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Investigation of multiple-dynein transport of melanosomes by non-invasive force measurement using fluctuation unit χ.

Abstract：

:Pigment organelles known as melanosomes disperse or aggregate in a melanophore in response to hormones. These movements are mediated by the microtubule motors kinesin-2 and cytoplasmic dynein. However, the force generation mechanism of dynein, unlike that of kinesin, is not well understood. In this study, to address this issue, we investigated the dynein-mediated aggregation of melanosomes in zebrafish melanophores. We applied the fluctuation theorem of non-equilibrium statistical mechanics to estimate forces acting on melanosomes during transport by dynein, given that the energy of a system is related to its fluctuation. Our results demonstrate that multiple force-producing units cooperatively transport a single melanosome. Since the force is generated by dynein, this suggests that multiple dyneins carry a single melanosome. Cooperative transport has been reported for other organelles; thus, multiple-motor transport may be a universal mechanism for moving organelles within the cell.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Hasegawa S,Sagawa T,Ikeda K,Okada Y,Hayashi K

doi

10.1038/s41598-019-41458-w

subject

Has Abstract

pub_date

2019-03-25 00:00:00

pages

5099

issue

1

issn

2045-2322

pii

10.1038/s41598-019-41458-w

journal_volume

9

pub_type

杂志文章

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