相关文献
NATURE文献大全abstract::The growth and differentiation of cytolytic T lymphocytes (CTL) is regulated by soluble growth hormones, of which interleukin-2 (IL-2) is considered to be of prime importance. Here we report that the lymphokine B-cell stimulatory factor (BSF-1 or interleukin-4) also has profound effects on the generation of these func...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326795a0
更新日期:1987-04-23 00:00:00
abstract::Melanocytes are phenotypically prominent but histologically inconspicuous skin cells. They are responsible for the pigmentation of skin and hair, and thereby contribute to the appearance of skin and provide protection from damage by ultraviolet radiation. Pigmentation mutants in various species are highly informative ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature05660
更新日期:2007-02-22 00:00:00
abstract::Mammalian telomeres repress DNA-damage activation at natural chromosome ends by recruiting specific inhibitors of the DNA-damage machinery that form a protective complex termed shelterin. Within this complex, TRF2 (also known as TERF2) has a crucial role in end protection through the suppression of ATM activation and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11873
更新日期:2013-02-28 00:00:00
abstract::A paramutation is an epigenetic interaction between two alleles of a locus, through which one allele induces a heritable modification in the other allele without modifying the DNA sequence. The paramutated allele itself becomes paramutagenic, that is, capable of epigenetically converting a new paramutable allele. Here...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11416
更新日期:2012-10-04 00:00:00
abstract::The RNA polymerase elongation complex (EC) is both highly stable and processive, rapidly extending RNA chains for thousands of nucleotides. Understanding the mechanisms of elongation and its regulation requires detailed information about the structural organization of the EC. Here we report the 2.5-A resolution struct...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05932
更新日期:2007-07-12 00:00:00
abstract::High-temperature superconductivity is achieved by doping copper oxide insulators with charge carriers. The density of carriers in conducting materials can be determined from measurements of the Hall voltage--the voltage transverse to the flow of the electrical current that is proportional to an applied magnetic field....
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01890
更新日期:2003-08-21 00:00:00
abstract::An increasing body of evidence points to mitochondrial dysfunction as a contributor to the molecular pathogenesis of neurodegenerative diseases such as Parkinson's disease. Recent studies of the Parkinson's disease associated genes PINK1 (ref. 2) and parkin (PARK2, ref. 3) indicate that they may act in a quality contr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12748
更新日期:2013-12-12 00:00:00
abstract::The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despite an A + T content of nearly 80%, the chromosome codes for 2,799 predicted protein coding genes and 73 tran...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00847
更新日期:2002-07-04 00:00:00
abstract::Silbo Gomero is a whistled language that is a rare and endangered surrogate of Spanish, used by shepherds on the island of La Gomera in the Canary Islands for communication over long distances on difficult terrain. Here we show that areas of the brain normally associated with spoken-language function are also activate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/433031a
更新日期:2005-01-06 00:00:00
abstract::The enkephalins Met-enkephalin and Leu-enkephalin were first isolated from porcine brain by Hughes and co-workers. We have recently isolated from bovine adrenals another enkephalin with the structure Tyr-Gly-Gly-Phe-Met-Arg-Phe, or Met-enkephalin-Arg6-Phe7 (ref. 2). We report here that this new heptapeptide is found i...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/288088a0
更新日期:1980-11-06 00:00:00
abstract::Rapid warming over the past 50 years on the Antarctic Peninsula is associated with the collapse of a number of ice shelves and accelerating glacier mass loss. In contrast, warming has been comparatively modest over West Antarctica and significant changes have not been observed over most of East Antarctica, suggesting ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature11391
更新日期:2012-09-06 00:00:00
abstract::The interplay between magnetic fields and interacting particles can lead to exotic phases of matter that exhibit topological order and high degrees of spatial entanglement. Although these phases were discovered in a solid-state setting, recent innovations in systems of ultracold neutral atoms-uncharged atoms that do n...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22811
更新日期:2017-06-21 00:00:00
abstract::The proton-activated chloride channel (PAC) is active across a wide range of mammalian cells and is involved in acid-induced cell death and tissue injury1-3. PAC has recently been shown to represent a novel and evolutionarily conserved protein family4,5. Here we present two cryo-electron microscopy structures of human...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2875-7
更新日期:2020-12-01 00:00:00
abstract::Complementary DNA cloning of the transcripts of the Drosophila clock gene period reveals three distinct transcripts. These result from unusual splicing pathways, one involving a CG 3' splice site and one resulting in the use of two different reading frames in one exon, and they predict three separate proteins. Two of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326042a0
更新日期:1987-03-05 00:00:00
