SY,Akhtar RA,Abdel-Latif AA

更新日期：1986-08-01 00:00:00

abstract：:Neovascular age-related macular degeneration (AMD) is a leading cause of vision loss worldwide. Although intravitreal injection of anti-VEGF antibodies and VEGF Trap have significant clinical benefits, the complications of intravitreal injection, drug resistance and patient compliance still need to be concerned. In th...

journal_title：Experimental eye research

authors： Wei X,Zhang T,Yao Y,Zeng S,Li M,Xiang H,Zhao C,Cao G,Li M,Wan R,Yang P,Yang J

更新日期：2018-03-01 00:00:00

abstract：:Two-dimensional 1H NMR spectroscopic studies are presented on bovine gamma S- and gamma B-crystallin. In gamma S-crystallin, the four N-terminal residues have great flexibility compared with the rest of the molecule and assume a random coil conformation. NMR spectroscopy and electrospray mass spectrometry show that th...

journal_title：Experimental eye research

authors： Cooper PG,Carver JA,Aquilina JA,Ralston GB,Truscott RJ

更新日期：1994-08-01 00:00:00

abstract：:Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural...

journal_title：Experimental eye research

authors： Jones BW,Marc RE

更新日期：2005-08-01 00:00:00

abstract：:Conjunctival impression cytology samples from patients with meibomian gland dysfunction (MGD), dry eye (DE), and healthy subjects (CT) were collected for determination of the degree of squamous metaplasia (SM) by PAS-hematoxylin staining and for comparative proteomic analyses by 2D-DIGE. The protein spots with discrim...

journal_title：Experimental eye research

authors： Soria J,Acera A,Durán JA,Boto-de-Los-Bueis A,Del-Hierro-Zarzuelo A,González N,Reigada R,Suárez T

更新日期：2018-02-01 00:00:00

abstract：:This review describes our recent attempts to develop new therapeutic modalities for corneal endothelial disease using animal models including non-human primate model in which the proliferative ability of corneal endothelial cells is severely limited, as is the case in humans. First, we describe our attempt to develop ...

journal_title：Experimental eye research

authors： Koizumi N,Okumura N,Kinoshita S

更新日期：2012-02-01 00:00:00

abstract：:The mass receptor potential of the excised, superfused retina of the bullfrog was studied. Photoreceptor responses were isolated by addition of sodium aspartate to the Ringer solutions. Responses of the cones were monitored independently from responses of the rods by employing a two-flash method of stimulation which t...

journal_title：Experimental eye research

authors： Sillman AJ,Bolnick DA,Bosettii JB,Haynes LW,Walter AE

更新日期：1984-08-01 00:00:00

abstract：:The corneal endothelium of man, primates and carnivores has limited regenerative ability. Fibroblast growth factor (FGF) stimulates the proliferation of various mesoderm-derived cells, including corneal endothelial cells, in vitro. In the present work the effect of FGF on the regeneration of injured cat endothelium in...

journal_title：Experimental eye research

authors： Landshman N,Belkin M,Ben-Hanan I,Ben-Chaim O,Assia E,Savion N

更新日期：1987-12-01 00:00:00

abstract：:Microaneurysms, acellular capillaries and pericyte ghosts are characteristic of diabetic retinopathy, but it is not clear what causes these lesions or whether they are causally related to each other. The distribution of microaneurysms, acellular capillaries and pericyte ghosts has been evaluated in two animal models o...

journal_title：Experimental eye research

authors： Kern TS,Engerman RL

更新日期：1995-05-01 00:00:00

abstract：:The purpose of this study was to investigate the influence of molecular shape, conformability, net surface charge and tissue interaction on transscleral diffusion. Unfixed, porcine sclera was clamped in an Ussing chamber. Fluorophore-labelled neutral albumin, neutral dextran, or neutral ficoll were placed in one hemi-...

journal_title：Experimental eye research

authors： Srikantha N,Mourad F,Suhling K,Elsaid N,Levitt J,Chung PH,Somavarapu S,Jackson TL

更新日期：2012-09-01 00:00:00

abstract：:Utilizing cultured lenses from normal and homozygous glutathione peroxidase (GSHPx-1) knockout mice and inhibitors for GSSG Reductase (GSSG Red), 1,3-bis(2-chlorethyl)-1-nitrosourea (BCNU) and catalase (Cat), 3-aminotriazole (3-AT), the ability to degrade H2O2 was examined at two H2O2 concentrations, 300 microM and 80...

journal_title：Experimental eye research

authors： Spector A,Ma W,Wang RR,Yang Y,Ho YS

更新日期：1997-03-01 00:00:00

abstract：:We developed an approach to generate a three-dimensional map that facilitates the assessment of epithelial nerve density in different corneal areas to define aging and gender influence on human corneal nerve architecture. Twenty-eight fresh human eyes from 14 donors of different ages were studied. Corneal nerves were ...

journal_title：Experimental eye research

authors： He J,Bazan NG,Bazan HE

更新日期：2010-10-01 00:00:00

abstract：:Anatomic and physiological barriers limit drug delivery to the posterior segment of the eye via topical or systemic administration. Intravitreal administration has proven to be a safe and effective means of treating various posterior segment diseases. Elimination of a compound from the vitreous chamber may depend on l...

