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Knee osteoarthritis risk is increased 4-6 fold after knee injury - a systematic review and meta-analysis.

Abstract：

OBJECTIVE:To estimate knee osteoarthritis (OA) risk following anterior cruciate ligament (ACL), meniscus or combined ACL and meniscus injury. DESIGN:Systematic review and meta-analysis. DATA SOURCES:MEDLINE, Embase, SPORTDiscus, CINAHL and Web of Science until November 2018. ELIGIBILITY CRITERIA FOR SELECTING STUDIES:Prospective or retrospective studies with at least 2-year follow-up including adults with ACL injury, meniscal injury or combined injuries. Knee OA was defined by radiographs or clinical diagnosis and compared with the contralateral knee or non-injured controls. STUDY APPRAISAL AND SYNTHESIS:Risk of bias was assessed using the SIGN50 checklist. ORs for developing knee OA were estimated using random effects meta-analysis. RESULTS:53 studies totalling ∼1 million participants were included: 185 219 participants with ACL injury, mean age 28 years, 35% females, 98% surgically reconstructed; 83 267 participants with meniscal injury, mean age 38 years, 36% females, 22% confirmed meniscectomy and 73% unknown; 725 362 participants with combined injury, mean age 31 years, 26% females, 80% treated surgically. The OR of developing knee OA were 4.2 (95% CI 2.2 to 8.0; I2=92%), 6.3 (95% CI 3.8 to 10.5; I2=95%) and 6.4 (95% CI 4.9 to 8.3; I2=62%) for patients with ACL injury, meniscal injury and combined injuries, respectively. CONCLUSION:The odds of developing knee OA following ACL injury are approximately four times higher compared with a non-injured knee. A meniscal injury and a combined injury affecting both the ACL and meniscus are associated with six times higher odds compared with a non-injured knee. Large inconsistency (eg, study design, follow-up period and comparator) and few high-quality studies suggest that future studies may change these estimates. CLINICAL RELEVANCE:Patients sustaining a major knee injury have a substantially increased risk of developing knee OA, highlighting the importance of knee injury prevention programmes and secondary prevention strategies to prevent or delay knee OA development.PROSPERO registration number CRD42015016900.

journal_name

Br J Sports Med

journal_title

British journal of sports medicine

authors

Poulsen E,Goncalves GH,Bricca A,Roos EM,Thorlund JB,Juhl CB

doi

10.1136/bjsports-2018-100022

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1454-1463

issue

eissn

0306-3674

issn

1473-0480

pii

bjsports-2018-100022

journal_volume

pub_type

杂志文章,meta分析

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Knee osteoarthritis risk is increased 4-6 fold after knee injury - a systematic review and meta-analysis.