Abstract：
:Bacterial virulence is controlled by a cascade of genes influenced by quorum sensing alias bacterial signalling.The present study was intended to develop an effective module that could constrain bacterial communication without harming the host. Quorum quenching ability of Tribulus terrestris was screened upon chromogenic reporter strains such as Chromobacterium violaceum, Serratia marcescens and Pseudomonas aeruginosa. Hydro-alcoholic extracts of root showed positive quorum quenching activity by effectively down regulating quorum sensing controlled mechanisms such as pigment production and biofilm formation. Lead component was purified and found to be ß-1, 5-O-dibenzoyl ribofuranose by GC-MS NIST and NMR spectrometry. Interestingly it was observed that the compound was neither bactericidal nor bacteriostatic but rather it's only disturbing its interaction. Further studies revealed that the antagonist is not inhibiting the production of signalling molecule acyl homoserine lactone, instead inhibiting its action.
journal_name
3 Biotechjournal_title
3 Biotechauthors
Vadakkan K,Vijayanand S,Hemapriya J,Gunasekaran Rdoi
10.1007/s13205-019-1695-7subject
Has Abstractpub_date
2019-04-01 00:00:00pages
163issue
4eissn
2190-572Xissn
2190-5738pii
1695journal_volume
9pub_type
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