abstract::The observation of the superfluid to Mott insulator phase transition of ultracold atoms in optical lattices was an enabling discovery in experimental many-body physics, providing the first tangible example of a quantum phase transition (one that occurs even at zero temperature) in an ultracold atomic gas. For a trappe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08244
更新日期:2009-08-20 00:00:00
abstract::Biological dinitrogen fixation provides the largest input of nitrogen to the oceans, therefore exerting important control on the ocean's nitrogen inventory and primary productivity. Nitrogen-isotope data from ocean sediments suggest that the marine-nitrogen inventory has been balanced for the past 3,000 years (ref. 4)...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11338
更新日期:2012-08-16 00:00:00
abstract::Dehydration embrittlement has been proposed to explain both intermediate- and deep-focus earthquakes in subduction zones. Because such earthquakes primarily occur at shallow depths or within the core of the subducting plate, dehydration at relatively low temperatures has been emphasized. However, recent careful reloca...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02475
更新日期:2004-04-08 00:00:00
abstract::Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12504
更新日期:2013-09-05 00:00:00
abstract::Human activities are causing Earth's sixth major extinction event-an accelerating decline of the world's stocks of biological diversity at rates 100 to 1,000 times pre-human levels. Historically, low-impact intrusion into species habitats arose from local demands for food, fuel and living space. However, in today's in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11145
更新日期:2012-06-06 00:00:00
abstract::Inhibitory neurotransmission mediated by GABA(A) receptors can be modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone. Neurosteroids are synthesized de novo in the brain during stress, pregnancyand after ethanol consumption, and disrupted steroid regulation of GABAergic trans...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05324
更新日期:2006-11-23 00:00:00
abstract::Plasticity in neural circuits can result from alterations in synaptic strength or connectivity, as well as from changes in the excitability of the neurons themselves. To better understand the role of plasticity in the brain, we need to establish how brain circuits work and the kinds of computations that different circ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature03011
更新日期:2004-10-14 00:00:00
abstract::Transmembrane channels and pores have key roles in fundamental biological processes1 and in biotechnological applications such as DNA nanopore sequencing2-4, resulting in considerable interest in the design of pore-containing proteins. Synthetic amphiphilic peptides have been found to form ion channels5,6, and there h...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2646-5
更新日期:2020-09-01 00:00:00
abstract::The clinical course of autoimmune and infectious disease varies greatly, even between individuals with the same condition. An understanding of the molecular basis for this heterogeneity could lead to significant improvements in both monitoring and treatment. During chronic infection the process of T-cell exhaustion in...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14468
更新日期:2015-07-30 00:00:00
abstract::In animals, maternal gene products deposited into eggs regulate embryonic development before activation of the zygotic genome. In plants, an analogous period of prolonged maternal control over embryogenesis is thought to occur based on some gene-expression studies. However, other gene-expression studies and genetic an...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10756
更新日期:2012-01-22 00:00:00
abstract::RNase P is the only endonuclease responsible for processing the 5' end of transfer RNA by cleaving a precursor and leading to tRNA maturation. It contains an RNA component and a protein component and has been identified in all organisms. It was one of the first catalytic RNAs identified and the first that acts as a mu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01386
更新日期:2003-02-13 00:00:00
abstract::Neuronal dendrites are electrically excitable: they can generate regenerative events such as dendritic spikes in response to sufficiently strong synaptic input. Although such events have been observed in many neuronal types, it is not well understood how active dendrites contribute to the tuning of neuronal output in ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12600
更新日期:2013-11-07 00:00:00
abstract::Metastasis is the main cause of death in people with cancer. To colonize distant organs, circulating tumour cells must overcome many obstacles through mechanisms that we are only now starting to understand. These include infiltrating distant tissue, evading immune defences, adapting to supportive niches, surviving as ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature17038
更新日期:2016-01-21 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-019-00588-x
更新日期:2019-02-01 00:00:00
abstract::The structural components involved in transduction of extracellular signals as diverse as a photon of light impinging on the retina or a hormone molecule impinging on a cell have been highly conserved. These components include a recognition unit or receptor (for example, the beta-adrenergic receptor (beta AR) for cate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/321869a0
更新日期:1986-06-26 00:00:00
abstract::We have used in vitro mutagenesis to identify a DNA sequence that is required for glucose regulation of the ADR2 locus of Saccharomyces cerevisiae. This region, located between 200 and 1,000 base pairs upstream of the structural gene for ADH II, has been identified by genetic and biochemical analysis as the site of AD...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/300724a0
更新日期:1982-12-23 00:00:00