journal_title：Experimental eye research

authors： Atluri H,Mitra AK

更新日期：2003-03-01 00:00:00

abstract：:The distribution of collagen degradation and synthesis (turnover) between the central and peripheral areas of clear corneal allografts was determined, following transplantation of 6-mm [3H]proline-labelled corneal buttons from extensively pre-labelled, young rabbits into 13 nonradioactive mature rabbits. Control, cont...

journal_title：Experimental eye research

authors： Lass JH,Baker DS,Klein LR

更新日期：1987-07-01 00:00:00

abstract：:The aim of this study was to optimize non-viral gene transfer conditions and investigate the effect of fibroblast growth factor-1 (FGF-1) gene transfer on human corneal endothelial cell (HCEC) proliferation. Five non-viral vectors (Lipofectin, DMRIE-C, DAC-30, Effectene, FuGene6) were used to transfect HCEC with plasm...

journal_title：Experimental eye research

authors： Dannowski H,Bednarz J,Reszka R,Engelmann K,Pleyer U

更新日期：2005-01-01 00:00:00

abstract：:Photoreceptor cell pathology was investigated in an 8-yr-old mixed-breed dog which had displayed visual symptoms of 1 month duration. An electroretinogram detected no light-evoked responses. Light and electron microscopic features showed marked thinning and atrophy of the outer both the tapetal and non-tapetal retina ...

journal_title：Experimental eye research

authors： Wiechmann AF,Font RL,Hollyfield JG

更新日期：1991-03-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA)-induced excitotoxicity is an acute form of experimental retinal injury as a result of overactivation of glutamate receptors. NLRP3 (nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain containing-3) inflammasome, one of the most studied sensors of innate immunity, ...

journal_title：Experimental eye research

authors： Tsoka P,Barbisan PR,Kataoka K,Chen XN,Tian B,Bouzika P,Miller JW,Paschalis EI,Vavvas DG

更新日期：2019-04-01 00:00:00

abstract：:The relative distribution of acetylcholine (ACh) receptors on the surface of the isolated ocular lens of the rabbit was determined from induced changes in translens short-circuit current (I(SC)) and the translenticular resistance (R(t)) at seven delineated, parallel zones from the anterior to the posterior pole. For t...

journal_title：Experimental eye research

authors： Candia OA,Zamudio AC,Polikoff LA,Alvarez LJ

更新日期：2002-06-01 00:00:00

abstract：:cDNA clones encoding S-antigen (arrestin) were isolated from the expression library constructed from porcine retina and sequenced. The 1490 base pair fragment contained a 1215 base pair open reading frame. From the nucleotide sequence, an amino acid sequence consisting of 405 residues was deduced and a molecular mass ...

journal_title：Experimental eye research

authors： Singh AK,Kumar G,Shinohara T,Shichi H

更新日期：1996-03-01 00:00:00

abstract：:Stromal transparency is a critical factor contributing to normal function of the visual system. Corneal injury, surgery, disease and infection elicit complex wound healing responses that serve to protect against insults and maintain the integrity of the cornea, and subsequently to restore corneal structure and transpa...

journal_title：Experimental eye research

authors： Torricelli AA,Wilson SE

更新日期：2014-12-01 00:00:00

abstract：:A shift or displacement of the retinal blood vessels (RBVs) with neuroretinal rim thinning indicates the progression of glaucomatous optic neuropathy. In chronic open angle glaucoma, individuals with RBV positional shifts exhibit more rapid visual field loss than those without RBV shifts. The retinal vessels reportedl...

journal_title：Experimental eye research

authors： Kuroda A,Enomoto N,Ishida K,Shimazawa M,Noguchi T,Horai N,Onoe H,Hara H,Tomita G

更新日期：2017-09-01 00:00:00

abstract：:Prolyl oligopeptidase (EC 3.4.21.26) has been purified 26,000-fold from bovine lens tissue by anion-exchange chromatography, gel filtration and isoelectric focussing, with an overall yield of 11%. The purified enzyme exhibited an isoelectric point of 4.8, a pH optimum of 7.5 and a molecular mass of 72 kDa under both n...

journal_title：Experimental eye research

authors： Sharma KK,Ortwerth BJ

更新日期：1994-07-01 00:00:00

abstract：:SPARC (secreted protein acidic and rich in cysteine) is a matricellular protein that regulates cellular adhesion and proliferation. In this report, we show that SPARC protein is restricted to epithelial cells of the murine lens and ends abruptly at the equatorial bow region where lens fiber differentiation begins. SPA...

journal_title：Experimental eye research

authors： Bassuk JA,Birkebak T,Rothmier JD,Clark JM,Bradshaw A,Muchowski PJ,Howe CC,Clark JI,Sage EH

更新日期：1999-03-01 00:00:00

abstract：:It has been suggested that ambient lighting at night influences eye growth and might play a causal role in human myopia. To test this hypothesis, we reared newly hatched chicks under 12 hr light-dark or light-dim cycles with a light phase intensity of 1500 microW/cm(2) and variable dim phase intensities between 0.01 a...

journal_title：Experimental eye research

authors： Liu J,Pendrak K,Capehart C,Sugimoto R,Schmid GF,Stone RA

更新日期：2004-11-01 00:00:00