Abstract:
:We studied and compared the nucleolar expression or nucleoli from specific bivalents in spermatocytes of the standard Mus musculus domesticus 2n=40, of Robertsonian (Rb) homozygotes 2n = 24 and heterozygotes 2n = 32. We analyzed 200 nuclear microspreads of each specific nucleolar chromosome and spermatocyte karyotype, using FISH to identify specific nucleolar bivalents, immunofluorescence for both fibrillarin of the nucleolus and the synaptonemal complex of the bivalents, and DAPI for heterochromatin. There was nucleolar expression in all the chromosomal conditions studied. By specific nucleolar bivalent, the quantitative relative nucleolar expression was higher in the bivalent 12 than in its derivatives, lower in the bivalent 15 than in its derivatives and higher in the bivalent 16 than its Rb derivatives. In the interactions between non-homologous chromosomal domains, the nucleolar bivalents were preferentially associated through pericentromeric heterochromatin with other bivalents of similar morphology and sometimes with other nucleolar bivalents. We suggest that the nucleolar expression in Rb nucleolar chromosomes is modified as a consequence of different localization of ribosomal genes (NOR) in the Rb chromosomes, its proximity to heterochromatin and its associations with chromosomes of the same morphology.
journal_name
Genes (Basel)journal_title
Genesauthors
López-Moncada F,Tapia D,Zuñiga N,Ayarza E,López-Fenner J,Redi CA,Berríos Sdoi
10.3390/genes10020120subject
Has Abstractpub_date
2019-02-06 00:00:00issue
2issn
2073-4425pii
genes10020120journal_volume
10pub_type
杂志文章相关文献
Genes文献大全abstract::Epigenetic modifications are a mechanism conveying environmental information to subsequent generations via parental germ lines. Research on epigenetic responses to environmental changes in wild mammals has been widely neglected, as well as studies that compare responses to changes in different environmental factors. H...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10010004
更新日期:2018-12-21 00:00:00
abstract::The dog population of Southern East Asia is unique in harboring virtually the full range of the universal mtDNA gene pool, and consequently, it has the highest genetic diversity worldwide. Despite this, limited research has been performed on dog genetics within this region. Here we present the first comprehensive stud...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11030253
更新日期:2020-02-27 00:00:00
abstract::The obligately anaerobic haloalkaliphilic bacterium Alkalitalea saponilacus can use xylan as the sole carbon source and produce propionate as the main fermentation product. Using mixed carbon sources of 0.4% (w/v) sucrose and 0.1% (w/v) birch xylan, xylanase production from A. saponilacus was 3.2-fold greater than tha...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10010001
更新日期:2018-12-20 00:00:00
abstract::Dicentric chromosomes are a relevant marker of chromosomal instability. Their appearance is associated with telomere dysfunction, leading to cancer progression and a poor clinical outcome. Here, we present Telomere and Centromere staining followed by M-FISH (TC+M-FISH) for improved detection of telomere dysfunction an...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050475
更新日期:2020-04-27 00:00:00
abstract::The large phenotypic variation in the olfactory bulb may be related to heterogeneity in the progenitor cells. Accordingly, the progeny of subventricular zone (SVZ) progenitor cells that are destined for the olfactory bulb is of particular interest, specifically as there are many facets of these progenitors and their m...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11030305
更新日期:2020-03-13 00:00:00
abstract::Shewanella oneidensis MR-1 can transfer electrons from the intracellular environment to the extracellular space of the cells to reduce the extracellular insoluble electron acceptors (Extracellular Electron Transfer, EET). Benefiting from this EET capability, Shewanella has been widely used in different areas, such as ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9010041
更新日期:2018-01-16 00:00:00
abstract::Oral clefts are composed of cleft of the lip, cleft of the lip and palate, or cleft of the palate, and they are associated with a wide range of expression and severity. When cleft of the palate is associated with cleft of the lip with preservation of the primary palate, it defines an atypical phenotype called disconti...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10100833
更新日期:2019-10-22 00:00:00
abstract::Pyrethroid resistance in major malaria vectors such as Anopheles funestus threatens malaria control efforts in Africa. Cytochrome P450-mediated metabolic resistance is best understood for CYP6P9 genes in southern Africa in An. funestus. However, we do not know if this resistance mechanism is spreading across Africa an...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111314
更新日期:2020-11-05 00:00:00
abstract::MYO6 is known as a genetic cause of autosomal dominant and autosomal recessive inherited hearing loss. In this study, to clarify the frequency and clinical characteristics of hearing loss caused by MYO6 gene mutations, a large-scale genetic analysis of Japanese patients with hearing loss was performed. By means of mas...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11030273
更新日期:2020-03-04 00:00:00
abstract::Repetitive DNA including tandem repeats (TRs) is a significant part of most eukaryotic genomes. TRs include rapidly evolving satellite DNA (satDNA) that can be shared by closely related species, their abundance may be associated with evolutionary divergence, and they have been widely used for chromosome karyotyping us...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10020113
更新日期:2019-02-01 00:00:00
abstract::Hypertrophic cardiomyopathy associated with damaging variants in the ALPK3 gene is a fairly recent discovery, and only a small number of patients have been described thus far. Here we present two additional patients with hypertrophic cardiomyopathy caused by biallelic variants in ALPK3. Genetic investigation was perfo...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101201
更新日期:2020-10-15 00:00:00
abstract::Sarcomas are highly aggressive cancers that have a high propensity for metastasis, fail to respond to conventional therapies, and carry a poor 5-year survival rate. This is particularly true for patients with neurofibromatosis type 1 (NF1), in which 8%-13% of affected individuals will develop a malignant peripheral ne...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11050499
更新日期:2020-05-01 00:00:00
abstract::Blumeria graminis f. sp. hordei (Bgh), the causal agent of barley powdery mildew (PM), is one of the most important barley leaf diseases and is prevalent in most barley growing regions. Infection decreases grain quality and yields on average by 30%. Multi-parent advanced generation inter-cross (MAGIC) populations comb...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11121512
更新日期:2020-12-18 00:00:00
abstract::During the evolution of heteromorphic sex chromosomes, the sex-specific Y chromosome degenerates, while the X chromosome evolves new mechanisms of regulation. Using bioinformatic and experimental approaches, we investigate the expression of the X chromosome in Drosophila melanogaster. We observe nearly complete X chro...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9050242
更新日期:2018-05-04 00:00:00
abstract::Bone mineral density (BMD) is of concern in Prader-Willi syndrome (PWS). This study compared responses to a physical activity intervention in bone parameters and remodeling markers in youth with PWS (n = 45) and youth with non-syndromic obesity (NSO; n = 66). Measurements occurred at baseline (PRE) and after 24 weeks ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11090984
更新日期:2020-08-24 00:00:00
abstract::In human pre-mRNA splicing, infrequent errors occur resulting in erroneous splice products as shown in a genome-wide approach. One characteristic subgroup consists of products lacking one cassette exon. The noise in the splicing process, represented by those misspliced products, can be increased by cold shock treatmen...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes2030562
更新日期:2011-08-02 00:00:00
abstract::n/a. ...
