Abstract：
:This study was aimed at investigating the phytochemical constituents, antifungal properties and antibiotic-modifying activity of the aqueous crude extract and fractions of Amburana cearensis seeds (CEFAC). The CEFAC were chemically characterized by LC-MS/MS-QTOF. In addition, the antifungal activity was assayed by the microdilution method against strains of Candida albicans. The phytochemical profile of CEFAC exhibited phenolic compounds, organic acids, and polyphenols. The results of the assessment of antifungal activity reveled an IC50 ranging from 45.6 to 2048 µg/mL. Interestingly, when CEFAC was associated with Fluconazole, we evidenced a decreased IC50 (1.81-11.9 µg/mL), suggesting a synergism with antibiotic. It was possible to identify in the crude extract and fractions several phenolic compounds, organic acids, and some polyphenols in positive ionization mode. These results suggest that CEFAC may present compounds with the ability to interact and act synergistically with antimicrobial drugs, highlighting its potential as an alternative source for the development of new antimicrobial agents.
journal_name
3 Biotechjournal_title
3 Biotechauthors
Oliveira MTA,de Alencar MVOB,de Paulo Dos Anjos Landim V,Moura GMM,da Cruz JIO,Dos Santos EA,Coutinho HDM,Andrade JC,de Menezes IRA,Ribeiro PRV,de Brito ES,de Sousa EO,Uchoa AFdoi
10.1007/s13205-020-02551-4subject
Has Abstractpub_date
2020-12-01 00:00:00pages
545issue
12eissn
2190-572Xissn
2190-5738pii
2551journal_volume
10pub_type
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