journal_title:Genes
pub_type: 杂志文章,已发布勘误
doi:10.3390/genes8030091
更新日期:2017-03-03 00:00:00
abstract::MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full-length MDM4 protein, and a shorter splice va...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes8020082
更新日期:2017-02-20 00:00:00
abstract::In China, the production for duck meat is second only to that of chicken, and the demand for duck meat is also increasing. However, there is still unclear on the internal mechanism of regulating skeletal muscle growth and development in duck. This study aimed to identity candidate genes related to growth of duck skele...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11101228
更新日期:2020-10-20 00:00:00
abstract::Adverse environmental exposures in pregnancy can significantly alter the development of the fetus resulting in impaired child neurodevelopment. Such exposures can lead to epigenetic alterations like DNA methylation, which may be a marker of poor cognitive, motor and behavioral outcomes in the infant. Here we review st...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes7120117
更新日期:2016-12-03 00:00:00
abstract::DNA methyltransferases (DNMTs) play an essential role in DNA methylation and transcriptional regulation in the genome. DNMTs, along with other poorly studied elements, modulate the dynamic DNA methylation patterns of embryonic and adult cells. We summarize the current knowledge on the molecular mechanism of DNMTs' fun...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11111336
更新日期:2020-11-12 00:00:00
abstract::Cell size affects almost all biosynthetic processes by controlling the size of organelles and disrupting the nutrient uptake process. Yeast cells must reach a critical size to be able to enter a new cell cycle stage. Abnormal changes in cell size are often observed under pathological conditions such as cancer disease....
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11040430
更新日期:2020-04-16 00:00:00
abstract::White spot syndrome virus (WSSV), one of the major pathogens of Procambarus clarkii, has caused severe disruption to the aquaculture industry of P. clarkii in China. To reveal the gene regulatory mechanisms underlying WSSV infection, a comparative transcriptome analysis was performed among WSSV-infected susceptible in...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8110320
更新日期:2017-11-10 00:00:00
abstract::Keratin-associated proteins (KAPs) are structural components of wool and hair fibers. To date, eight high glycine/tyrosine KAP (HGT-KAP) families have been identified in humans, but only three have been identified in sheep. In this study, the putative ovine homolog of the human KAP22-1 gene (KRTAP22-1) was amplified u...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8010027
更新日期:2017-01-11 00:00:00
abstract::The MinION sequencer has made in situ sequencing feasible in remote locations. Following our initial demonstration of its high performance off planet with Earth-prepared samples, we developed and tested an end-to-end, sample-to-sequencer process that could be conducted entirely aboard the International Space Station (...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010076
更新日期:2020-01-09 00:00:00
abstract::The transition from a dormant to a germinating seed represents a crucial developmental switch in the life cycle of a plant. Subsequent transition from a germinating seed to an autotrophic organism also requires a robust and multi-layered control. Seed germination and seedling growth are multistep processes, involving ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes12010052
更新日期:2020-12-31 00:00:00
abstract::Microaneurysms (MAs) are the earliest detectable diabetic retinopathy (DR) lesions. Thus, the ability to automatically detect MAs is critical for the early diagnosis of DR. However, achieving the accurate and reliable detection of MAs remains a significant challenge due to the size and complexity of retinal fundus ima...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10100817
更新日期:2019-10-17 00:00:00
abstract::We analysed nine microsatellite markers for 626 individuals representing the geographic range of eight closely related endemic New Zealand species of Sophora. Structure analysis identified the optimal K value as seven, with samples identified as Sophorachathamica, Sophorafulvida, Sophoralongicarinata, and Sophoraprost...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9020111
更新日期:2018-02-20 00:00:00
abstract::Porcine epidemic diarrhea (PED) is a major gastrointestinal disease afflicting suckling pigs that causes huge industrial economic losses. In this study, we investigated microbiota from the colonic mucosa and content in healthy and PED piglets. High-throughput 16S rRNA gene sequencing was performed to identify inter-gr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010044
更新日期:2019-12-30 00:00:00
abstract::Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes. Shelterin has evolved distinct solutions to protect telomeres from different aspects of the DNA damage response. These solutions include formation of t-loops, which can seq...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10040318
更新日期:2019-04-24 00:00:00